Project Detail
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Office of Autism Research Coordination (OARC) logo

The role of MECP2 in Rett syndrome  

Rett syndrome has been considered a "Rosetta stone" for deciphering the complex genetics of autism because it is the only one of the five pervasive developmental disorders with a known genetic cause. This proposal seeks to understand how the product of the Rett gene, MeCP2, operates inside the nuclei of post-natal neurons to regulate important gene regulatory events in learning and memory.


Funder National Institutes of Health
Fiscal Year Funding $251,626.00
Project Number R01HD041462-06A2
Principal Investigator LaSalle, Janine
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects The role of MECP2 in Rett syndrome | $308,949.00 | 2009 | 5R01HD041462-07
The role of MECP2 in Rett syndrome (supplement) | $34,417.00 | 2009 | 3R01HD041462-07S1
The role of MECP2 in Rett syndrome - Supplement | $47,769.00 | 2008 | R01HD041462-06A2S1
The role of MeCP2 in Rett syndrome | $337,753.00 | 2010 | 5R01HD041462-08