Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Unraveling the genetic etiology of autism  

This research will pursue promising initial studies implicating a network of loci critical for the development and regulation of central serotonergic function. Researchers will determine the nature and extent of susceptibility associated with the serotonin (5-HT) transporter (SLC6A4) and integrin 33 (ITGB3) loci, which lie within a chromosome 17q11-21 region conferring significant male-biased genetic risk in autism. This project will substantially advance understanding of how genetic variation affects expression and function of proteins controlling development and interconnection of a vital neurotransmitter system that is implicated in the etiologies of autism and many other disorders.


Funder National Institutes of Health
Fiscal Year Funding $485,467.00
Project Number R01NS049261-03
Principal Investigator Sutcliffe, James
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution Vanderbilt University
State/Country Tennessee
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Unraveling the genetic etiology of autism | $491,266.00 | 2009 | 5R01NS049261-04
Unraveling the genetic etiology of autism | $500,900.00 | 2010 | 5R01NS049261-05