Project Detail
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Chromatin remodeling and neuronal differentiation  

This project is studying how chromatin remodeling regulates neuronal function and synaptic plasticity through changes in gene expression. The investigators use cultured human EC cells (stem-cell like cells) in this work. Because chromatin remodeling may regulate gene expression programs involved in neurodegenerative disorders, such as Alzheimers', and developmental disorders, such as autism, this work might have implications for these disorders. The investigators have found chromatin remodeling enzymes can bind to and regulate expression of genes thought to be important in autism. Mutant versions of one chromatin protein, MeCP2, are the cause of Retts' syndrome, an Autism/Pervasive Developmental Disorder subtype.


Funder National Institutes of Health
Fiscal Year Funding $183,506.00
Project Number Z01AG000377-01
Principal Investigator Pazin, Michael
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution National Institutes of Health
State/Country Maryland
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Web Link 2 No URL available.
Web Link 3 No URL available.
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