This project is studying how chromatin remodeling regulates neuronal function and synaptic plasticity through changes in gene expression. The investigators use cultured human EC cells (stem-cell like cells) in this work. Because chromatin remodeling may regulate gene expression programs involved in neurodegenerative disorders, such as Alzheimers', and developmental disorders, such as autism, this work might have implications for these disorders. The investigators have found chromatin remodeling enzymes can bind to and regulate expression of genes thought to be important in autism. Mutant versions of one chromatin protein, MeCP2, are the cause of Retts' syndrome, an Autism/Pervasive Developmental Disorder subtype.