Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Gene silencing in fragile X syndrome  

Fragile X syndrome arises when the number of CGG-repeats in the 5' UTR (untranslated) of the FMR1 gene exceeds 200. Such alleles become silenced. The mechanism of gene silencing is unknown. This research will try to understand the mechanism responsible.


Funder National Institutes of Health
Fiscal Year Funding $321,321.00
Project Number Z01DK057602-12
Principal Investigator Usdin, Karen
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution National Institutes of Health
State/Country Maryland
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Gene silencing in fragile X syndrome | $323,483.00 | 2010 | 1ZIADK057602-14
Gene silencing in fragile X syndrome | $312,908.00 | 2009 | 1ZIADK057602-13