Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Blood expression profiles in children with Down syndrome  

The objective of this study is to examine gene expression patterns in children with Down syndrome with and without autism. The patterns of genes that are expressed differently in the children with and without autism will identify candidate genes for susceptibility to autism with regression. These patterns are expected to identify candidate genes on chromosome 21 and candidate genes on other chromosomes that interact with genes on chromosome 21. These candidates can be further examined for contribution to autism with regression in children with autism with and withot Down syndrome.

2008

Funder National Institutes of Health
Fiscal Year Funding $7,803.00
Project Number M01RR008084-15
Principal Investigator Molloy, Cynthia
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3.9 Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect nested, case-control data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.
Federal or Private? Federal
Institution Cincinnati Children's Hospital Medical Center
State/Country Ohio
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Web Link 3 No URL available.
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