Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Distinct function of the neuroligin 3 postsynaptic adhesion complex  

The goal of this proposal is to elucidate the role of NLS in synaptogenesis at the cellular and biochemical level. Experiments will use a combination of cellular assays in dissociated hippocampal neurons, molecular biology approaches, and biochemical methods to probe protein-protein interactions between NLS isoforms, neurexins, and neurotransmitter receptors. The results obtained in the proposed experiments will yield a detailed functional characterization of NLS that will provide the basis for understanding cellular defects associated with autism-spectrum disorders.


Funder National Institutes of Health
Fiscal Year Funding $45,972.00
Project Number F30MH083473-02
Principal Investigator Budreck, Elaine
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Columbia University
State/Country New York
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Distinct function of the neuroligin 3 postsynaptic adhesion complex | $37,784.00 | 2009 | 5F30MH083473-03