Project Detail
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Office of Autism Research Coordination (OARC) logo

Analysis of FGF17 roles and regulation in mammalian forebrain development  

The proposed studies use mouse genetics to analyze the roles and regulation of Fgf17 in the RFSC. This work will provide novel insight as to the molecular mechanisms of Fgf17 function and regulation in forebrain development. It will also lay the foundation for future collaborative projects (beyond the scope of this proposal) that will determine which roles of Fgf17 underlie the cognitive and behavioral phenotypes of Fgf17null mice. Together, these analyses will help to identify developmental processes and regulatory factors that contribute to the etiologies of autism and related psychiatric disorders.


Funder National Institutes of Health
Fiscal Year Funding $51,886.00
Project Number F32MH081431-01A2
Principal Investigator Hoch, Renee
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of California, San Francisco
State/Country California
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Analysis of Fgf17 roles and regulation in mammalian forebrain development | $52,154.00 | 2010 | 5F32MH081431-02