Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular determinants of L-type calcium channel gating  

Dysregulation of L-type channel functional expression underlies a wide range of diseases including life-threatening atrial arrhythmias, autism, night blindness, and deafness. The long-term objective of this research is two fold: first, to increase fundamental molecular understanding of structure-function mechanisms underlying L-type channel functional expression; second, to bridge these basic insights to a new realization of the (patho)physiological roles and therapeutic potential of L-type channels.


Funder National Institutes of Health
Fiscal Year Funding $402,500.00
Project Number R01HL069911-07
Principal Investigator Colecraft, Henry
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Columbia University
State/Country New York
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Molecular determinants of L-type calcium channel gating | $402,500.00 | 2009 | 5R01HL069911-08