Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Steroid receptors and brain sex differences  

Researchers plan to investigate the functional role ligand-independent activation of estrogen receptors (ER) in developing brain. Recent data indicate that acute changes in dopamine transmission during the first few days of life can dramatically alter the developmental organization of social play behavior by activating ER in a ligand-independent manner. As social play behavior is dramatically disrupted in children with autism and Asperger's syndrome, and social play behavior in rodents has been used as a rodent model for the study of autism, it is possible that these data will further understanding of how sexually dimorphic social disorders occur during brain development.


Funder National Institutes of Health
Fiscal Year Funding $301,359.00
Project Number R01MH072956-03
Principal Investigator Auger, Anthony
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of Wisconsin - Madison
State/Country Wisconsin
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Steroid receptors and brain sex differences | $301,301.00 | 2009 | 5R01MH072956-04
Steroid receptors and brain sex differences | $301,240.00 | 2010 | 5R01MH072956-05