Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders  

Different mutations in the X-linked human Arx homeobox gene have been associated with a range of developmental disorders from cortical malformations to behavioral dysfunction linked to autism. The Arx knockout male mouse also exhibits defects in brain structure consistent with the most severe human disorders, indicating that ARX acts similarly in these two species. This study will take advantage of the unique experimental tools available in the mouse and C. elegans model systems to further investigate ARX functions.


Funder National Institutes of Health
Fiscal Year Funding $211,950.00
Project Number R21MH077741-02
Principal Investigator Sengupta, Piali
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Brandeis University
State/Country Massachusetts
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