Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

A mouse knock-in model for Engrailed 2 autism susceptibility  

Although there is strong evidence for a genetic contribution to ASD, the isolation of specific causative genetic defects has been difficult. The researchers' previous work has focused on the homeobox transcription factor ENGRAILED 2 (EN2). They have demonstrated consistent association for two intronic EN2 SNPs, rs1861972 and rs1861973, in three separate datasets. These findings determined that EN2 is a likely ASD susceptibility gene.The goal of this study is to generate a mouse model for the EN2 risk allele by using recombinase- mediated genomic replacement (RMGR).


Funder National Institutes of Health
Fiscal Year Funding $152,764.00
Project Number R21MH083509-01
Principal Investigator Millonig, James
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
State/Country New Jersey
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects A mouse knock-in model for ENGRAILED 2 autism susceptibility | $227,135.00 | 2010 | 4R33MH083509-03
A mouse knock-in model for ENGRAILED 2 autism susceptibility | $152,667.00 | 2009 | 5R21MH083509-02