Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Regulation of gene expression in the brain  

Vasopressin (Avp) and oxytocin (Oxt) are neurohormones that are best known for their peripheral actions in regulating salt and water balance, blood pressure, lactation and parturition. However, numerous pharmacological studies have implicated these hormones in various behaviors as well, including aggressive, affiliative, and maternal. Researchers have made gene knockouts (KO) for the mouse Oxt, and Avp 1a and Avp 1b receptors (Oxt, Avpr1a and Avpr1b, respectively) to investigate their specific roles in mediating behavior.


Funder National Institutes of Health
Fiscal Year Funding $1,548,920.00
Project Number Z01MH002498-19
Principal Investigator Young, Walter
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution National Institutes of Health
State/Country Maryland
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Regulation of gene expression in the brain | $2,086,763.00 | 2010 | 1ZIAMH002498-21
Regulation of gene expression in the brain | $2,125,882.00 | 2009 | 1ZIAMH002498-20