Project Detail
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Slick and slack heteromers in neuronal excitability  

KNa channels are activated by intracellular sodium and show only weak voltage dependence. The two genes which encode these channels, Slack and Slick, show overlapping mRNA and protein expression in certain brain regions, most notably in the auditory and olfactory systems. Slack and Slick channels differ significantly in their activation kinetics and their sensitivity to intracellular chloride, ATP and PKC. Furthering understanding of normal sensory encoding could have far reaching implications towards understanding of autism and other overlapping conditions such as fragile X syndrome, Rett syndrome and Tuberous sclerosis complex. In addition, advancing the knowledge of this unique class of channels will in all likelihood lead to therapeutic interventions due to their putative protective roles in hypoxia and cerebral ischemia. Moreover, their pharmacological activation would make them a target for control of epileptic seizure activity.


Funder National Institutes of Health
Fiscal Year Funding $51,278.00
Project Number F32DC008449-01A1
Principal Investigator Kronengold, Jack
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Slick and Slack heteromers in neuronal excitability | $9,298.00 | 2010 | 5F32DC008449-03
Slick and slack heteromers in neuronal excitability | $53,354.00 | 2009 | 5F32DC008449-02