Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Multimodal neuroimaging of white matter in autism  

Large brains are common in autism, but their underlying tissue microstructure and their impact on the autistic phenotype are not understood. This proposal is based on the model that increased white matter volume is related to impaired connectivity and to underlying core processing abnormalities in autism. To test this model researchers will pursue their prior findings that white matter enlargement drives large brains and is localized to the later-rhyelinating radiate zone (the white matter closest to the cerebral cortex). They will use multispectral magnetic resonance imaging (MRI) to gain systematic information about the tissue microstructure and patterns of structural connectivity of enlarged white matter in autism and will relate these findings to cognitive and behavioral phenotype and to genome data.


Funder National Institutes of Health
Fiscal Year Funding $698,987.00
Project Number R01NS048455-03
Principal Investigator Herbert, Martha
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Massachusetts General Hospital
State/Country Massachusetts
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Multimodal neuroimaging of white matter in autism | $472,805.00 | 2009 | 5R01NS048455-04