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Engrailed and the control of synaptic circuitry in Drosophila  

Engrailed is a transcriptional regulator that has recently been linked to fate determination and survival of midbrain dopaminergic neurons with En knockout mice showing Parkinson-like symptoms and has also been linked to autism spectrum disorder. The objective of this research is to use simple model systems that have identifiable neurons to investigate the role En plays in regulating neuronal connectivity. Specifically, it will examine how Engrailed controls synaptic target recognition and determine the downstream effector genes that it regulates.


Funder National Institutes of Health
Fiscal Year Funding $112,500.00
Project Number SC2NS065384-01
Principal Investigator Blagburn, Jonathan
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Puerto Rico Medical Sciences
State/Country Puerto Rico
Web Link 1 No URL available.
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Engrailed and the control of synaptic circuitry in Drosophila | $112,500.00 | 2009 | 5SC2NS065384-02
Engrailed and the control of synaptic circuitry in drosophila | $112,500.00 | 2010 | 5SC2NS065384-03