Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Young development of a novel PET ligand for detecting oxytocin receptors in brain Young, Larry Q2.Other Emory University
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Q2.S.D Children's Hospital Boston
Ube3a requirements for structural plasticity of synapses McCoy, Portia Q2.Other Univ of North Carolina
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi Q2.S.D University of California, Los Angeles
Translation regulation in hippocampal LTP and LTD Klann, Eric Q2.S.D New York University
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan Q2.S.D University of California, San Diego
The role of MeCP2 in Rett syndrome LaSalle, Janine Q2.S.D University of California, Davis
The role of intracellular metabotropic glutamate receptor 5 at the synapse Hogan, Carolyn Q2.S.D Washington University in St. Louis
The role of FOX-1 in neurodevelopment and autistic spectrum disorder Fogel, Brent Q2.Other University of California, Los Angeles
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Q2.Other Johns Hopkins University School of Medicine
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D University of Massachusetts Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D J. David Gladstone Institutes
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.S.D University of Washington
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.Other Children's Memorial Hospital, Chicago
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Q2.S.D Children's Memorial Hospital, Chicago
The effects of Npas4 and Sema4D on inhibitory synapse formation Greenberg, Michael Q2.Other Children's Hospital Boston
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles Q2.S.D University of Illinois at Urbana Champaign
Synaptic analysis of neuroligin1 function Fuccillo, Marc Q2.Other Stanford University
Study of fragile X mental retardation protein in synaptic function and plasticity Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn Q2.Other National Institutes of Health
Steroid receptors and brain sex differences Auger, Anthony Q2.S.B University of Wisconsin - Madison
Serotonin signal transduction in two groups of autistic patients Rasenick, Mark Q2.Other University of Illinois at Chicago
Self-injurious behavior: An animal model of an autism endophenotype Devine, Darragh Q2.Other University of Florida
Roles of Wnt signaling/scaffolding molecules in autism Okerlund, Nathan Q2.Other University of California, San Francisco
Role of Pam in synaptic morphology and function Ramesh, Vijaya Q2.Other Massachusetts General Hospital