Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Immune/Metabolic Pathways$5,385,744.28
Fiscal Year: 2010

Download 2010 Immune/Metabolic Pathways projects (EXCEL)
These projects focus on understanding the biological mechanisms of metabolism and the immune system that may be altered in autism, typically in cells and animal models. This largely includes studies on inflammation and inflammatory molecules (i.e., cytokines), as well as on the role of mitochondria, energy metabolism, and oxidative stress. Also included in this group are projects seeking to identify specific immune and metabolic triggers in early prenatal and post-natal life, such as maternal infection, maternal auto-antibodies, and toxic exposures.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Primate models of autism Bauman, Melissa Q2.S.A University of California, Davis
EFRI- BSBA: Novel microsystems for manipulation and analysis of immune cells Revzin, Alexander Q2.S.A University of California, Davis
Early biologic markers for autism Croen, Lisa Q2.S.A Kaiser Permanente Division of Research
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn Q2.S.A The Fox Chase Cancer Center
Influence of the maternal immune response on the development of autism Ponzio, Nicholas Q2.S.A University of Medicine & Dentistry of New Jersey
The pathogenesis of autism: Maternal antibody exposure in the fetal brain Diamond, Betty Q2.S.A The Feinstein Institute for Medical Research
Prostaglandins and cerebellum development McCarthy, Margaret Q2.S.A University of Maryland, Baltimore
A primate model of gut, immune, and CNS response to childhood vaccines Sackett, Gene Q2.S.A University of Washington
Environmentally induced oxidative stress and altered local brain thyroid horomone metabolism: relevance to autism? Sajdel-Sulkowski, Elizabeth Q2.S.A Harvard Medical School; Brigham and Women's Hospital
The effect of mercury and neuropeptide triggers on human mast cell release of neurotoxic molecules Theohardies, Theoharis Q2.S.A Tufts University
Does mercury and neurotension induce mitochondrial DNA release from human mast cells and contribute to auto-immunity in ASD? Theohardies, Theoharis Q2.S.A Tufts University
Systematic characterization of the immune response to gluten and casein in autism spectrum disorders Alaedini, Armin Q2.S.A Weill Cornell Medical College
Mechanisms of mitochondrial dysfunction in autism Shoffner, John Q2.S.A Georgia State University
Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders Antonucci, Nicola Q2.S.A University of Naples
Project 2: Immunological susceptibility of autism Van de Water, Judy Q2.S.A University of California, Davis
Primate models of autism Bauman, Melissa; Amaral, David Q2.S.A University of California, Davis
A mitochondrial etiology of autism Wallace, Douglas Q2.S.A Children's Hospital of Philadelphia
An ex-vivo placental perfusion system to study materno-fetal biology Bonnin, Alexandre Q2.S.A University of Southern California
CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles Cory-Slechta, Deborah Q2.S.A University of Rochester
Study of anti-neuronal autoantibodies in behavioral and movement disorders Cunningham, Madeleine Q2.S.A University of Oklahoma Health Sciences Center
A role for immune molecules in cortical connectivity: Potential implications for autism Elmer, Bradford Q2.S.A University of California, Davis
Is autism a mitochondrial disease? Giulivi, Cecilia Q2.S.A University of California, Davis
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Hepel, Maria Q2.S.A State University of New York at Potsdam
How does IL-6 mediate the development of autism-related behaviors? Hsiao, Elaine Q2.S.A California Institute of Technology
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development James, Sandra Q2.S.A Arkansas Children's Hospital Research Institute