Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
Investigation of sex differences associated with autism candidate gene, CYFIP1 Werling, Donna Q2.S.B University of California, Los Angeles
Steroid receptors and brain sex differences Auger, Anthony Q2.S.B University of Wisconsin - Madison
Quantitative proteomic approach towards understanding and treating autism Jin, Peng Q2.S.D Emory University
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.S.D University of Washington
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Q2.S.D Stanford University
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Q2.S.D Washington University in St. Louis
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Q2.S.D Stanford University
Angelman syndrome (AS) Percy, Alan Q2.S.D University of Alabama at Birmingham
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas Q2.S.D University of Alabama at Birmingham
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Q2.S.D Dana-Farber Cancer Institute
Regulation of synapse elimination by FMRP Wilkerson, Julia Q2.S.D University of Texas Southwestern Medical Center
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Q2.S.D Johns Hopkins University
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Q2.S.D Children's Hospital Boston
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Q2.S.D Massachusetts Institute of Technology
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Q2.S.D Columbia University
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Q2.S.D Columbia University
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi Q2.S.D University of California, Los Angeles
Presynaptic fragile X proteins Akins, Michael Q2.S.D Brown University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Q2.S.D Baylor College of Medicine
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Q2.S.D Stanford University
Gene silencing in fragile X syndrome Usdin, Karen Q2.S.D National Institutes of Health
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan Q2.S.D University of California, San Diego
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence Q2.S.D University of Tennessee Health Science Center