Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Engrailed and the control of synaptic circuitry in drosophila Blagburn, Jonathan Q2.Other University of Puerto Rico Medical Sciences Campus
Autism-specific mutation in DACT1: Impact on brain development in a mouse model Cheyette, Benjamin Q2.Other University of California, San Francisco
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity Comoletti, Davide Q2.Other University of California, San Diego
Cellular characterization of Caspr2 Comoletti, Davide Q2.Other University of California, San Diego
Self-injurious behavior: An animal model of an autism endophenotype Devine, Darragh Q2.Other University of Florida
Molecular mechanisms regulating synaptic strength DiAntonio, Aaron Q2.Other Washington University
Homeostatic regulation of presynaptic function by dendritic mTORC1 Henry, Fredrick Q2.Other University of Michigan
Analysis of Fgf17 roles and regulation in mammalian forebrain development Hoch, Renee Q2.Other University of California, San Francisco
Retrograde synaptic signaling by Neurexin and Neuroligin in C. elegans Kaplan, Joshua Q2.Other Massachusetts General Hospital
Developing novel automated apparatus for studying battery of social behaviors in mutant mouse models for autism Kimchi, Tali Q2.Other Weizmann Institute of Science
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.Other Children's Memorial Hospital, Chicago
Role of GluK6 in cerebella circuitry development Kubera, Cathryn Q2.Other Yale University
Ube3a requirements for structural plasticity of synapses McCoy, Portia Q2.Other Univ of North Carolina
Cell adhesion molecules in CNS development Mueller, Ulrich Q2.Other The Scripps Research Institute
Elucidating the function of class 4 semaphorins in GABAergic synapse formation Paradis, Suzanne Q2.Other Brandeis University
Glutamate receptor desensitization and its modulation Partin, Kathryn Q2.Other Colorado State University
Met signaling in neural development and circuitry formation Qiu, Shenfeng Q2.Other University of Southern California
Serotonin signal transduction in two groups of autistic patients Rasenick, Mark Q2.Other University of Illinois at Chicago
Glial control of neuronal receptive ending morphology Shaham, Shai Q2.Other The Rockefeller University
Role of neuronal migration genes in synaptogenesis and plasticity Sudarov, Anamaria Q2.Other Weill Cornell Medical College
A systematic test of the relation of ASD heterogeneity to synaptic function Sudhof, Thomas; Malenka, Robert Q2.Other Stanford University
Kinetics of drug macromolecule complex formation Taylor, Palmer Q2.Other University of California, San Diego
Imaging PTEN-induced changes in adult cortical structure and function in vivo Trachtenberg, Joshua Q2.Other University of California, Los Angeles
Brain lipid rafts in cholesterol biosynthesis disorders Yu, Hongwei Q2.Other Medical College of Wisconsin
Autism and the insula: Genomic and neural circuits Allman, John Q2.Other California Institute of Technology