Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Novel, subtype selective potentiators of nicotinic acetycholine receptors Schulte, Marvin Q4.Other University of Alaska Fairbanks
Design & synthesis of novel CNS-active oxytocin and vasopressin receptor ligands Roberts, Edward Q4.Other The Scripps Research Institute
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Q4.S.B Beth Israel Deaconess Medical Center
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Q4.S.B Massachusetts Institute of Technology
Neurobiology of mouse models for human chr 16p11.2 microdeletion and fragile X Bear, Mark Q4.S.B Massachusetts Institute of Technology
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Q4.S.B Vanderbilt University
The genetic control of social behavior in the mouse Blanchard, Robert Q4.S.B University of Hawai'i at Manoa
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward Q4.S.B University of Pennsylvania
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Q4.S.B Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Q4.S.B Mount Sinai School of Medicine
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie Q4.S.B New York University
Animal models of neuropsychiatric disorders Crawley, Jacqueline Q4.S.B National Institutes of Health
Investigation of the role of MET kinase in autism Dawson, Ted Q4.S.B Johns Hopkins University School of Medicine
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Q4.S.B Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Q4.S.B Stanford University
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph Q4.S.B The Rockefeller University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Q4.S.B Duke University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Q4.S.B Stanford University
Investigating the effects of chromosome 22q11.2 deletions Karayiorgou, Maria Q4.S.B Columbia University
Animal model of speech sound processing in autism Kilgard, Michael Q4.S.B University of Texas at Dallas
Shank3 mutant characterization in vivo Kouser, Mehreen Q4.S.B University of Texas Southwestern Medical Center
Insight into MeCP2 function raises therapeutic possibilities for Rett syndrome Lomvardas, Stavros Q4.S.B University of California, San Francisco
Evaluation of altered fatty acid metabolism via gas chromatography/mass spectroscopy and time-of-flight secondary ion mass spectroscopy imaging in the propionic acid rat model of autism spectrum disorders MacFabe, Derrick Q4.S.B University of Western Ontario
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Q4.S.B Stanford University
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Pedersen, Cort Q4.S.B University of North Carolina at Chapel Hill