Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Q2.Other Albert Einstein College of Medicine of Yeshiva University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Q2.S.D Baylor College of Medicine
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Q2.S.D Baylor College of Medicine
Elucidating the function of class 4 semaphorins in GABAergic synapse formation Paradis, Suzanne Q2.Other Brandeis University
Presynaptic fragile X proteins Akins, Michael Q2.S.D Brown University
Autism and the insula: Genomic and neural circuits Allman, John Q2.Other California Institute of Technology
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Q2.S.D Children's Hospital Boston
The effects of Npas4 and Sema4D on inhibitory synapse formation Greenberg, Michael Q2.Other Children's Hospital Boston
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Q2.S.D Children's Memorial Hospital, Chicago
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.Other Children's Memorial Hospital, Chicago
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Q2.S.D Cold Spring Harbor Laboratory
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution Zador, Anthony Q2.Other Cold Spring Harbor Laboratory
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Q2.Other Cold Spring Harbor Laboratory
Glutamate receptor desensitization and its modulation Partin, Kathryn Q2.Other Colorado State University
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Q2.S.D Columbia University
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Q2.S.D Columbia University
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Q2.S.D Dana-Farber Cancer Institute
BDNF secretion and neural precursor migration Zhao, Xuesong Q2.Other Dana-Farber Cancer Institute
Imaging signal transduction in single dendritic spines Yasuda, Ryohei Q2.Other Duke University
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Q2.Other Duke University
Quantitative proteomic approach towards understanding and treating autism Jin, Peng Q2.S.D Emory University