Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Role of GluK6 in cerebella circuitry development Kubera, Cathryn Q2.Other Yale University
Morphogenesis and function of the cerebral cortex Vaccarino, Flora Q2.Other Yale University
Identification of candidate genes at the synapse in autism spectrum disorders Gupta, Abha Q2.Other Yale University
Allelic choice in Rett syndrome Donohoe, Mary Q2.S.D Winifred Masterson Burke Medical Research Institute
Developing novel automated apparatus for studying battery of social behaviors in mutant mouse models for autism Kimchi, Tali Q2.Other Weizmann Institute of Science
Role of neuronal migration genes in synaptogenesis and plasticity Sudarov, Anamaria Q2.Other Weill Cornell Medical College
The role of intracellular metabotropic glutamate receptor 5 at the synapse Hogan, Carolyn Q2.S.D Washington University in St. Louis
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Q2.S.D Washington University in St. Louis
Molecular mechanisms regulating synaptic strength DiAntonio, Aaron Q2.Other Washington University
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Q2.S.D Virginia Commonwealth University
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Q2.S.D Vanderbilt University
Ube3a requirements for structural plasticity of synapses McCoy, Portia Q2.Other Univ of North Carolina
Steroid receptors and brain sex differences Auger, Anthony Q2.S.B University of Wisconsin - Madison
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku Q2.S.D University of Washington
Regulation of synapse elimination by FMRP Wilkerson, Julia Q2.S.D University of Texas Southwestern Medical Center
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay Q2.S.D University of Texas Southwestern Medical Center
Study of fragile X mental retardation protein in synaptic function and plasticity Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Coordinated control of synapse development by autism-linked genes Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis Q2.S.D University of Texas Southwestern Medical Center
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence Q2.S.D University of Tennessee Health Science Center
Met signaling in neural development and circuitry formation Qiu, Shenfeng Q2.Other University of Southern California
Function and structure adaptations in forebrain development Levitt, Pat Q2.Other University of Southern California
Engrailed and the control of synaptic circuitry in drosophila Blagburn, Jonathan Q2.Other University of Puerto Rico Medical Sciences Campus
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory Q2.S.D University of Pennsylvania