Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Model Systems/Therapeutic Targets$24,115,793.04
Fiscal Year: 2010

Download 2010 Model Systems/Therapeutic Targets projects (EXCEL)
Animal models mimicking behaviors of ASD and those that are being used to develop or test new drug treatments, as well as cell lines used to discover new drug targets or to screen potential drug candidates, are included in this subcategory.
Graph: The subcategories for Question 4 illustrate the many approaches to treatments and interventions supported by autism research funders. The largest amount of funding supported projects to develop Model systems and therapeutic targets (35%), followed by research on Behavioral interventions (29%). Medical/Pharmacologic interventions received 16% of funding, classroom-based interventions (Educational) received 10% of funding, and Technology-based interventions and supports received 7% of funding. The subcategories with the smallest amounts of funding included Occupational, physical, and sensory-based (2%) and Complementary, dietary, and alternative (1%).
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Q4.S.B Beth Israel Deaconess Medical Center
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Ali Q4.S.B Johns Hopkins University
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Q4.S.B Massachusetts Institute of Technology
Neurobiology of mouse models for human chr 16p11.2 microdeletion and fragile X Bear, Mark Q4.S.B Massachusetts Institute of Technology
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Q4.S.B Vanderbilt University
The genetic control of social behavior in the mouse Blanchard, Robert Q4.S.B University of Hawai'i at Manoa
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward Q4.S.B University of Pennsylvania
Identifying genetic modifiers of rett syndrome in the mouse Buchovecky, Christine Q4.S.B Baylor College of Medicine
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Q4.S.B Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Q4.S.B Mount Sinai School of Medicine
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie Q4.S.B New York University
Animal models of neuropsychiatric disorders Crawley, Jacqueline Q4.S.B National Institutes of Health
Investigation of the role of MET kinase in autism Dawson, Ted Q4.S.B Johns Hopkins University School of Medicine
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Q4.S.B Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Q4.S.B Stanford University
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph Q4.S.B The Rockefeller University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Q4.S.B Duke University
Patient iPS cells with copy number variations to model neuropsychiatric disorders Ellis, James Q4.S.B The Hospital for Sick Children
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Q4.S.B Massachusetts Institute of Technology
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Q4.S.B Massachusetts Institute of Technology
Functional genomic dissection of language-related disorders Fisher, Simon Q4.S.B University of Oxford
Deriving neuroprogenitor cells from peripheral blood of individuals with autism Fujinami, Robert Q4.S.B University of Utah
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Q4.S.B Stanford University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Q4.S.B Columbia University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Q4.S.B Stanford University