Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Developing novel automated apparatus for studying battery of social behaviors in mutant mouse models for autism Kimchi, Tali Q2.Other Weizmann Institute of Science
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Development of novel diagnostics for fragile X syndrome Hosono, Seiyu Q2.S.D JS Genetics, Inc.
Elucidating the function of class 4 semaphorins in GABAergic synapse formation Paradis, Suzanne Q2.Other Brandeis University
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Q2.S.D Baylor College of Medicine
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua Q2.S.D George Washington University
Engrailed and the control of synaptic circuitry in drosophila Blagburn, Jonathan Q2.Other University of Puerto Rico Medical Sciences Campus
Engrailed genes and cerebellum morphology, spatial gene expression and circuitry Joyner, Alexandra Q2.Other Memorial Sloan-Kettering Cancer Center
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Q2.S.D Virginia Commonwealth University
Excessive cap-dependent translation as a molecular mechanism underlying ASD Klann, Eric Q2.Other New York University
Functional analysis of neurexin IV in Drosophila Zipursky, Larry Q2.Other University of California, Los Angeles
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory Q2.S.D University of Pennsylvania
Function and dysfunction of neuroligins in synaptic circuits Sudhof, Thomas Q2.Other Stanford University
Function and structure adaptations in forebrain development Levitt, Pat Q2.Other University of Southern California
Function of neurexins Sudhof, Thomas Q2.Other Stanford University
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Q2.S.D Emory University
GABA(A) receptor modulation via the beta subunit Jenkins, Andrew Q2.Other Emory University
GABAergic dysfunction in autism Fatemi, Seyyed Q2.Other University of Minnesota
Gene silencing in fragile X syndrome Usdin, Karen Q2.S.D National Institutes of Health
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Q2.S.D Vanderbilt University
Genetic studies of autism-related Drosophila neurexin and neuroligin Bhat, Manzoor Q2.Other The University of North Carolina at Chapel Hill
Glial control of neuronal receptive ending morphology Shaham, Shai Q2.Other The Rockefeller University
Glutamate receptor desensitization and its modulation Partin, Kathryn Q2.Other Colorado State University
High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution Zador, Anthony Q2.Other Cold Spring Harbor Laboratory
Homeostatic regulation of presynaptic function by dendritic mTORC1 Henry, Fredrick Q2.Other University of Michigan