Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Q2.S.D Emory University
Young development of a novel PET ligand for detecting oxytocin receptors in brain Young, Larry Q2.Other Emory University
GABA(A) receptor modulation via the beta subunit Jenkins, Andrew Q2.Other Emory University
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua Q2.S.D George Washington University
Activity-dependent phosphorylation of MeCP2 Ebert, Daniel Q2.S.D Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Q2.S.D Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Q2.S.D Harvard Medical School
Perturbed activity-dependent plasticity mechanisms in autism Sabatini, Bernardo Q2.Other Harvard Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D J. David Gladstone Institutes
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Q2.S.D Johns Hopkins University
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Q2.Other Johns Hopkins University School of Medicine
Development of novel diagnostics for fragile X syndrome Hosono, Seiyu Q2.S.D JS Genetics, Inc.
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Q2.S.D Massachusetts General Hospital
Retrograde synaptic signaling by Neurexin and Neuroligin in C. elegans Kaplan, Joshua Q2.Other Massachusetts General Hospital
Role of Pam in synaptic morphology and function Ramesh, Vijaya Q2.Other Massachusetts General Hospital
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Q2.S.D Massachusetts Institute of Technology
Imaging synaptic neurexin-neuroligin complexes by proximity biotinylation: Applications to the molecular pathogenesis of autism Thyagarajan, Amar Q2.Other Massachusetts Institute of Technology
Regulation of synaptogenesis by cyclin-dependent kinase 5 Tsai, Li-Huei Q2.Other Massachusetts Institute of Technology
Brain lipid rafts in cholesterol biosynthesis disorders Yu, Hongwei Q2.Other Medical College of Wisconsin
Engrailed genes and cerebellum morphology, spatial gene expression and circuitry Joyner, Alexandra Q2.Other Memorial Sloan-Kettering Cancer Center
Gene silencing in fragile X syndrome Usdin, Karen Q2.S.D National Institutes of Health
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn Q2.Other National Institutes of Health
Translation regulation in hippocampal LTP and LTD Klann, Eric Q2.S.D New York University
Excessive cap-dependent translation as a molecular mechanism underlying ASD Klann, Eric Q2.Other New York University
Role of neuroligin in synapse stability Rand, James Q2.Other Oklahoma Medical Research Foundation