Subcategory Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Subgroups/Biosignatures$12,401,288.07
Fiscal Year: 2010
  

Download 2010 Subgroups/Biosignatures projects (EXCEL)
Because there is so much heterogeneity among individuals with autism, research to understand how certain subgroups of individuals that share certain behavioral or biological characteristics could help understand some of the underlying biology in ASD. This can be done by searching for certain biological factors ("signatures"), such as hormone levels or structural abnormalities in the brain, that define a particular subgroup. Many of these projects try to make the connection between certain genes with a known or suspected link to autism and the observable characteristic, or phenotype, that they cause.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G University of North Carolina at Chapel Hill
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Q2.S.G Northwestern University
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Manoach, Dara Q2.S.G Massachusetts General Hospital
An investigation of the overlap of autism and fragile X syndrome Martin, Gary Q2.S.G University of North Carolina at Chapel Hill
The genetic link between autism and structural cerebellar malformations Millen, Kathleen Q2.S.G University of Chicago
Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD Monk, Christopher Q2.S.G University of Michigan
Linking local activity and functional connectivity in autism Mueller, Ralph-Axel Q2.Other San Diego State University
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Q2.S.G Emory University
Longitudinal neurogenetics of atypical social brain development in autism Pelphrey, Kevin Q2.S.G Yale University
Identifying brain-based biomarkers for ASD & their biological subtypes Peterson, Bradley Q2.Other New York State Psychiatric Institute
Neural circuitry of social cognition in the broad autism phenotype Piven, Joseph Q2.S.G University of North Carolina at Chapel Hill
Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates Radoeva, Petya Q2.S.G State University of New York Upstate Medical University
Gamma band dysfunction as a local neuronal connectivity endophenotype in autism Rojas, Donald Q2.Other University of Colorado Denver
Creating a specimen bank of neurotypical individuals Russo, A.J. Q2.Other Health Research Institute
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Santangelo, Susan Q2.S.G Massachusetts General Hospital
Relating copy number variants to head and brain size in neuropsychiatric disorders Sebat, Jonathan Q2.S.G University of California, San Diego
Simons Variation in Individuals Project (Simons VIP) Core Leader Gift Sherr, Elliott Q2.S.G University of California, San Francisco
Autistic endophenotypes and their associations to oxytocin and cholesterol Silverman, Jeremy Q2.Other Mount Sinai School of Medicine
Neurogenic growth factors in autism Vaccarino, Flora Q2.S.G Yale University
Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral endophenotypes Webb, Sara Q2.S.G University of Washington
ACE Center: Genetic contributions to endophenotypes of autism Wijsman, Ellen Q2.S.G University of Washington
MEG investigation of phonological processing in autism Wilson, Lisa Q2.Other University of Colorado Denver
Functional imaging of flexibility in autism: Informed by SLC6A4 Yerys, Benjamin Q2.S.G Children's Research Institute