Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Q2.S.D Johns Hopkins University
Perturbed activity-dependent plasticity mechanisms in autism Sabatini, Bernardo Q2.Other Harvard Medical School
Presynaptic fragile X proteins Akins, Michael Q2.S.D Brown University
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Q2.S.D Stanford University
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence Q2.S.D University of Tennessee Health Science Center
Quantitative proteomic approach towards understanding and treating autism Jin, Peng Q2.S.D Emory University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony Q2.S.D The George Washington University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony Q2.S.D University of North Carolina at Chapel Hill
Regulation of activity-dependent ProSAP2 synaptic dynamics Rowan, Magali Q2.Other Stanford University
Regulation of synapse elimination by FMRP Wilkerson, Julia Q2.S.D University of Texas Southwestern Medical Center
Regulation of synaptogenesis by cyclin-dependent kinase 5 Tsai, Li-Huei Q2.Other Massachusetts Institute of Technology
Retrograde synaptic signaling by Neurexin and Neuroligin in C. elegans Kaplan, Joshua Q2.Other Massachusetts General Hospital
Role of autism-susceptibility gene, CNTNAP2, in neural circuitry for vocal communication White, Stephanie Q2.Other University of California, Los Angeles
Role of GluK6 in cerebella circuitry development Kubera, Cathryn Q2.Other Yale University
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Q2.S.D Washington University in St. Louis
Role of micro-RNAs in ASD affected circuit formation and function Ullian, Erik Q2.Other University of California, San Francisco
Role of neuroligin in synapse stability Rand, James Q2.Other Oklahoma Medical Research Foundation
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Q2.Other Albert Einstein College of Medicine of Yeshiva University
Role of neuronal migration genes in synaptogenesis and plasticity Sudarov, Anamaria Q2.Other Weill Cornell Medical College
Role of Pam in synaptic morphology and function Ramesh, Vijaya Q2.Other Massachusetts General Hospital
Roles of Wnt signaling/scaffolding molecules in autism Okerlund, Nathan Q2.Other University of California, San Francisco
Self-injurious behavior: An animal model of an autism endophenotype Devine, Darragh Q2.Other University of Florida
Serotonin signal transduction in two groups of autistic patients Rasenick, Mark Q2.Other University of Illinois at Chicago
Steroid receptors and brain sex differences Auger, Anthony Q2.S.B University of Wisconsin - Madison
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn Q2.Other National Institutes of Health