Subcategory Detail
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Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly Q2.S.D University of Texas Southwestern Medical Center
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Q2.S.D Cold Spring Harbor Laboratory
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Q2.Other Cold Spring Harbor Laboratory
Development of novel diagnostics for fragile X syndrome Hosono, Seiyu Q2.S.D JS Genetics, Inc.
The role of intracellular metabotropic glutamate receptor 5 at the synapse Hogan, Carolyn Q2.S.D Washington University in St. Louis
Analysis of Fgf17 roles and regulation in mammalian forebrain development Hoch, Renee Q2.Other University of California, San Francisco
Homeostatic regulation of presynaptic function by dendritic mTORC1 Henry, Fredrick Q2.Other University of Michigan
Defining cells and circuits affected in autism spectrum disorders Heintz, Nathaniel Q2.Other The Rockefeller University
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Q2.S.D Emory University
Identification of candidate genes at the synapse in autism spectrum disorders Gupta, Abha Q2.Other Yale University
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Q2.S.D Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Q2.S.D Harvard Medical School
The effects of Npas4 and Sema4D on inhibitory synapse formation Greenberg, Michael Q2.Other Children's Hospital Boston
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay Q2.S.D University of Texas Southwestern Medical Center
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D University of Massachusetts Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao Q2.S.D J. David Gladstone Institutes
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine Q2.S.D University of California, Irvine
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Q2.Other Johns Hopkins University School of Medicine
Synaptic analysis of neuroligin1 function Fuccillo, Marc Q2.Other Stanford University
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Q2.Other Duke University
The role of FOX-1 in neurodevelopment and autistic spectrum disorder Fogel, Brent Q2.Other University of California, Los Angeles
GABAergic dysfunction in autism Fatemi, Seyyed Q2.Other University of Minnesota
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Q2.Other Albert Einstein College of Medicine of Yeshiva University
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Q2.S.D Virginia Commonwealth University