Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Activity-dependent phosphorylation of MeCP2 Ebert, Daniel Q2.S.D Harvard Medical School
Allelic choice in Rett syndrome Donohoe, Mary Q2.S.D Winifred Masterson Burke Medical Research Institute
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Q2.S.D Children's Memorial Hospital, Chicago
Molecular mechanisms regulating synaptic strength DiAntonio, Aaron Q2.Other Washington University
Self-injurious behavior: An animal model of an autism endophenotype Devine, Darragh Q2.Other University of Florida
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles Q2.S.D University of Illinois at Urbana Champaign
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua Q2.S.D George Washington University
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity Comoletti, Davide Q2.Other University of California, San Diego
Cellular characterization of Caspr2 Comoletti, Davide Q2.Other University of California, San Diego
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta Q2.S.D University of Delaware
Autism-specific mutation in DACT1: Impact on brain development in a mouse model Cheyette, Benjamin Q2.Other University of California, San Francisco
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory Q2.S.D University of Pennsylvania
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Q2.S.D Vanderbilt University
Engrailed and the control of synaptic circuitry in drosophila Blagburn, Jonathan Q2.Other University of Puerto Rico Medical Sciences Campus
Genetic studies of autism-related Drosophila neurexin and neuroligin Bhat, Manzoor Q2.Other The University of North Carolina at Chapel Hill
Steroid receptors and brain sex differences Auger, Anthony Q2.S.B University of Wisconsin - Madison
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Q2.S.D Baylor College of Medicine
Autism and the insula: Genomic and neural circuits Allman, John Q2.Other California Institute of Technology
Presynaptic fragile X proteins Akins, Michael Q2.S.D Brown University