Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010
  

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Q2.Other Albert Einstein College of Medicine of Yeshiva University
GABAergic dysfunction in autism Fatemi, Seyyed Q2.Other University of Minnesota
The role of FOX-1 in neurodevelopment and autistic spectrum disorder Fogel, Brent Q2.Other University of California, Los Angeles
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Q2.Other Duke University
Synaptic analysis of neuroligin1 function Fuccillo, Marc Q2.Other Stanford University
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Q2.Other Johns Hopkins University School of Medicine
The effects of Npas4 and Sema4D on inhibitory synapse formation Greenberg, Michael Q2.Other Children's Hospital Boston
Defining cells and circuits affected in autism spectrum disorders Heintz, Nathaniel Q2.Other The Rockefeller University
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Q2.Other Cold Spring Harbor Laboratory
A systems biology approach to unravel the underlying functional modules of ASD Iakoucheva, Lilia Q2.Other University of California, San Diego
GABA(A) receptor modulation via the beta subunit Jenkins, Andrew Q2.Other Emory University
Engrailed genes and cerebellum morphology, spatial gene expression and circuitry Joyner, Alexandra Q2.Other Memorial Sloan-Kettering Cancer Center
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Q2.Other Columbia University
Excessive cap-dependent translation as a molecular mechanism underlying ASD Klann, Eric Q2.Other New York University
Function and structure adaptations in forebrain development Levitt, Pat Q2.Other University of Southern California
Roles of Wnt signaling/scaffolding molecules in autism Okerlund, Nathan Q2.Other University of California, San Francisco
Role of Pam in synaptic morphology and function Ramesh, Vijaya Q2.Other Massachusetts General Hospital
Autism-specific mutation in DACT1: Impact on brain development in a mouse model Cheyette, Benjamin Q2.Other University of California, San Francisco