Subcategory Detail
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Office of Autism Research Coordination (OARC) logo

Molecular Pathways$28,759,657.25
Fiscal Year: 2010

Download 2010 Molecular Pathways projects (EXCEL)
This subcategory includes studies on specific molecules and proteins (other than the immune and metabolic systems) that may be involved in the development of ASD and related genetic disorders (e.g., fragile X syndrome and Rett syndrome). Many of these projects use animal and cellular models to explore the biological effects of specific candidate genes and to identify common molecular pathways, including alterations in synaptic functioning and intracellular signaling cascades.
Graph: Question 2 encompassed a broad range of biological research, resulting in the need to create a larger number of subcategories to adequately describe the breadth of research than was required for other Strategic Plan Questions. The subcategory with the largest portion of funding was Molecular pathways (32%), followed by Neural systems and Subgroups/Biosignatures, which each received less than half the funding of Molecular pathways (15% and 14%, respectively). Projects related to Developmental trajectory were supported by 11% of 2010 ASD research funding, and research on Sensory and motor function received 7%. Studies on Immune/Metabolic pathways (6%), Co-occurring conditions (5%), Cognitive studies (5%), and Computational science (4%) round out the types of research in Question 2.
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Strategic Plan Objective Institution
Regulation of synaptogenesis by cyclin-dependent kinase 5 Tsai, Li-Huei Q2.Other Massachusetts Institute of Technology
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Q2.S.D Stanford University
Role of micro-RNAs in ASD affected circuit formation and function Ullian, Erik Q2.Other University of California, San Francisco
Gene silencing in fragile X syndrome Usdin, Karen Q2.S.D National Institutes of Health
Morphogenesis and function of the cerebral cortex Vaccarino, Flora Q2.Other Yale University
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
A sex-specific dissection of autism genetics Weiss, Lauren Q2.S.B University of California, San Francisco
Investigation of sex differences associated with autism candidate gene, CYFIP1 Werling, Donna Q2.S.B University of California, Los Angeles
Role of autism-susceptibility gene, CNTNAP2, in neural circuitry for vocal communication White, Stephanie Q2.Other University of California, Los Angeles
Regulation of synapse elimination by FMRP Wilkerson, Julia Q2.S.D University of Texas Southwestern Medical Center
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan Q2.S.D University of California, San Diego
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Q2.S.D Cold Spring Harbor Laboratory
Imaging signal transduction in single dendritic spines Yasuda, Ryohei Q2.Other Duke University
Young development of a novel PET ligand for detecting oxytocin receptors in brain Young, Larry Q2.Other Emory University
Brain lipid rafts in cholesterol biosynthesis disorders Yu, Hongwei Q2.Other Medical College of Wisconsin
High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution Zador, Anthony Q2.Other Cold Spring Harbor Laboratory
BDNF secretion and neural precursor migration Zhao, Xuesong Q2.Other Dana-Farber Cancer Institute
Functional analysis of neurexin IV in Drosophila Zipursky, Larry Q2.Other University of California, Los Angeles
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Q2.S.D Baylor College of Medicine