Loss of Skills and Onset Patterns in Neurodevelopmental Disorders: Understanding the Neurobiological Mechanisms Announcement

Topic	Topic Description
Date	February 19, 2016
Time:	9:00 a.m. to 5:00 p.m. Eastern
Place:	National Institute of Mental Health 6001 Executive Boulevard Bethesda, MD 20850
Webcast:	http://videocast.nih.gov.
Agenda:	To discuss the state of the science with regard to onset patterns in ASD and related disorders, including developmental regression, and the biological mechanisms that may account for these onset patterns. Consideration will be given to model systems and cutting-edge methods that may afford opportunities for a better understanding of the neurobiological pathways that result in deviation from typical developmental trajectories or loss of previously-attained developmental or cognitive skills. The goal of the workshop will be to identify research gap areas and opportunities. Ultimately, a better understanding of the mechanisms underlying onset patterns in neurodevelopmental disorders may lead to the identification of targets for efficacious prevention and treatment strategies.
General Information:	Listen-Only Conference Call Access: Dial: 800-369-2126. Access code: 2193178. For technical problems with the webcast or conference call, please send an e-mail to IACCPublicInquiries@mail.nih.gov, or by phone 415-652-8023.

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Time	Event
9:00 a.m.	Welcome and Introductions Audrey Thurm, Ph.D. Staff Scientist, Pediatrics and Developmental Neuroscience Branch National Institute of Mental Health Ann Wagner, Ph.D. Chief, Neurobehavioral Mechanisms of Mental Disorders Branch Division of Translational Research National Institute of Mental Health
9:10	Goals of the Workshop (TBD)
9:15	Session 1: Normative Development and Worsening/Declining Onset Patterns in Neurodevelopment Lonnie Zwaigenbaum, M.D., Chair Associate Professor and Director of Autism Research University of Alberta
9:20	Regression (NT and NDDs), the Importance of Timing and Cross-Syndrome Comparisons Annette Karmiloff-Smith, Ph.D. Department of Psychological Sciences University of London
9:40	Regression in Autism Spectrum Disorders Kasia Chawarska, Ph.D. Associate Professor, Child Study Center and Pediatrics Yale University
10:00	Early Brain Development in Autism: Neuroimaging Studies of the First Years of Life Jason Wolff, Ph.D. Assistant Professor, Educational Psychology University of Minnesota
10:20	Panel Discussion Discussant: Lonnie Zwaigenbaum, M.D.
10:50	Break
11:00	Session 2: How Can We Explore the Biological Basis for Regression Observed in Young Children? Jeff Neul, M.D., Ph.D., Chair Chief, Division of Child Neurology Professor and Vice Chair Department of Neurosciences University of California, San Diego
11:05	Modeling Rett Syndrome in a Dish – Ideas about Disease Regression Alysson Muotri, Ph.D. Associate Professor UCSD Stem Cell Program, School of Medicine University of California, San Diego
11:25	Shaping Brain Circuits by Experience: Uncovering Aberrant Plasticity in Mouse Models of Rett Syndrome Keerthi Krishnan, Ph.D. Research Investigator Department of Neuroscience Cold Spring Harbor Laboratory
11:45	Using the Visual System as a Means to Quantitatively Evaluate Cortical Function and Cognitive Performance in Rett Syndrome Charles Nelson, Ph.D. Professor of Pediatrics and Neuroscience Harvard Medical School Richard David Scott Chair in Pediatric Developmental Medicine Research Boston Children’s Hospital
12:05 p.m.	Panel Discussion Discussant: Elliott Sherr, M.D., Ph.D., Professor of Neurology, Pediatrics, University of California, San Francisco
12:40	Lunch
1:40	Session 3: Moving Forward with Linking Biology to Clinical Observation Elizabeth Powell, Ph.D., Chair Associate Professor Department of Anatomy and Neurobiology University of Maryland
1:45	Modeling the Social Brain: Developing Preclinical Assays of Symptom Onset Patterns Jill Silverman, Ph.D. Assistant Professor MIND Institute and Department of Psychiatry and Behavioral Sciences University of California Davis School of Medicine
2:05	Mouse Brain Imaging Jason Lerch, Ph.D. Senior Scientist, Associate Professor in Medical Biophysics University of Toronto
2:25	Panel Discussion Discussant: Eric Morrow, M.D., Ph.D., Associate Professor of Biology and Psychiatry, Brown University Discussant: Sharon Juliano, Ph.D., Professor, Neuroscience and Molecular Biology, Uniformed Services University of the Health Sciences Discussant: Karen Parker, Ph.D., Associate Professor, Department of Psychiatry and Behavioral Sciences, Stanford University
3:10	Break
3:20	Session 4: Bringing it all Together and Back to ASD Panel Discussion (Session Chairs and Presenters)
4:30	Next steps and Closing Remarks Audrey Thurm, Ph.D. Staff Scientist, Pediatrics and Developmental Neuroscience Branch National Institute of Mental Health Ann Wagner, Ph.D. Chief, Neurobehavioral Mechanisms of Mental Disorders Branch Division of Translational Research National Institute of Mental Health
5:00	Adjournment

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• Loss of Skills Workshop Full Slide Set (PDF 30 MB)

Presentation	Presenter(s)
Regression (NT and NDDs), the Importance of Timing and Cross-Syndrome Comparisons (PDF – 1 MB)	Annette Karmiloff-Smith, Ph.D., Department of Psychological Sciences, University of London
Modeling Rett Syndrome in a Dish – Ideas about Disease Regression (PDF – 26 MB)	Alysson Muotri, Ph.D., Associate Professor, UCSD Stem Cell Program, School of Medicine, University of California, San Diego
Shaping Brain Circuits by Experience: Uncovering Aberrant Plasticity in Mouse Models of Rett Syndrome (PDF – 1 MB)	Keerthi Krishnan, Ph.D., Research Investigator, Department of Neuroscience, Cold Spring Harbor Laboratory
Using the Visual System as a Means to Quantitatively Evaluate Cortical Function and Cognitive Performance in Rett Syndrome (PDF – 575 KB)	Charles Nelson, Ph.D., Professor of Pediatrics and Neuroscience, Harvard Medical School, Richard David Scott Chair in Pediatric Developmental Medicine Research, Boston Children’s Hospital
Moving Forward with Linking Biology to Clinical Observation (PDF – 381 KB)	Elizabeth Powell, Ph.D., Chair, Associate Professor, Department of Anatomy and Neurobiology, University of Maryland
Bringing it all Together and Back to ASD (PDF – 62 KB)	Panel Discussion, Session Chairs and Presenters

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