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Summary of Advances Cover 2010

Summary of Advances

In Autism Spectrum Disorder Research

2010

Appendices

Citation List – Articles Selected for the 2010 Summary of Advances

Question 1: When Should I Be Concerned?

King TM, Tandon SD, Macias MM, Healy JA, Duncan PM, Swigonski NL, Skipper SM, Lipkin PH. Implementing developmental screening and referrals: lessons learned from a national project. Pediatrics. 2010 Feb;125(2):350-60. [PMID: 20100754]

Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, Church DM, Crolla JA, Eichler EE, Epstein CJ, Faucett WA, Feuk L, Friedman JM, Hamosh A, Jackson L, Kaminsky EB, Kok K, Krantz ID, Kuhn RM, Lee C, Ostell JM, Rosenberg C, Scherer SW, Spinner NB, Stavropoulos DJ, Tepperberg JH, Thorland EC, Vermeesch JR, Waggoner DJ, Watson MS, Martin CL, Ledbetter DH. Consensus statement: Chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet. 2010 May 14;86(5):749-64. [PMID: 20466091]

Oller DK, Niyogi P, Gray S, Richards JA, Gilkerson J, Xu D, Yapanel U, Warren SF. Automated vocal analysis of naturalistic recordings from children with autism, language delay, and typical development. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13354-9. [PMID: 20643944]

Ozonoff S, Iosif AM, Baguio F, Cook IC, Hill MM, Hutman T, Rogers SJ, Rozga A, Sangha S, Sigman M, Steinfeld MB, Young GS. A prospective study of the emergence of early behavioral signs of autism. J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):256-66.e1-2. [PMID: 20410715]

Question 2: How Can I Understand What Is Happening?

Buie T, Campbell DB, Fuchs, III GJ, Furuta GT, Levy J, VandeWater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010 Jan; 125: S1 - S18. [PMID: 20048083]

Buie T, Fuchs GJ 3rd, Furuta GT, Kooros K, Levy J, Lewis JD, Wershil BK, Winter H. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010 Jan;125(Suppl 1):S19-29. [PMID: 20048084]

Ecker C, Marquand A, Mourao-Miranda J, Johnston P, Daly EM, Brammer MJ, Maltezos S, Murphy CM, Robertson D, Williams SC, Murphy DG. Describing the brain in autism in five dimensions—magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approach. J Neurosci. 2010 Aug11;30(32):10612-23. [PMID: 20702694]

Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, Tassone F, Pessah IN. Mitochondrial dysfunction in autism. JAMA. 2010 Dec 1;304(21):2389-96. [PMID: 21119085]

Kaiser MD, Hudac CM, Shultz S, Lee SM, Cheung C, Berken AM, Deen B, Pitskel NB, Sugrue DR, Voos AC, Saulnier CA, Ventola P, Wolf JM, Klin A, Vander Wyk BC, Pelphrey KA. Neural signatures of autism. Proc Natl Acad Sci USA. 2010 Dec 7;107(49):21223-8. [PMID: 21078973]

Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12;143(4):527-39. [PMID: 21074045]

Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci. 2010 Mar 24;30(12):4419-27. [PMID: 20335478]

Question 3: What Caused This To Happen and Can It Be Prevented?

Berkel S, Marshall CR, Weiss B, Howe J, Roeth R, Moog U, Endris V, Roberts W, Szatmari P, Pinto D, Bonin M, Riess A, Engels H, Sprengel R, Scherer SW, Rappold GA. Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet. 2010 Jun;42(6):489-91. [PMID: 20473310]

Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN. Blood mercury concentrations in CHARGE Study children with and without autism. Environ Health Perspect. 2010 Jan;118(1):161-6. [PMID: 20056569]

Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature. 2010 Jul 15;466(7304):368-72. [PMID: 20531469]

Scott-van Zeeland AA, Abrahams BS, Alvarez-Retuerto AI, Sonnenblick LI, Rudie JD, Ghahremani D, Mumford JA, Poldrack RA, Dapretto M, Geschwind DH, Bookheimer SY. Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Sci Transl Med. 2010 Nov 3;2(56)56ra80. [PMID: 21048216]

Question 4: Which Treatments and Interventions Will Help?

Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J. Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics. 2010 Jan;125(1):e17-23. [PMID: 19948568]

Kasari C, Gulsrud AC, Wong C, Kwon S, Locke J. Randomized controlled caregiver mediated joint engagement intervention for toddlers with autism. J Autism Dev Disord. 2010 Sep;40(9):1045-56. [PMID: 20145986]

Odom S, Collet-Klingenberg L, Rogers SJ, Hatton DD. Evidence-based practices in interventions for children and youth with autism spectrum disorders. Preventing School Failure. 2010 May;54(4):275-82.

Odom SL, Boyd BA, Hall LJ, Hume K. Evaluation of comprehensive treatment models for individuals with autism spectrum disorders. J Autism Dev Disord. 2010 Apr;40(4):425-36. [PMID: 19633939]

Question 5: Where Can I Turn For Services?

Wise MD, Little AA, Holliman JB, Wise PH, Wang CJ. Can state early intervention programs meet the increased demand of children suspected of having autism spectrum disorders? J Dev Behav Pediatr. 2010 Jul Aug;31(6):469-76. [PMID: 20585267]

Question 6: What Does the Future Hold, Particularly for Adults?

No articles were selected from Question 6. For a list of articles that were nominated in this category, see the Full Listing of Nominated Articles.

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Rice C, Nicholas J, Baio J, Pettygrove S, Lee LC, Van Naarden Braun K, Doernberg N, Cunniff C, Newschaffer C, Meaney FJ, Charles J, Washington A, King L, Kolotos M, Mancilla K, Ervis CA, Carpenter L, Yeargin-Allsopp M. Changes in autism spectrum disorder prevalence in 4 areas of the United States. Disab Health J. 2010 Jul;3(3):186-201. [Link: Disability and Health Journal]

Full Listing of Nominated Articles

Question 1: When Should I Be Concerned?

Chowdhury M, Aman MG, Scahill L, Swiezy N, Arnold LE, Lecavalier L, Johnson C, Handen B, Stigler K, Bearss K, Sukhodolsky D, McDougle CJ. The Home Situations Questionnaire-PDD version: factor structure and psychometric properties. J Intellect Disabil Res. 2010 Mar;54(3):281-91. [PMID: 20377705]

Selected Article
King TM, Tandon SD, Macias MM, Healy JA, Duncan PM, Swigonski NL, Skipper SM, Lipkin PH. Implementing developmental screening and referrals: lessons learned from a national project. Pediatrics. 2010 Feb;125(2):350-60. [PMID: 20100754]

Mandell DS, Morales KH, Xie M, Lawer LJ, Stahmer AC, Marcus SC. Age of diagnosis among Medicaid-enrolled children with autism, 2001-2004. Psychiatr Serv. 2010 Aug;61(8):822-9. [PMID: 20675842]

Selected Article
Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, Church DM, Crolla JA, Eichler EE, Epstein CJ, Faucett WA, Feuk L, Friedman JM, Hamosh A, Jackson L, Kaminsky EB, Kok K, Krantz ID, Kuhn RM, Lee C, Ostell JM, Rosenberg C, Scherer SW, Spinner NB, Stavropoulos DJ, Tepperberg JH, Thorland EC, Vermeesch JR, Waggoner DJ, Watson MS, Martin CL, Ledbetter DH. Consensus statement: Chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet. 2010 May 14;86(5):749-64. [PMID: 20466091]

Norris M, Lecavalier L. Screening accuracy of Level 2 autism spectrum disorder rating scales: A review of selected instruments. Autism. 2010 Jul;14(4):263-84. [PMID: 20591956]

Selected Article
Oller DK, Niyogi P, Gray S, Richards JA, Gilkerson J, Xu D, Yapanel U, Warren SF. Automated vocal analysis of naturalistic recordings from children with autism, language delay, and typical development. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13354-9. [PMID: 20643944]

Selected Article
Ozonoff S, Iosif AM, Baguio F, Cook IC, Hill MM, Hutman T, Rogers SJ, Rozga A, Sangha S, Sigman M, Steinfeld MB, Young GS. A prospective study of the emergence of early behavioral signs of autism. J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):256-66.e1-2. [PMID: 20410715]

Question 2: How Can I Understand What Is Happening?

Selected Article
Buie T, Campbell DB, Fuchs, III GJ, Furuta GT, Levy J, VandeWater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010 Jan; 125: S1 - S18. [PMID: 20048083]

Selected Article
Buie T, Fuchs GJ 3rd, Furuta GT, Kooros K, Levy J, Lewis JD, Wershil BK, Winter H. Recommendations for evaluation and treatment of common gastrointestinal problems in children with ASDs. Pediatrics. 2010 Jan;125(Suppl 1):S19-29. [PMID: 20048084]

Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Proc Natl Acad Sci USA. 2010 Oct 12;107(41):17668-73. [PMID: 20876107]

Chao HR, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. Dysfunction in GABA signaling mediates autism-like stereotypies and rett syndrome phenotypes. Nature. 2010 Nov 11;468(7321):263-9. [PMID: 21068835]

Selected Article
Ecker C, Marquand A, Mourao-Miranda J, Johnston P, Daly EM, Brammer MJ, Maltezos S, Murphy CM, Robertson D, Williams SC, Murphy DG. Describing the brain in autism in five dimensions–magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approach. J Neurosci. 2010 Aug11;30(32):10612-23. [PMID: 20702694]

Selected Article
Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, Tassone F, Pessah IN. Mitochondrial dysfunction in autism. JAMA. 2010 Dec 1;304(21):2389-96. [PMID: 21119085]

Selected Article
Kaiser MD, Hudac CM, Shultz S, Lee SM, Cheung C, Berken AM, Deen B, Pitskel NB, Sugrue DR, Voos AC, Saulnier CA, Ventola P, Wolf JM, Klin A, Vander Wyk BC, Pelphrey KA. Neural signatures of autism. Proc Natl Acad Sci USA. 2010 Dec 7;107(49):21223-8. [PMID: 21078973]

Selected Article
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12;143(4):527-39. [PMID: 21074045]

Mostafa GA, El-Hadidi ES, Hewedi DH, Abdou MM. Oxidative stress in Egyptian children with autism: relation to autoimmunity. J Neuroimmun. 2010 Feb 26;219(1-2):114-8. [PMID: 20036015]

Palmieri L, Papaleo V, Porcelli V, Scarcia P, Gaita L, Sacco R, Hager J, Rousseau F, Curatolo P, Manzi B, Militerni R, Bravaccio C, Trillo S, Schneider C, Melmed R, Elia M, Lenti C, Saccani M, Pascucci T, Puglisi-Allegra S, Reichelt KL, Persico AM. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry. 2010 Jan;15(1):38-52. [PMID: 18607376]

Palmieri L, Persico AM. Mitochondrial dysfunction in autism spectrum disorders: Cause or effect? Biochim Biophys Acta. 2010 June - July;1797(6-7):1130-1137. [PMID: 20441769]

Selected Article
Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci. 2010 Mar 24;30(12):4419-27. [PMID: 20335478]

Zikopoulos B, Barbas H. Changes in prefrontal axons may disrupt the network in autism. J Neurosci. 2010 Nov 3;30(44):14595-609. [PMID: 21048117]

Question 3: What Caused This To Happen and Can It Be Prevented?

Berkel S, Marshall CR, Weiss B, Howe J, Roeth R, Moog U, Endris V, Roberts W, Szatmari P, Pinto D, Bonin M, Riess A, Engels H, Sprengel R, Scherer SW, Rappold GA. Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat Genet. 2010 Jun;42(6):489-91. [PMID: 20473310]

Campbell DB, Warren D, Sutcliffe JS, Lee EB, Levitt P. Association of MET with social and communication phenotypes in individuals with autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):438-46. [PMID: 19548256]

Curtis JT, Hood AN, Chen Y, Cobb GP, Wallace DR. Chronic metals ingestion by prairie voles produces sex-specific deficits in social behavior: an animal model of autism. Behav Brain Res. 2010 Nov 12;213(1):42-9. [PMID: 20433873]

Gallagher CM, Goodman MS. Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002. J Toxicol Environ Health A. 2010;73(24):1665-77. [PMID: 21058170]

Girirajan S, Rosenfeld JA, Cooper GM, Antonacci F, Siswara P, Itsara A, Vives L, Walsh T, McCarthy SE, Baker C, Mefford HC, Kidd JM, Browning SR, Browning BL, Dickel DE, Levy DL, Ballif BC, Platky K, Farber DM, Gowans GC, Wetherbee JJ, Asamoah A, Weaver DD, Mark PR, Dickerson J, Garg BP, Ellingwood SA, Smith R, Banks VC, Smith W, McDonald MT, Hoo JJ, French BN, Hudson C, Johnson JP, Ozmore JR, Moeschler JB, Surti U, Escobar LF, El-Khechen D, Gorski JL, Kussmann J, Salbert B, Lacassie Y, Biser A, McDonald-McGinn DM, Zackai EH, Deardorff MA, Shaikh TH, Haan E, Friend KL, Fichera M, Romano C, Gécz J, DeLisi LE, Sebat J, King MC, Shaffer LG, Eichler EE. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Nat Genet. 2010 Mar;42(3):203-9. [PMID: 20154674]

Selected Article
Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN. Blood mercury concentrations in CHARGE Study children with and without autism. Environ Health Perspect. 2010 Jan;118(1):161-6. [PMID: 20056569]

Hunter JW, Mullen GP, McManus JR, Heatherly JM, Duke A, Rand JB. Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity. Dis Model Mech. 2010 May-Jun;3(5-6):366-76.[PMID: 20083577]

Johnson S, Hollis C, Kochhar P, Hennessy E, Wolke D, Marlow N. Autism spectrum disorders in extremely preterm children. J Pediatr. 2010 Apr;156(4):525-31.e2.[PMID: 20056232]

Keil A, Daniels JL, Forssen U, Hultman C, Cnattingius S, Söderberg KC, Feychting M, Sparen P. Parental autoimmune diseases associated with autism spectrum disorders in offspring. Epidemiology. 2010 Nov;21(6):805-8. [PMID: 20798635]

Kern JK, Geier DA, Adams JB, Geier MR. A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Biometals. 2010 Dec;23(6):1043-1051. [PMID: 20532957]

Lancet. Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 2010 Feb 6;375(9713):445.[PMID: 20137807]

Lichtenstein P, Carlstrom E, Rastam M, Gillberg C, Anckarsater H. The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am J Psychiatry. 2010 Nov;167(11):1357-63. [PMID: 20686188]

Lintas C, Altieri L, Lombardi F, Sacco R, Persico AM. Association of autism with polyomavirus infection in postmortem brains. J Neurovirol. 2010 Apr;16(2):141-9. [PMID: 20345322]

Olczak M, Duszczyk M, Mierzejewski P, Wierzba-Bobrowicz T, Majewska MD. Lasting neuropathological changes in rat brain after intermittent neonatal administration of thimerosal. Folia Neuropathol.2010;48(4):258-69. [PMID: 21225508]

Selected Article
Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature. 2010 Jul 15;466(7304):368-72. [PMID: 20531469]

Price CS, Thompson WW, Goodson B, Weintraub ES, Croen LA, Hinrichsen VL, Marcy M, Robertson A, Eriksen E, Lewis E, Bernal P, Shay D, Davis RL, DeStefano F. Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism. Pediatrics. 2010 Oct;126(4):656-64. [PMID: 20837594]

Schieve LA, Baio J, Rice CE, Durkin M, Kirby RS, Drews-Botsch C, Miller LA, Nicholas JS, Cunniff CM. Risk for cognitive deficit in a population-based sample of U.S. children with autism spectrum disorders: Variation by perinatal health factors. Disability and Health Journal. July 2010; 3(3) 202-212. [Link: Disability and Health Journal]

Selected Article
Scott-van Zeeland AA, Abrahams BS, Alvarez-Retuerto AI, Sonnenblick LI, Rudie JD, Ghahremani D, Mumford JA, Poldrack RA, Dapretto M, Geschwind DH, Bookheimer SY. Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Sci Transl Med. 2010 Nov 3;2(56)56ra80. [PMID: 21048216]

Shelton JF, Tancredit DJ, Hertz-Picciotto I. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Res. 2010 Feb;3(1):30-9. [PMID: 20143326]

Shoffner J, Hyams L, Langley GN, Cossette S, Mylacraine L, Dale J, Ollis L, Kuoch S, Bennett K, Aliberti A, Hyland K. Fever plus mitochondrial disease could be risk factors for autistic regression. J Child Neurol. 2010 Apr;25(4):429-34.[PMID: 19773461]

Smith MJ, Woods CR. On-time vaccine receipt in the first year does not adversely affect neuropsychological outcomes. Pediatrics. 2010 Jun;125(6):1134-41. [PMID: 20498176]

Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK. Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J Proteome Res. 2010 Jun 4;9(6):2996-3004. [PMID: 20337404]

Question 4: Which Treatments and Interventions Will Help?

Arnold LE, Farmer C, Kraemer HC, Davies M, Witwer A, Chuang S, DiSilvestro R, McDougle CJ, McCracken J, Vitiello B, Aman MG, Scahill L, Posey DJ, Swiezy NB. Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability. J Child Adolesc Psychopharmacol. 2010 Apr;20(2):83-93. [PMID: 20415603]

Selected Article
Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Donaldson A, Varley J. Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics. 2010 Jan;125(1):e17-23. [PMID: 19948568]

Frankel F, Myatt R, Sugar C, Whitham C, Gorospe CM, Laugeson E. A randomized controlled study of parent-assisted Children's Friendship Training with children having autism spectrum disorders. J Autism Dev Disord. 2010 Jul;40(7):827-42. [PMID: 20058059]

Selected Article
Kasari C, Gulsrud AC, Wong C, Kwon S, Locke J. Randomized controlled caregiver mediated joint engagement intervention for toddlers with autism. J Autism DevDisord. 2010 Sep;40(9):1045-56. [PMID: 20145986]

McCracken JT, Aman MG, McDougle CJ, Tierney E, Shiraga S, Whelan F, Arnold LE, Posey D, Ritz L, Vitiello B, Scahill L. Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity. J Child Adolesc Psychopharmacol. 2010 Feb;20(1):1-5. [PMID: 20166790]

Selected Article
Odom S, Collet-Klingenberg L, Rogers SJ, Hatton DD. Evidence-based practices in interventions for children and youth with autism spectrum disorders. Preventing School Failure. 2010 May;54(4):275-82.

Selected Article
Odom SL, Boyd BA, Hall LJ, Hume K. Evaluation of comprehensive treatment models for individuals with autism spectrum disorders. J Autism Dev Disord. 2010 Apr;40(4):425-36. [PMID: 19633939]

Question 5: Where Can I Turn For Services?

Brookman-Frazee L, Taylor, R, Garland, A. Characterizing Community-Based Mental Health Services for Children with Autism Spectrum Disorders and Disruptive Behavior Problems. J Autism Dev Disord. 2010 Oct;40(10): 1188-1201. [PMID: 20204690]

Wehmeyer, MI, Shogren KA, Smith TEC, Zager D, Simpton R. Research-Based Principles and Practices for Educating Students with Autism: Self-Determination and Social Interactions. Education and Training in Autism and Developmental Disabilities. 2010 45(4): 475-86.

Young J, Corea C, Kimani J, Mandell D. Autism Spectrum Disorders (ASDs) Services: Final Report on Environmental Scan. Prepared for the Centers for Medicare & Medicaid Services. 2010 Mar 9. [Link: Available here (PDF – 2 MB)]

Selected Article
Wise MD, Little AA, Holliman JB, Wise PH, Wang CJ. Can state early intervention programs meet the increased demand of children suspected of having autism spectrum disorders? J Dev Behav Pediatr. 2010 Jul Aug;31(6):469-76. [PMID: 20585267]

Question 6: What Does the Future Hold, Particularly for Adults?

Chowdhury M, Benson BA, Hillier A. Changes in Restricted Repetitive Behaviors with age: A study of high-functioning adults with Autism Spectrum Disorders. Research in Autism Spectrum Disorders. 2010 April-June;4(2):210-216. [Link: ScienceDirect]

LeBel J, Huckshorn KA, Caldwell, B. Restraint use in residential programs: why are best practices ignored? Child Welfare.2010;89(2):169-87. [PMID: 20857886]

McDonough, JT, Revell, G. Accessing employment supports in the adult system for transitioning youth with autism spectrum disorders. Journal of Vocational Rehabilitation. 2010;32(2):89-100.

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Durkin MS, Maenner MJ, Meaney FJ, Levy SE, DiGuiseppi C, Nicholas JS, Kirby RS, Pinto-Martin JA, Schieve LA. Socioeconomic inequality in the prevalence of autism spectrum disorder: evidence from a U.S. cross-sectional study. PLoS One. 2010 Jul 12;5(7):e11551. [PMID: 20634960]

Gilberg C, Billstedt E, Sundh V, Gilbert IC. Mortality in autism: a prospective longitudinal community-based study. J Autism Dev Disord. 2010 Mar;40 (3): 352-57. [PMID: 19838782]

Liu KY, King M, Bearman PS. Social influence and the autism epidemic. AJS. 2010 Mar;115(5):1387-434. [PMID: 20503647]

Mazumdar S, King M, Liu KY, Zerubavel N, Bearman P. The spatial structure of autism in California, 1993-2001. Health Place. 2010 May;16(3):539-46.[PMID: 20097113]

McDonald ME, Paul JF. Timing of increased autistic disorder cumulative incidence. Environ Sci Technol. 2010 Mar 15;44(6):2112-8. [PMID: 20158232]

Selected Article
Rice C, Nicholas J, Baio J, Pettygrove S, Lee LC, Van Naarden Braun K, Doernberg N, Cunniff C, Newschaffer C, Meaney FJ, Charles J, Washington A, King L, Kolotos M, Mancilla K, Ervis CA, Carpenter L, Yeargin-Allsopp M. Changes in autism spectrum disorder prevalence in 4 areas of the United States. Disabil Health J. July 2010;3(3):186-201. [Link: Disability and Health Journal]

Saemundsen E, Juliusson H, Hjaltested S, Gunnarsdottir T, Halldorsdottir T, Hreidarsson S, Magnusson P. Prevalence of autism in an urban population of adults with severe intellectual disabilities - a preliminary study. J Intellect Disabil Res. 2010 Aug;54(8):727-35.[PMID: 20633201]

van Meter KC, Christiansen LE, Delwiche LD, Azari R, Carpenter TE, Hertz-Picciotto I. Geographic distribution of autism in California: a retrospective birth cohort analysis. Autism Res. 2010 Feb;3(1):19-29. [PMID: 20049980]

About the IACC

The Interagency Autism Coordinating Committee (IACC) was established by Congress under the Combating Autism Act of 2006 (CAA) to provide advice to the Secretary of Health and Human Services (HHS) and coordinate all efforts within HHS concerning autism spectrum disorders (ASD).

As mandated by law, the IACC has a membership composed of Federal officials from agencies involved in autism research and services and public members, including people with ASD, parents of children and adults with ASD, and members of the autism advocacy and research community. The diversity of the Committee ensures that a broad range of views and opinions is reflected and discussed in a public forum.

Under the CAA, the IACC is required to (1) develop and annually update a Strategic Plan for ASD research, (2) develop and annually update a summary of advances in ASD research, and (3) monitor federal activities related to ASD.

In developing and updating the IACC Strategic Plan for Autism Spectrum Disorder Research, first released in 2009 and subsequently updated in 2010 and 2011, the IACC has laid out a framework for the pursuit of critical biomedical and services research. Through activities such as public meetings and workshops, publication of an annual Summary of Advances in ASD Research, dissemination of information regarding ASD research and IACC activities, gathering of public input and coordination of Federal activities related to autism, the IACC continues in its effort to provide guidance to the Department of Health and Human Services and to reach out to the broader autism community to find ways to work together to help people with autism and their families.

IACC Member Roster

Chair

  • Thomas R. Insel, M.D.
    Director
    National Institute of Mental Health
    National Institutes of Health
    Bethesda, Maryland

Federal Members

  • James F. Battey, M.D., Ph.D.
    Director
    National Institute on Deafness and Other Communication Disorders
    National Institutes of Health
    Bethesda, Maryland
  • Linda Birnbaum, Ph.D.
    Director
    National Institute of Environmental Health Sciences
    National Institutes of Health
    Research Triangle Park, North Carolina
  • Ellen W. Blackwell, M.S.W.
    Division of Community and Institutional Services
    Disabled and Elderly Health Programs Group
    Center for Medicaid and State Operations
    Centers for Medicare & Medicaid Services
    Baltimore, Maryland
  • Coleen Boyle, Ph.D.
    Acting Director
    National Center on Birth Defects and Developmental Disabilities
    Centers for Disease Control and Prevention
    Atlanta, Georgia
  • Henry Claypool
    Director
    Office on Disability
    U.S. Department of Health and Human Services
    Washington, DC
  • Francis S. Collins, M.D., Ph.D.
    Director
    National Institutes of Health
    Bethesda, Maryland
  • Alan E. Guttmacher, M.D.
    Acting Director
    Eunice Kennedy Shriver National Institute of Child Health and Human Development
    National Institutes of Health
    Bethesda, Maryland
  • Gail R. Houle, Ph.D. 
    Associate Division Director Research-to-Practice Division Early Childhood Programs
    Office of Special Education Programs
    U.S. Department of Education
    Washington, DC
  • Larke N. Huang, Ph.D. 
    Senior Advisor on Children Office of the Administrator
    Substance Abuse and Mental Health
    Services Administration
    Rockville, Maryland
  • Walter J. Koroshetz, M.D.
    Deputy Director
    National Institute of Neurological Disorder and Stroke
    National Institutes of Health
    Bethesda, Maryland
  • Sharon Lewis
    Commissioner
    Administration on Developmental Disabilities
    Administration for Children and Families
    Washington, DC
  • Peter van Dyck, M.D., M.P.H. 
    Associate Administrator
    Maternal and Child Health
    Health Resources and Services Administration
    Rockville, Maryland

Public Members

  • Geraldine Dawson, Ph.D. 
    Chief Science Officer Autism Speaks
    New York, New York
  • Gerald D. Fischbach, M.D.
    Scientific Director
    Simons Foundation
    Autism Research Initiative
    New York, New York
  • Lee Grossman 
    President and CEO
    Autism Society
    Bethesda, Maryland
  • Yvette M. Janvier, M.D.
    Medical Director
    Children’s Specialized Hospital
    Toms River, New Jersey
  • Christine M. McKee, J.D.
    Rockville, Maryland
  • Ari Ne'eman
    Founding President
    Autistic Self-Advocacy Network
    Washington, DC
  • Lyn Redwood, R.N., M.S.N.
    Co-Founder and Executive Director
    Coalition for Safe Minds
    Tyrone, Georgia
  • Denise D. Resnik
    Board Member and Co-Founder
    Southwest Autism Research and
    Resource Center
    Phoenix, Arizona
  • Stephen M. Shore, Ed.D.
    Executive Director
    Autism Spectrum Consulting and Assistant Professor of Special Education
    Adelphi University
    Newton, Massachusetts
  • Alison Tepper Singer, M.B.A.
    President
    Autism Science Foundation
    New York, New York
  • Marjorie Solomon, Ph.D., M.B.A. 
    Assistant Clinical Professor
    University of California, Davis
    School of Medicine and
    M.I.N.D. Institute
    Sacramento, California

Office of Autism Research Coordination (OARC) Staff List

  • Susan A. Daniels, Ph.D.
    Acting Director
  • Elizabeth M. Baden, Ph.D.
    Policy Analyst
  • Erin H. Bryant, M.J.
    Science Writer/Editor
  • Sara E. Dodson, Ph.D.
    AAAS Science & Technology
    Policy Fellow/Health Scientist
  • Nicole Jones, B.B.A.
    Web Developer
  • Miguelina Perez
    Management Analyst

Cover Design
NIH Medical Arts Branch

Copyright Information
All material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.

Suggested Citation
Interagency Autism Coordinating Committee (IACC). 2013 IACC Summary of Advances in Autism Spectrum Disorder Research. April 2014. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: http://iacc.hhs.gov/publications/summary-of-advances/2013/.

Appendices

 
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