Question 1: When Should I Be Concerned?

• Approaches to enhancing the early detection of autism spectrum disorders: a systematic review of the literature
• Validation of the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F)

Question 2: How Can I Understand What Is Happening?

• Synaptic, transcriptional and chromatin genes disrupted in autism
• Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection
• A higher mutational burden in females supports a “female protective model” in neurodevelopmental disorders
• Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis
• Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

Question 3: What Caused This to Happen and Can It Be Prevented?

• Most genetic risk for autism resides with common variation
• Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay
• The contribution of de novo coding mutations to autism spectrum disorder
• The familial risk of autism
• Vaccines are not associated with autism: an evidencebased meta-analysis of case-control and cohort studies

Question 4: Which Treatments and Interventions Will Help?

• Caregiver-mediated intervention for low-resourced preschoolers with autism: an RCT
• Parent-implemented social intervention for toddlers with autism: an RCT

Question 5: Where Can I Turn for Services?

• Costs of autism spectrum disorders in the United Kingdom and the United States
• Economic burden of childhood autism spectrum disorders

Question 6: What Does the Future Hold, Particularly for Adults?

• A longitudinal examination of 10-year change in vocational and educational activities for adults with autism spectrum disorders

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

• Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2010
• The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism
• Potential impact of DSM5 criteria on autism spectrum disorder prevalence estimates