Articles Selected for the 2022 Summary Of Advances

Screening and Diagnosis

Barbaresi W, Cacia J, Friedman S, Fussell J, Hansen R, Hofer J, Roizen N, Stein REK, Vanderbilt D, Sideridis G. Clinician Diagnostic Certainty and the Role of the Autism Diagnostic Observation Schedule in Autism Spectrum Disorder Diagnosis in Young Children. JAMA Pediatr 2022 Dec 1;176(12):1233-1241. PMID: 36251287]

Burrows CA, Grzadzinski RL, Donovan K, Stallworthy IC, Rutsohn J, St John T, Marrus N, Parish-Morris J, MacIntyre L, Hampton J, Pandey J, Shen MD, Botteron KN, Estes AM, Dager SR, Hazlett HC, Pruett JR Jr, Schultz RT, Zwaigenbaum L, Truong KN, Piven J, Elison JT; IBIS Network. A Data-Driven Approach in an Unbiased Sample Reveals Equivalent Sex Ratio of Autism Spectrum Disorder-Associated Impairment in Early Childhood. Biol Psychiatry. 2022 Oct 15;92(8):654-662. [PMID: 35965107]

Reisinger DL, Hines E, Raches C, Tang Q, James C, Keehn RM. Provider and Caregiver Satisfaction with Telehealth Evaluation of Autism Spectrum Disorder in Young Children During the COVID-19 Pandemic. J Autism Dev Disord. 2022 Dec;52(12):5099-5113. [PMID: 35579789]

Sheldrick RC, Carter AS, Eisenhower A, Mackie TI, Cole MB, Hoch N, Brunt S, Pedraza FM. Effectiveness of Screening in Early Intervention Settings to Improve Diagnosis of Autism and Reduce Health Disparities. JAMA Pediatr. 2022 Mar 1;176(3):262-269. [PMID: 34982099]

Biology

Gandal MJ, Haney JR, Wamsley B, Yap CX, Parhami S, Emani PS, Chang N, Chen GT, Hoftman GD, de Alba D, Ramaswami G, Hartl CL, Bhattacharya A, Luo C, Jin T, Wang D, Kawaguchi R, Quintero D, Ou J, Wu YE, Parikshak NN, Swarup V, Belgard TG, Gerstein M, Pasaniuc B, Geschwind DH. Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD. Nature. 2022 Nov;611(7936):532-539. Epub 2022 Nov 2. [PMID: 36323788]

Gates JA, Gerber AH, Miller CE, Lerner MD. Quantifying social skill deficits and strengths profiles in autistic youth. Child Dev. 2023 May;94(3):659-673. Epub 2022 Dec 27. [PMID: 36573397]

Girault JB, Donovan K, Hawks Z, Talovic M, Forsen E, Elison JT, Shen MD, Swanson MR, Wolff JJ, Kim SH, Nishino T, Davis S, Snyder AZ, Botteron KN, Estes AM, Dager SR, Hazlett HC, Gerig G, McKinstry R, Pandey J, Schultz RT, St John T, Zwaigenbaum L, Todorov A, Truong Y, Styner M, Pruett JR Jr, Constantino JN, Piven J; IBIS Network. Infant Visual Brain Development and Inherited Genetic Liability in Autism. Am J Psychiatry. 022 Aug;179(8):573-585. [PMID: 35615814]

Northrup JB, Goodwin MS, Peura CB, Chen Q, Taylor BJ, Siegel MS, Mazefsky CA. Mapping the time course of overt emotion dysregulation, self-injurious behavior, and aggression in psychiatrically hospitalized autistic youth: A naturalistic study. Autism Res. 2022 Oct;15(10):1855-1867. [PMID: 35751466]

Pickles A, Wright N, Bedford R, Steiman M, Duku E, Bennett T, Georgiades S, Kerns CM, Mirenda P, Smith IM, Ungar WJ, Vaillancourt T, Waddell C, Zaidman-Zait A, Zwaigenbaum L, Szatmari P, Elsabbagh M. Pathways in ASD Study Team. Predictors of language regression and its association with subsequent communication development in children with autism. J Child Psychol Psychiatry. 2022 Nov;63(11):1243-1251. Epub 2022 Jan 30. [PMID: 35098539]

Genetic and Environmental Factors

Havdahl A, Wootton RE, Leppert B, Riglin L, Ask H, Tesli M, Bugge Askeland R, Hannigan LJ, Corfield E, Øyen AS, Andreassen OA, Tilling K, Davey Smith G, Thapar A, Reichborn-Kjennerud T, Stergiakouli E. Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa).. JAMA Psychiatry. 2022 Aug 1;79(8):799-810. [PMID: 35793100]

Interventions

Panganiban J, Kasari C. Super responders: Predicting language gains from JASPER among limited language children with autism spectrum disorder. Autism Res. 2022 Aug;15(8):1565-1575. [PMID: 35437928]

Services and Supports

Shenouda J, Barrett E, Davidow AL, Sidwell K, Halperin W, Silenzio VMB, Zahorodny W. Disparities in Early Intervention Program Participation by Children With Autism Spectrum Disorder in a US Metropolitan Area, 2006 to 2016. JAMA Pediatr. 2022 Sep 1;176(9):906-914. [PMID: 35849409]

Stadnick NA, Martinez K, Coleman KJ, Gizzo DP, Lane E, Lee N, Kuelbs CL, Aarons GA, Brookman-Frazee L. Mental health screening in pediatric primary care for children with autism. Autism.. 022 Jul;26(5):1305-1311. [PMID: 35105226]

Lifespan

Doherty M, Neilson S, O'Sullivan J, Carravallah L, Johnson M, Cullen W, Shaw SCK. Barriers to healthcare and self-reported adverse outcomes for autistic adults: a cross-sectional study. BMJ Open. 2022 Feb 22;12(2):e056904. [PMID: 35193921]

Forbes G, Kent R, Charman T, Baird G, Pickles A, Simonoff E. How do autistic people fare in adult life and can we predict it from childhood? Autism Res. 2022 Dec 15. [PMID: 36519265]

Jadav N, Bal VH. Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research. Autism Res. 2022 Nov;15(11):2112-2125. [PMID: 36054777]

Lee NR, McQuaid GA, Grosman HE, Jayaram S, Wallace GL. Vocational Outcomes in ASD: An Examination of Work Readiness Skills as well as Barriers and Facilitators to Employment Identified by Autistic Adults. J Autism Dev Disord. 2022 Nov 17:1–14. [PMID: 36394783]

Schott W, Tao S, Shea L. Co-occurring conditions and racial-ethnic disparities: Medicaid enrolled adults on the autism spectrum. Autism Res. 2022 Jan;15(1):70-85. [PMID: 34854249]

Shea L, Tao S, Marcus SC, Mandell D, Epstein AJ. Medicaid Disruption Among Transition-Age Youth on the Autism Spectrum. Med Care Res Rev. 2022 Aug;79(4):525-534. [PMID: 34632834]

Infrastructure and Prevalence

Shaw KA, McArthur D, Hughes MM, Bakian AV, Lee LC, Pettygrove S, Maenner MJ. Progress and Disparities in Early Identification of Autism Spectrum Disorder: Autism and Developmental Disabilities Monitoring Network, 2002-2016. J Am Acad Child Adolesc Psychiatry. 2022 Jul;61(7):905-914. [PMID: 34838692]

Full Listing of Nominated Articles (Selected Articles Appear *Red)

Screening and Diagnosis

*Barbaresi W, Cacia J, Friedman S, Fussell J, Hansen R, Hofer J, Roizen N, Stein REK, Vanderbilt D, Sideridis G. Clinician Diagnostic Certainty and the Role of the Autism Diagnostic Observation Schedule in Autism Spectrum Disorder Diagnosis in Young Children. JAMA Pediatr 2022 Dec 1;176(12):1233-1241. PMID: 36251287]

Bodfish JW, Lecavalier L, Harrop C, Dallman A, Kalburgi SN, Hollway J, Faldowski R, Boyd BA. Measuring the Functional Impact of Behavioral Inflexibility in Children with Autism Using the Behavioral Inflexibility Scale: Clinical Interview (BIS-CI). J Autism Dev Disord. 2022 Feb;52(2):782-790. [PMID: 33811282]

*Burrows CA, Grzadzinski RL, Donovan K, Stallworthy IC, Rutsohn J, St John T, Marrus N, Parish-Morris J, MacIntyre L, Hampton J, Pandey J, Shen MD, Botteron KN, Estes AM, Dager SR, Hazlett HC, Pruett JR Jr, Schultz RT, Zwaigenbaum L, Truong KN, Piven J, Elison JT; IBIS Network. A Data-Driven Approach in an Unbiased Sample Reveals Equivalent Sex Ratio of Autism Spectrum Disorder-Associated Impairment in Early Childhood. Biol Psychiatry. 2022 Oct 15;92(8):654-662. [PMID: 35965107]

Dursun OB, Turan B, Öðütlü H, Binici NC, Örengül AC, Alataþ E, Özdemir RM, Taþlýbeyaz E, Karaman S, Mukaddes NM, onbehalfofTurkish Autism Workgroup. A new model for recognition, referral, and follow-up of autism spectrum disorder: A nationwide program. Autism Research. 2022. 15(10), 1961–1970. [https://doi.org/10.1002/aur.2813]

*Reisinger DL, Hines E, Raches C, Tang Q, James C, Keehn RM. Provider and Caregiver Satisfaction with Telehealth Evaluation of Autism Spectrum Disorder in Young Children During the COVID-19 Pandemic. J Autism Dev Disord. 2022 Dec;52(12):5099-5113. [PMID: 35579789]

Rooney T, Stern YS, Hampton LH, Grauzer J, Hobson A, Levin A, Jones MK, Kaat AJ, Roberts MY. Screening for Autism in 2-Year-Old Children: The Application of the Systematic Observation of Red Flags to the Screening Tool for Autism in Toddlers and Young Children. Am J Speech Lang Pathol. 022 Nov 16;31(6):2759-2769. [PMID: 36306799]

Schaaf RC, Mailloux Z, Ridgway E, Berruti AS, Dumont RL, Jones EA, Leiby BE, Sancimino C, Yi M, Molholm S. Sensory Phenotypes in Autism: Making a Case for the Inclusion of Sensory Integration Functions. J Autism Dev Disord. 2022 Sep 27. [PMID: 36167886]

*Sheldrick RC, Carter AS, Eisenhower A, Mackie TI, Cole MB, Hoch N, Brunt S, Pedraza FM. Effectiveness of Screening in Early Intervention Settings to Improve Diagnosis of Autism and Reduce Health Disparities. JAMA Pediatr. 2022 Mar 1;176(3):262-269. [PMID: 34982099]

Wiggins LD, Tian LH, Rubenstein E, Schieve L, Daniels J, Pazol K, DiGuiseppi C, Barger B, Moody E, Rosenberg S, Bradley C, Hsu M, Robinson Rosenberg C, Christensen D, Crume T, Pandey J, Levy SE. Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case-control analysis replicated across two independent samples. Autism Res. 2022 Mar;15(3):539-550. [PMID: 34967132]

Biology

Ahmed E, Mansour A, Amer A. Screening of gastrointestinal symptoms and celiac disease in children with autism spectrum disorder. Egypt J Otolaryngol. 2022; 38, 81. [https://doi.org/10.1186/s43163-022-00270-6]

Baribeau DA, Vigod SN, Pullenayegum E, Kerns CM, Vaillancourt T, Duku E, Smith IM, Volden J, Zwaigenbaum L, Bennett T, Elsabbagh M, Zaidman-Zait A, Richard AE, Szatmari P. Developmental cascades between insistence on sameness behaviour and anxiety symptoms in autism spectrum disorder. Eur Child Adolesc Psychiatry. 2022 Jul 24. [PMID: 35871413]

Bradshaw J, Schwichtenberg AJ, Iverson JM. Capturing the complexity of autism: Applying a developmental cascades framework. Child Dev Perspect. 2022 Mar;16(1):18-26. [PMID: 36407945]

Che X, Hornig M, Bresnahan M, Stoltenberg C, Magnus P, Surén P, Mjaaland S, Reichborn-Kjennerud T, Susser E, Lipkin WI. Maternal mid-gestational and child cord blood immune signatures are strongly associated with offspring risk of ASD. Mol Psychiatry. 2022 Mar;27(3):1527-1541. [PMID: 34987169]

*Gandal MJ, Haney JR, Wamsley B, Yap CX, Parhami S, Emani PS, Chang N, Chen GT, Hoftman GD, de Alba D, Ramaswami G, Hartl CL, Bhattacharya A, Luo C, Jin T, Wang D, Kawaguchi R, Quintero D, Ou J, Wu YE, Parikshak NN, Swarup V, Belgard TG, Gerstein M, Pasaniuc B, Geschwind DH. Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD. Nature. 2022 Nov;611(7936):532-539. Epub 2022 Nov 2. [PMID: 36323788]

*Gates JA, Gerber AH, Miller CE, Lerner MD. Quantifying social skill deficits and strengths profiles in autistic youth. Child Dev. 2023 May;94(3):659-673. Epub 2022 Dec 27. [PMID: 36573397]

*Girault JB, Donovan K, Hawks Z, Talovic M, Forsen E, Elison JT, Shen MD, Swanson MR, Wolff JJ, Kim SH, Nishino T, Davis S, Snyder AZ, Botteron KN, Estes AM, Dager SR, Hazlett HC, Gerig G, McKinstry R, Pandey J, Schultz RT, St John T, Zwaigenbaum L, Todorov A, Truong Y, Styner M, Pruett JR Jr, Constantino JN, Piven J; IBIS Network. Infant Visual Brain Development and Inherited Genetic Liability in Autism. Am J Psychiatry. 022 Aug;179(8):573-585. [PMID: 35615814]

Hirsch J, Zhang X, Noah JA, Dravida S, Naples A, Tiede M, Wolf JM, McPartland JC. Neural correlates of eye contact and social function in autism spectrum disorder. PLoS One. 2022 Nov 9;17(11):e0265798. [PMID: 36350848]

Lee JK, Andrews DS, Ozturk A, Solomon M, Rogers S, Amaral DG, Nordahl CW. Altered Development of Amygdala-Connected Brain Regions in Males and Females with Autism. J Neurosci. 2022 Aug 3;42(31):6145-6155. [PMID: 35760533]

Lyons-Warren AM, Wangler MF, Wan YW. Cluster Analysis of Short Sensory Profile Data Reveals Sensory-Based Subgroups in Autism Spectrum Disorder. Int J Mol Sci. 2022 Oct 27;23(21):13030. [PMID: 36361815]

Mayor Torres JM, Clarkson T, Hauschild KM, Luhmann CC, Lerner MD, Riccardi G. Facial Emotions Are Accurately Encoded in the Neural Signal of Those With Autism Spectrum Disorder: A Deep Learning Approach. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Jul;7(7):688-695. [PMID: 33862256]

Niarchou M, Singer EV, Straub P, Malow BA, Davis LK. Investigating the genetic pathways of insomnia in Autism Spectrum Disorder. Res Dev Disabil. 2022 Sep;128:104299. [PMID: 35820265]

*Northrup JB, Goodwin MS, Peura CB, Chen Q, Taylor BJ, Siegel MS, Mazefsky CA. Mapping the time course of overt emotion dysregulation, self-injurious behavior, and aggression in psychiatrically hospitalized autistic youth: A naturalistic study. Autism Res. 2022 Oct;15(10):1855-1867. [PMID: 35751466]

Pecukonis M, Young GS, Brian J, Charman T, Chawarska K, Elsabbagh M, Iverson JM, Jeste S, Landa R, Messinger DS, Schwichtenberg AJ, Webb SJ, Zwaigenbaum L, Tager-Flusberg H. Early predictors of language skills at 3years of age vary based on diagnostic outcome: A baby siblings research consortium study. Autism Res. 2022 Jul;15(7):1324-1335. [PMID: 35652157]

*Pickles A, Wright N, Bedford R, Steiman M, Duku E, Bennett T, Georgiades S, Kerns CM, Mirenda P, Smith IM, Ungar WJ, Vaillancourt T, Waddell C, Zaidman-Zait A, Zwaigenbaum L, Szatmari P, Elsabbagh M. Pathways in ASD Study Team. Predictors of language regression and its association with subsequent communication development in children with autism. J Child Psychol Psychiatry. 2022 Nov;63(11):1243-1251. Epub 2022 Jan 30. [PMID: 35098539]

Safar K, Vandewouw MM, Pang EW, de Villa K, Crosbie J, Schachar R, Iaboni A, Georgiades S, Nicolson R, Kelley E, Ayub M, Lerch JP, Anagnostou E, Taylor MJ. Shared and Distinct Patterns of Functional Connectivity to Emotional Faces in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder Children. Front Psychol. 2022 Mar 9;13:826527. [PMID: 35356352]

Shen MD, Swanson MR, Wolff JJ, Elison JT, Girault JB, Kim SH, Smith RG, Graves MM, Weisenfeld LAH, Flake L, MacIntyre L, Gross JL, Burrows CA, Fonov VS, Collins DL, Evans AC, Gerig G, McKinstry RC, Pandey J, St John T, Zwaigenbaum L, Estes AM, Dager SR, Schultz RT, Styner MA, Botteron KN, Hazlett HC, Piven J; IBIS Network. Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy. Am J Psychiatry. 2022 Aug;179(8):562-572. [PMID: 35331012]

Supekar K, de Los Angeles C, Ryali S, Cao K, Ma T, Menon V. Deep learning identifies robust gender differences in functional brain organization and their dissociable links to clinical symptoms in autism. Br J Psychiatry. 2022 Feb 15:1-8. Epub ahead of print. [PMID: 35164888]

Supekar K, Ryali S, Yuan R, Kumar D, de Los Angeles C, Menon V. Robust, Generalizable, and Interpretable Artificial Intelligence-Derived Brain Fingerprints of Autism and Social Communication Symptom Severity. Biol Psychiatry. 2022 Oct 15;92(8):643-653. Epub 2022 Feb 16. [PMID: 35382930]

Xiao Y, Wen TH, Kupis L, Eyler LT, Goel D, Vaux K, Lombardo MV, Lewis NE, Pierce K, Courchesne E. Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD. Nat Hum Behav. 2022 Mar;6(3):443-454. [PMID: 34980898]

Wiggins LD, Nadler C, Hepburn S, Rosenberg S, Reynolds A, Zubler J. Toileting Resistance Among Preschool-Age Children with and Without Autism Spectrum Disorder. J Dev Behav Pediatr. 2022 May 1;43(4):216-223. [PMID: 35170572]

Genetic and Environmental Factors

Antaki D, Guevara J, Maihofer AX, Klein M, Gujral M, Grove J, Carey CE, Hong O, Arranz MJ, Hervas A, Corsello C, Vaux KK, Muotri AR, Iakoucheva LM, Courchesne E, Pierce K, Gleeson JG, Robinson EB, Nievergelt CM, Sebat J. A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex. Nat Genet. 2022 Sep;54(9):1284-1292. [PMID: 35654974]

*Havdahl A, Wootton RE, Leppert B, Riglin L, Ask H, Tesli M, Bugge Askeland R, Hannigan LJ, Corfield E, Øyen AS, Andreassen OA, Tilling K, Davey Smith G, Thapar A, Reichborn-Kjennerud T, Stergiakouli E. Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa).. JAMA Psychiatry. 2022 Aug 1;79(8):799-810. [PMID: 35793100]

Hertz-Picciotto I, Korrick SA, Ladd-Acosta C, Karagas MR, Lyall K, Schmidt RJ, Dunlop AL, Croen LA, Dabelea D, Daniels JL, Duarte CS, Fallin MD, Karr CJ, Lester B, Leve LD, Li Y, McGrath M, Ning X, Oken E, Sagiv SK, Sathyanaraya S, Tylavsky F, Volk HE, Wakschlag LS, Zhang M, O'Shea TM, Musci RJ; program collaborators for Environmental influences on Child Health Outcomes (ECHO). Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts. Autism Res. 2022 Mar;15(3):551-569. [PMID: 35199959]

Hessami K, Norooznezhad AH, Monteiro S, Barrozo ER, Abdolmaleki AS, Arian SE, Zargarzadeh N, Shekerdemian LS, Aagaard KM, Shamshirsaz AA. COVID-19 Pandemic and Infant Neurodevelopmental Impairment: A Systematic Review and Meta-analysis.. JAMA Netw Open. 2022 Oct 3;5(10):e2238941. [PMID: 36306133]

Lyall K, Ning X, Aschner JL, Avalos LA, Bennett DH, Bilder DA, Bush NR, Carroll KN, Chu SH, Croen LA, Dabelea D, Daniels JL, Duarte C, Elliott AJ, Fallin MD, Ferrara A, Hertz-Picciotto I, Hipwell AE, Jensen ET, Johnson SL, Joseph RM, Karagas M, Kelly RS, Lester BM, Margolis A, McEvoy CT, Messinger D, Neiderhiser JM, O'Connor TG, Oken E, Sathyanarayana S, Schmidt RJ, Sheinkopf SJ, Talge NM, Turi KN, Wright RJ, Zhao Q, Newschaffer C, Volk HE, Ladd-Acosta C, Environmental Influences On Child Health Outcomes OBOPCF. Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO. Am J Epidemiol. 2022 Jul 23;191(8):1407-1419. [PMID: 35362025]

Mattheisen M, Grove J, Als TD, Martin J, Voloudakis G, Meier S, Demontis D, Bendl J, Walters R, Carey CE, Rosengren A, Strom NI, Hauberg ME, Zeng B, Hoffman G, Zhang W, Bybjerg-Grauholm J, Bækvad-Hansen M, Agerbo E, Cormand B, Nordentoft M, Werge T, Mors O, Hougaard DM, Buxbaum JD, Faraone SV, Franke B, Dalsgaard S, Mortensen PB, Robinson EB, Roussos P, Neale BM, Daly MJ, Børglum AD. Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. Nat Genet. 2022 Oct;54(10):1470-1478. Epub 2022 Sep 26. [PMID: 36163277]

Suarez EA, Bateman BT, Hernández-Díaz S, Straub L, Wisner KL, Gray KJ, Pennell PB, Lester B, McDougle CJ, Zhu Y, Mogun H, Huybrechts KF. Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children. JAMA Intern Med. 2022 Oct 3;182(11):1149–60. [PMID: 36190722]

Schendel D, Munk Laursen T, Albiñana C, Vilhjalmsson B, Ladd-Acosta C, Fallin MD, Benke K, Lee B, Grove J, Kalkbrenner A, Ejlskov L, Hougaard D, Bybjerg-Grauholm J, Baekvad-Hansen M, Børglum AD, Werge T, Nordentoft M, Mortensen PB, Agerbo E. Evaluating the interrelations between the autism polygenic score and psychiatric family history in risk for autism. Autism Res. 2022 Jan;15(1):171-182. [PMID: 34664785]

Trost B, Thiruvahindrapuram B, Chan AJS, Engchuan W, Higginbotham EJ, Howe JL, Loureiro LO, Reuter MS, Roshandel D, Whitney J, Zarrei M, Bookman M, Somerville C, Shaath R, Abdi M, Aliyev E, Patel RV, Nalpathamkalam T, Pellecchia G, Hamdan O, Kaur G, Wang Z, MacDonald JR, Wei J, Sung WWL, Lamoureux S, Hoang N, Selvanayagam T, Deflaux N, Geng M, Ghaffari S, Bates J, Young EJ, Ding Q, Shum C, D'Abate L, Bradley CA, Rutherford A, Aguda V, Apresto B, Chen N, Desai S, Du X, Fong MLY, Pullenayegum S, Samler K, Wang T, Ho K, Paton T, Pereira SL, Herbrick JA, Wintle RF, Fuerth J, Noppornpitak J, Ward H, Magee P, Al Baz A, Kajendirarajah U, Kapadia S, Vlasblom J, Valluri M, Green J, Seifer V, Quirbach M, Rennie O, Kelley E, Masjedi N, Lord C, Szego MJ, Zawati MH, Lang M, Strug LJ, Marshall CR, Costain G, Calli K, Iaboni A, Yusuf A, Ambrozewicz P, Gallagher L, Amaral DG, Brian J, Elsabbagh M, Georgiades S, Messinger DS, Ozonoff S, Sebat J, Sjaarda C, Smith IM, Szatmari P, Zwaigenbaum L, Kushki A, Frazier TW, Vorstman JAS, Fakhro KA, Fernandez BA, Lewis MES, Weksberg R, Fiume M, Yuen RKC, Anagnostou E, Sondheimer N, Glazer D, Hartley DM, Scherer SW. Genomic architecture of autism from comprehensive whole-genome sequence annotation. Cell. 2022 Nov 10;185(23):4409-4427.e18. [PMID: 36368308]

Wang Y, Guo X, Hong X, Wang G, Pearson C, Zuckerman B, Clark AG, O'Brien KO, Wang X, Gu Z. Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism. Nat Commun. 2022 Jul 1;13(1):3790. [PMID: 35778412]

Warrier V, Zhang X, Reed P, Havdahl A, Moore TM, Cliquet F, Leblond CS, Rolland T, Rosengren A; EU-AIMS LEAP; iPSYCH-Autism Working Group; Spectrum 10K and APEX Consortia; Rowitch DH, Hurles ME, Geschwind DH, Børglum AD, Robinson EB, Grove J, Martin HC, Bourgeron T, Baron-Cohen S. Genetic correlates of phenotypic heterogeneity in autism. Nat Genet. 2022 Sep;54(9):1293-1304. [PMID: 35654973]

Wigdor EM, Weiner DJ, Grove J, Fu JM, Thompson WK, Carey CE, Baya N, van der Merwe C, Walters RK, Satterstrom FK, Palmer DS, Rosengren A, Bybjerg-Grauholm J, Hougaard DM, Mortensen PB, Daly MJ, Talkowski ME, Sanders SJ, Bishop SL, Børglum AD, Robinson EB. The female protective effect against autism spectrum disorder. Cell Genomics. 2022; Volume 2, Issue 6. [https://doi.org/10.1016/j.xgen.2022.100134]

Zhou X, Feliciano P, Shu C, Wang T, Astrovskaya I, Hall JB, Obiajulu JU, Wright JR, Murali SC, Xu SX, Brueggeman L, Thomas TR, Marchenko O, Fleisch C, Barns SD, Snyder LG, Han B, Chang TS, Turner TN, Harvey WT, Nishida A, O'Roak BJ, Geschwind DH; SPARK Consortium; Michaelson JJ, Volfovsky N, Eichler EE, Shen Y, Chung WK. Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes. Nat Genet. 2022 Sep;54(9):1305-1319. [PMID: 35982159]

Interventions

Benevides TW, Tao S, Becker A, Verstreate K, Shea L. Occupational Therapy Service Delivery Among Medicaid-Enrolled Children and Adults on the Autism Spectrum and With Other Intellectual Disabilities. Am J Occup Ther. 2022 Jan 1;76(1):7601180100. [PMID: 35030249]

Brian J, Solish A, Dowds E, Roth I, Bernardi K, Perry K, Daoud S, Jilderda S, MacWilliam S, Smith IM, Zwaigenbaum L, Bryson S. "Going Mobile"-increasing the reach of parent-mediated intervention for toddlers with ASD via group-based and virtual delivery. J Autism Dev Disord. 2022 Dec;52(12):5207-5220. [PMID: 35608785]

Hume K, Odom SL, Steinbrenner JR, Smith DaWalt L, Hall LJ, Kraemer B, Tomaszewski B, Brum C, Szidon K, Bolt DM. Efficacy of a School-Based Comprehensive Intervention Program for Adolescents With Autism. Exceptional Children. 2022. 88(2), 223–240. [https://doi.org/10.1177/00144029211062589]

Li C, Haegele JA, Sun F, Alves MLT, Ang SHC, Lee J, Ng K, Dos Santos Alves I, Healy S, Huang WY, Rintala P, Tan JSY, Wu Y, Yang H, Kärnä E, Maeng H, Schliemann AL, Ding D. Meeting the 24-h movement guidelines and health-related outcomes among youth with autism spectrum disorder: a seven-country observational study. Child Adolesc Psychiatry Ment Health. 2022 Jun 23;16(1):50. [PMID: 35739543]

*Panganiban J, Kasari C. Super responders: Predicting language gains from JASPER among limited language children with autism spectrum disorder. Autism Res. 2022 Aug;15(8):1565-1575. [PMID: 35437928]

Shurtz L, Schwartz C, DiStefano C, McPartland JC, Levin AR, Dawson G, Kleinhans NM, Faja S, Webb SJ, Shic F, Naples AJ, Seow H, Bernier RA, Chawarska K, Sugar CA, Dziura J, Senturk D, Santhosh M, Jeste SS. Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials. Autism. 2022 Sep 9:13623613221121425. [PMID: 36086805]

Steinbrenner JR, McIntyre N, Rentschler LF, Pearson JN, Luelmo P, Jaramillo ME, Boyd BA, Wong C, Nowell SW, Odom SL, Hume KA. Patterns in reporting and participant inclusion related to race and ethnicity in autism intervention literature: Data from a large-scale systematic review of evidence-based practices. Autism. 2022 Nov;26(8):2026-2040. [PMID: 35068190]

Services and Supports

Davies J, Heasman B, Livesey A, Walker A, Pellicano E, Remington A. Autistic adults' views and experiences of requesting and receiving workplace adjustments in the UK. PLoS One. Aug 5;17(8):e0272420. [PMID: 35930548]

Eapen V, Islam R, Azim SI, Masi A, Klein L, Karlov L. Factors Impacting Parental Quality of Life in Preschool Children on the Autism Spectrum. J Autism Dev Disord. 2022 Dec 20. [PMID: 36538128]

Kaiser K, Villalobos ME, Locke J, Iruka IU, Proctor C, Boyd B. A culturally grounded autism parent training program with Black parents. Autism.. 2022 Apr;26(3):716-726. [PMID: 35232271]

Lerner MD, Brown CE, Sridhar A, Tschida JE, Felsman P, Libsack EJ, Kerns CM, Moskowitz LJ, Soorya L, Wainer A, Cohn E, Drahota A. Usual care for youth with autism spectrum disorder: Community-based providers' reported familiarity with treatment practices. Front Psychiatry. 2022 Jul 26;13:923025. [PMID: 35958649]

*Shenouda J, Barrett E, Davidow AL, Sidwell K, Halperin W, Silenzio VMB, Zahorodny W. Disparities in Early Intervention Program Participation by Children With Autism Spectrum Disorder in a US Metropolitan Area, 2006 to 2016. JAMA Pediatr. 2022 Sep 1;176(9):906-914. [PMID: 35849409]

Sridhar A, Kuhn J, Faja S, Sabatos-DeVito M, Nikolaeva JI, Dawson G, Nelson CA, Webb SJ, Bernier R, Jeste S, Chawarska K, Sugar CA, Shic F, Naples A, Dziura J, McPartland JC; ABC-CT Consortium. Patterns of Intervention Utilization Among School-Aged Children with Autism Spectrum Disorder: Findings from a Multi-Site Research Consortium. Res Autism Spectr Disord. 2022 Jun;94:101950. [PMID: 35444715]

*Stadnick NA, Martinez K, Coleman KJ, Gizzo DP, Lane E, Lee N, Kuelbs CL, Aarons GA, Brookman-Frazee L. Mental health screening in pediatric primary care for children with autism. Autism.. 022 Jul;26(5):1305-1311. [PMID: 35105226]

Stockham NT, Paskov KM, Tabatabaei K, Sutaria S, Liu B, Kent J, Wall DP. An Informatics Analysis to Identify Sex Disparities and Healthcare Needs for Autism across the United States. AMIA Annu Symp Proc. 2022 May 23;2022:456-465. [PMID: 35854759]

Yousefvand S, Dadgar H, Mohammadi MR, Maroufizadeh S, Yousefvand S. Broader Autism Phenotype and Communication Skills in Parents of Children with Autism. jmr. 2022;16(4):338-346. [https://doi.org/10.18502/jmr.v16i4.10761]

Lifespan

Al-Beltagi M, Saeed NK, Bediwy AS, Alhawamdeh R, Qaraghuli S. Effects of COVID-19 on children with autism. World J Virol. 2022 Nov 25;11(6):411-425. [PMID: 36483100]

Bury SM, Jellett R, Haschek A, Wenzel M, Hedley D, Spoor JR. Understanding language preference: Autism knowledge, experience of stigma and autism identity. Autism. 2022 Dec 13:13623613221142383. [PMID: 36510834]

Cope R, Remington A. The Strengths and Abilities of Autistic People in the Workplace. Autism Adulthood. 2022 Mar 1;4(1):22-31. [PMID: 36605563]

*Doherty M, Neilson S, O'Sullivan J, Carravallah L, Johnson M, Cullen W, Shaw SCK. Barriers to healthcare and self-reported adverse outcomes for autistic adults: a cross-sectional study. BMJ Open. 2022 Feb 22;12(2):e056904. [PMID: 35193921]

*Forbes G, Kent R, Charman T, Baird G, Pickles A, Simonoff E. How do autistic people fare in adult life and can we predict it from childhood? Autism Res. 2022 Dec 15. [PMID: 36519265]

Friedman C. Moving home: Community transition supports for people with intellectual and developmental disabilities. Disabil Health J.. 2022 Nov 26:101419. [PMID: 36528523]

Goldfarb Y, Gal E, Golan O. Implications of Employment Changes Caused by COVID-19 on Mental Health and Work-Related Psychological Need Satisfaction of Autistic Employees: A Mixed-Methods Longitudinal Study. J Autism Dev Disord. 2022 Jan;52(1):89-102. [PMID: 33635422]

Groenman AP, Torenvliet C, Radhoe TA, Agelink van Rentergem JA, Geurts HM. Menstruation and menopause in autistic adults: Periods of importance? Autism. 2022 Aug;26(6):1563-1572. [PMID: 34825585]

Harmens M, Sedgewick F, Hobson H. Autistic women's diagnostic experiences: Interactions with identity and impacts on well-being. Womens Health (Lond). 2022 Jan-Dec;18:17455057221137477. [PMID: 36377396]

Hendriks O, Wei Y, Warrier V, Richards G. Autistic Traits, Empathizing-Systemizing, and Gender Diversity. Arch Sex Behav. 2022 May;51(4):2077-2089. [PMID: 35467170]

Huang Y, Hwang YIJ, Arnold SRC, Lawson LP, Richdale AL, Trollor JN. Autistic Adults' Experiences of Diagnosis Disclosure. J Autism Dev Disord. 2022 Dec;52(12):5301-5307. [PMID: 34978025]

*Jadav N, Bal VH. Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research. Autism Res. 2022 Nov;15(11):2112-2125. [PMID: 36054777]

Kim SA, Baczewski L, Pizzano M, Kasari C, Sturm A. Discrimination and Harassment Experiences of Autistic College Students and Their Neurotypical Peers: Risk and Protective Factors. J Autism Dev Disord. 2022 Sep 14. [PMID: 36103077]

*Lee NR, McQuaid GA, Grosman HE, Jayaram S, Wallace GL. Vocational Outcomes in ASD: An Examination of Work Readiness Skills as well as Barriers and Facilitators to Employment Identified by Autistic Adults. J Autism Dev Disord. 2022 Nov 17:1–14. [PMID: 36394783]

Martin V, Flanagan TD, Vogus TJ, Chênevert D. Sustainable employment depends on quality relationships between supervisors and their employees on the autism spectrum. Disabil Rehabil. 2022 May 16:1-12. [PMID: 35576174]

Martini MI, Kuja-Halkola R, Butwicka A, Du Rietz E, D'Onofrio BM, Happé F, Kanina A, Larsson H, Lundström S, Martin J, Rosenqvist MA, Lichtenstein P, Taylor MJ. Sex Differences in Mental Health Problems and Psychiatric Hospitalization in Autistic Young Adults. JAMA Psychiatry. 2022 Dec 1;79(12):1188-1198. [PMID: 36287538]

Must A, Eliasziw M, Bowling A, Magaña S, Stanish H, Bandini L, Curtin C, Kral TVE. Relationship between Childhood Obesity and Autism Spectrum Disorder Varies by Child's Age and Parents' Weight Status in a Sample of Sibling Dyads. Child Obes. 2023 Jul;19(5):309-315. Epub 2022 Aug 22. [PMID: 35994016]

Petty S, Tunstall L, Richardson H, Eccles N. Workplace Adjustments for Autistic Employees: What is 'Reasonable'? J Autism Dev Disord. 2023 Jan;53(1):236-244. Epub 2022 Jan 12. [PMID: 35020116]

Rothman EF, Graham Holmes L, Caplan R, Chiang M, Haberer B, Gallop N, Kadel R, Person M, Sanchez A, Quinn E, Wharmby P. Healthy Relationships on the Autism Spectrum (HEARTS): A feasibility test of an online class co-designed and co-taught with autistic people. Autism.. 2022 Apr;26(3):690-702. [PMID: 35000417]

*Schott W, Tao S, Shea L. Co-occurring conditions and racial-ethnic disparities: Medicaid enrolled adults on the autism spectrum. Autism Res. 2022 Jan;15(1):70-85. [PMID: 34854249]

*Shea L, Tao S, Marcus SC, Mandell D, Epstein AJ. Medicaid Disruption Among Transition-Age Youth on the Autism Spectrum. Med Care Res Rev. 2022 Aug;79(4):525-534. [PMID: 34632834]

Stratton E, Glozier N, Woolard A, Gibbs V, Demetriou EA, Boulton KA, Hickie I, Pellicano E, Guastella AJ. Understanding the vocational functioning of autistic employees: the role of disability and mental health. Disabil Rehabil. 2023 May;45(9):1508-1516. Epub 2022 May 4. [PMID: 35508414]

Taylor SC, Gehringer BN, Dow HC, Langer A, Rawot E, Smernoff Z, Steeman S, Almasy L, Rader DJ, Bučan M, Brodkin ES. Contrasting Views of Autism Spectrum Traits in Adults, Especially in Self-Reports vs Informant-Reports for Women High in Autism Spectrum Traits. J Autism Dev Disord. 2022 Dec 9:1–13. [PMID: 36484966]

Whelpley CE, May CP. Seeing is Disliking: Evidence of Bias Against Individuals with Autism Spectrum Disorder in Traditional Job Interviews. J Autism Dev Disord. 2023 Apr;53(4):1363-1374. Epub 2022 Mar 16. [PMID: 35294714]

Infrastructure and Prevalence

Catalá-López F, Hutton B, Page MJ, Driver JA, Ridao M, Alonso-Arroyo A, Valencia A, Macías Saint-Gerons D, Tabarés-Seisdedos R. Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/ Hyperactivity Disorder: A Systematic Review and Meta-analysis. JAMA Pediatr. 2022 Apr 1;176(4):e216401. [PMID: 35157020]

D'Mello AM, Frosch IR, Li CE, Cardinaux AL, Gabrieli JDE. Exclusion of females in autism research: Empirical evidence for a "leaky" recruitment-to-research pipeline. Autism Res. 2022 Oct;15(10):1929-1940. [PMID: 36054081]

Etyemez S, Esler A, Kini A, Tsai PC, DiRienzo M, Maenner M, Lee LC. The role of intellectual disability with autism spectrum disorder and the documented cooccurring conditions: A population-based study. Autism Res. 2022 Dec;15(12):2399-2408. [PMID: 36245337]

Heyl J, Hardy F, Tucker K, Hopper A, Marchã MJ, Liew A, Reep J, Harwood KA, Roberts L, Yates J, Day J, Wheeler A, Eve-Jones S, Briggs TWR, Gray WK. Data quality and autism: Issues and potential impacts. Int J Med Inform. 2022 Nov 28;170:104938. [PMID: 36455477]

*Shaw KA, McArthur D, Hughes MM, Bakian AV, Lee LC, Pettygrove S, Maenner MJ. Progress and Disparities in Early Identification of Autism Spectrum Disorder: Autism and Developmental Disabilities Monitoring Network, 2002-2016. J Am Acad Child Adolesc Psychiatry. 2022 Jul;61(7):905-914. [PMID: 34838692]

Varcin KJ, Herniman SE, Lin A, Chen Y, Perry Y, Pugh C, Chisholm K, Whitehouse AJO, Wood SJ. Occurrence of psychosis and bipolar disorder in adults with autism: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2022 Mar;134:104543. [PMID: 35063494]

Zubler JM, Wiggins LD, Macias MM, Whitaker TM, Shaw JS, Squires JK, Pajek JA, Wolf RB, Slaughter KS, Broughton AS, Gerndt KL, Mlodoch BJ, Lipkin PH. Evidence-Informed Milestones for Developmental Surveillance Tools. Pediatrics. 2022 Mar 1;149(3):e2021052138. [PMID: 35132439]

About the IACC

The Interagency Autism Coordinating Committee (IACC) is a federal advisory committee charged with coordinating federal activities concerning autism spectrum disorder (ASD) and providing advice to the Secretary of Health and Human Services (HHS) on issues related to autism. The Committee was established by Congress under the Children's Health Act of 2000, reconstituted under the Combating Autism Act of 2006, and renewed most recently under the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2019.

Membership of the Committee includes a wide array of federal agencies involved in autism research and services, as well as public stakeholders, including autistic adults, family members of those on the autism spectrum, advocates, service providers, and researchers, who represent a variety of perspectives. The IACC membership is composed to ensure that the Committee is equipped to address the broad range of issues and challenges experienced by individuals and families in the autism community.

Under past and present authorizing legislation, the IACC was and is currently required to (1) develop and annually update a strategic plan for autism research, (2) develop and annually update a summary of advances in autism research, and (3) monitor federal activities related to autism.

Through these and other activities, the IACC provides guidance to HHS and partners with other federal departments, research and advocacy organizations, and the broader autism community to accelerate research and enhance services with the goal of positively impacting the lives of people on the autism spectrum and their families.

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For more information about the IACC, see https://iacc.hhs.gov.

Interagency Autism Coordinating Committee Member Roster

Chair

Federal Members

Public Members

Office of National Autism Coordination Staff

*Also a staff member of the Office of Autism Research Coordination (OARC), within the Office of National Autism Coordination (ONAC)

Cover Design
NIH Medical Arts Branch

Copyright Information
All material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.

Suggested Citation
Interagency Autism Coordinating Committee (IACC). 2022 IACC Summary of Advances in Autism Research. December 2023. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: https://iacc.hhs.gov/publications/summary-of-advances/2022/.