In 2009, the Interagency Autism Coordinating Committee (IACC) conducted a comprehensive analysis of the autism spectrum disorder (ASD) research portfolios of major Federal agencies and private organizations. The analysis was conducted to better inform the committee and interested public about the funding landscape for ASD research and how well this matched the new IACC Strategic Plan for ASD research. In so doing, the portfolio analysis also can be used by Federal agencies and private research organizations to help guide future funding priorities by highlighting current gaps and opportunities in ASD research as well as serving as a baseline to assess research progress.