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Summary of Advances Cover 2013
Summary of Advance
In Autism Spectrum Disorder Research
2013
Appendices

Citation List – Articles Selected for the 2012 Summary of Advances

Question 1: When Should I Be Concerned?

Guevara JP, Gerdes M, Localio R, Huang YV, Pinto-Martin J, Minkovitz CS, Hsu D, Kyriakou L, Baglivo S, Kavanagh J, Pati S. Effectiveness of developmental screening in an urban setting. Pediatrics. 2013 Jan;131(1):30–37. [PMID: 23248223]

Jones W, Klin A. Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism. Nature. 2013 Dec 19;504(7480):427-31. [PMID: 24196715]

Landa RJ, Gross AL, Stuart EA, Faherty A. Developmental trajectories in children with and without autism spectrum disorders: the first 3 years. Child Dev. 2013 Mar-Apr;84(2):429–442. [PMID: 23110514]

Zuckerman KE, Mattox K, Donelan K, Batbayar O, Baghaee A, Bethell C. Pediatrician identification of Latino children at risk for autism spectrum disorder. Pediatrics. 2013 Sep;132(3):445–453. [PMID: 23958770]

Question 2: How Can I Understand What Is Happening?

Chaidez V, Hansen RL, Hertz-Picciotto I. Gastrointestinal problems in children with autism, developmental delays or typical Development. J Autism Dev Disord. 2013 Nov. [Epub ahead of print] [PMID: 24193577]

Doshi-Velez F, Ge Y, Kohane I. Comorbidity clusters in autism spectrum disorders: an electronic health record time-series analysis. Pediatrics. 2014 Jan;133(1):e54-63. [PMID: 24323995]

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013 Dec 19;155(7):1451-63. [PMID: 24315484]

Willsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K,Devlin B, Sestan N, State MW. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell. 2013 Nov 21;155(5):997-1007. [PMID: 24267886]

Parikshak NN, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell. 2013 Nov 21;155(5):1008-21. [PMID: 24267887]

Question 3: What Caused This to Happen and Can It Be Prevented?

Bauman MD, Iosif AM, Ashwood P, Braunschweig D, Lee A, Schumann CM, Van de Water J, Amaral DG. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl Psychiatry. 2013 Jul 9;3:e278. [PMID: 23838889]

Frans EM, Sandin S, Reichenberg A, Långström N, Lichtenstein P, McGrath JJ, Hultman CM. Autism risk across generations: a population-based study of advancing grandpaternal and paternal age. JAMA Psychiatry. 2013 May;70(5):516-21. [PMID: 23553111]

Surén P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D, Lie KK, Lipkin WI, Magnus P, Reichborn-Kjennerud T, Schjølberg S, Davey Smith G, Øyen AS, Susser E, Stoltenberg C. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA. 2013 Feb 13;309(6):570-7. [PMID: 23403681]

Question 4: Which Treatments and Interventions Will Help?

Goods KS, Ishijima E, Chang Y-C, Kasari C. Preschool based JASPER intervention in minimally verbal children with autism: pilot RCT. J Autism Dev Disord. 2013 May;43(5):1050–1056. [PMID: 22965298]

Gordon I, Vander Wyk BC, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proc Natl Acad Sci 2013 Dec;110(52):20953–20958. [PMID: 24297883]

Question 5: Where Can I Turn for Services?

Boyd BA, Hume K, McBee MT, Alessandri M, Gutierrez A, Johnson L, Sperry L, Odom SL. Comparative efficacy of LEAP, TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders. J Autism Dev Disord. 2014 Feb;44(2):366–380. [PMID: 23812661]

Nahmias AS, Kase C, Mandell DS. Comparing cognitive outcomes among children with autism spectrum disorders receiving community-based early intervention in one of three placements. Autism Int J Res Pract. 2014 Apr;18(3):311-320. [PMID: 23188885]

Question 6: What Does the Future Hold, Particularly for Adults?

Fein D, Barton M, Eigsti I-M, Kelley E, Naigles L, Schultz RT, Stevens M, Helt M, Orinstein A, Rosenthal M, Troyb E, Tyson K. Optimal outcome in individuals with a history of autism. J Child Psychol Psychiatry. 2013 Feb;54(2):195–205. [PMID: 23320807]

Mavranezouli I, Megnin-Viggars O, Cheema N, Howlin P, Baron-Cohen S, Pilling S. The cost-effectiveness of supported employment for adults with autism in the United Kingdom. Autism Int J Res Pract. 2013 Oct. [Epub ahead of print] [PMID: 24126866]

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Hewitt A, Gulaid A, Hamre K, Esler A, Punyko J, Reichle J, Reiff M. Minneapolis Somali autism spectrum disorder prevalence project: Community report 2013. (PDF – 2 MB) 2013 December.

Rice CE, Rosanoff M, Dawson G, Durkin MS, PhD, Croen LA, PhD, Singer A, Yeargin-Allsopp M. Evaluating changes in the prevalence of the autism spectrum disorders (ASDs). Public Health Reviews. 2013 March;34(6);2.

Full Listing of Nominated Articles

Question 1: When Should I Be Concerned?

Barnevik Olsson M, Carlsson LH, Westerlund J, Gillberg C, Fernell E. Autism before diagnosis: crying, feeding and sleeping problems in the first two years of life. Acta Paediatr. 2013 Jun;102(6):635-9. [PMID: 23480473]

Clifford SM, Hudry K, Elsabbagh M, Charman T, Johnson MH and BASIS Team. Temperament in the first 2 years of life in infants at high-risk for autism spectrum disorders. J Autism Dev Disord. 2013 Mar;43(3):673–686. [PMID: 22918859]

Daniels AM, Mandell DS. Children's compliance with American Academy of Pediatrics' well-child care visit guidelines and the early detection of autism. J Autism Dev Disord. 2013 Dec;43(12):2844-54. [PMID: 23619952]

Elison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H, Botteron KN, Dager SR, Estes AM, Evans AC, Gerig G, Hazlett HC, Schultz RT, Styner M, Zwaigenbaum L, Piven J; IBIS Network. White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism. Am J Psychiatry. 2013 Aug1;170(8):899-908. [PMID: 23511344]

Garon N, Smith IM, Bryson SE. A novel executive function battery for preschoolers: Sensitivity to age differences. Child Neuropsychol. 2013 Dec. [Epub ahead of print] [PMID: 24295496]

Selected Article
Guevara JP, Gerdes M, Localio R, Huang YV, Pinto-Martin J, Minkovitz CS, Hsu D, Kyriakou L, Baglivo S, Kavanagh J, Pati S. Effectiveness of developmental screening in an urban setting. Pediatrics. 2013 Jan;131(1):30–37. [PMID: 23248223]

Selected Article
Jones W, Klin A. Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism. Nature. 2013 Dec 19;504(7480):427-31. [PMID: 24196715]

Selected Article
Landa RJ, Gross AL, Stuart EA, Faherty A. Developmental trajectories in children with and without autism spectrum disorders: the first 3 years. Child Dev. 2013 Mar-Apr;84(2):429–442. [PMID: 23110514]

Lloyd-Fox S, Blasi A, Elwell CE, Charman T, Murphy D, Johnson MH. Reduced neural sensitivity to social stimuli in infants at risk for autism. Proc Biol Sci. 2013 Mar 13;280(1758):20123026. [PMID: 23486434]

Nickel LR, Thatcher AR, Keller F, Wozniak RH, Iverson JM. Posture development in infants at heightened vs. low risk for autism spectrum disorders. Infancy. 2013 Sep;18(5):639-661. [PMID: 24027437]

Taylor B, Jick H, Maclaughlin D. Prevalence and incidence rates of autism in the UK: time trend from 2004-2010 in children aged 8 years. BMJ Open. 2013 Oct;3(10):e003219. [PMID: 24131525]

Selected Article
Zuckerman KE, Mattox K, Donelan K, Batbayar O, Baghaee A, Bethell C. Pediatrician identification of Latino children at risk for autism spectrum disorder. Pediatrics. 2013 Sep;132(3):445–453. [PMID: 23958770]

Question 2: How Can I Understand What Is Happening?

Bauman MD, Iosif A-M, Smith SEP, Bregere C, Amaral DG, Patterson PH. Activation of the maternal immune system during pregnancy alters behavioral development of Rhesus monkey offspring. Biol Psychiatry. 2014 Feb;75(4):332–341. [PMID: 24011823]

Bouvet L, Mottron L, Valdois S, Donnadieu S. Auditory stream segregation in autism spectrum disorder: benefits and downsides of superior perceptual processes. J Autism Dev Disord. 2013 Nov. [Epub ahead of print] [PMID: 24281422]

Braunschweig D, Krakowiak P, Duncanson P, Boyce R, Hansen RL, Ashwood P, Hertz-Picciotto I, Pessah IN, Van de Water J. Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Transl Psychiatry. 2013 Jul 9;3:e277. [PMID: 23838888]

Brimberg L, Sadiq A, Gregersen PK, Diamond B. Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Mol Psychiatry. 2013 Nov;18(11):1171-7. [PMID: 23958959]

Brown AS, Sourander A, Hinkka-Yli-Salomäki S, McKeague IW, Sundvall J, Surcel H-M. Elevated maternal C-reactive protein and autism in a national birth cohort. Mol Psychiatry. 2014 Feb;19(2):259–264. [PMID: 23337946]

Selected Article
Chaidez V, Hansen RL, Hertz-Picciotto I. Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord. 2013 Nov. [Epub ahead of print] [PMID: 24193577]

Chanda S, Marro S, Wernig M, Sudhof TC. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci 2013 Sep;110(41):16622–16627. [PMID: 24046374]

Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K. Structural and molecular interrogation of intact biological systems. Nature. 2013 May 16;497(7449):332-7. [PMID: 23575631]

Selected Article
Doshi-Velez F, Ge Y, Kohane I. Comorbidity clusters in autism spectrum disorders: an electronic health record time-series analysis. Pediatrics. 2014 Jan;133(1):e54-63. [PMID: 24323995]

Ecker C, Ginestet C, Feng Y, Johnston P, Lombardo MV, Lai M-C, Suckling J, Palaniyappan L, Daly E, Murphy CM, Williams SC, Bullmore ET, Baron-Cohen S, Brammer M, Murphy DGM, MRC AIMS Consortium. Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness, and autistic symptoms. JAMA Psychiatry. 2013 Jan;70(1):59–70. [PMID: 23404046]

Frye RE, Delatorre R, Taylor H, Slattery J, Melnyk S, Chowdhury N, James SJ. Redox metabolism abnormalities in autistic children associated with mitochondrial disease. Transl Psychiatry. 2013 Jun 18;3:e273. [PMID: 23778583]

Grove R, Baillie A, Allison C, Baron-Cohen S, Hoekstra RA. Empathizing, systemizing, and autistic traits: latent structure in individuals with autism, their parents, and general population controls. J Abnorm Psychol. 2013 May;122(2):600–609. [PMID: 23713510]

Selected Article
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013 Dec 19;155(7):1451-63. [PMID: 24315484]

James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP. Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum. Transl Psychiatry. 2013 Feb 19;3:e232. [PMID: 23423141]

King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. Topoisomerases facilitate transcription of long genes linked to autism. Nature. 2013 Sep 5;501(7465):58-62. [PMID: 23995680]

Kuhl PK, Coffey-Corina S, Padden D, Munson J, Estes A, Dawson G. Brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6. PLoS One. 2013 May 29;8(5):e64967. [PMID: 23734230]

Ladd-Acosta C, Hansen KD, Briem E, Fallin MD, Kaufmann WE, Feinberg AP. Common DNA methylation alterations in multiple brain regions in autism. Mol Psychiatry. 2013 Sep 3. [Epub ahead of print] [PMID: 23999529]

Lai M-C, Lombardo MV, Suckling J, Ruigrok ANV, Chakrabarti B, Ecker C, Deoni SCL, Craig MC, Murphy DGM, Bullmore ET, MRC AIMS Consortium, Baron-Cohen S. Biological sex affects the neurobiology of autism. Brain J Neurol. 2013 Sep;136(Pt 9):2799–2815. [PMID: 23935125]

Lau NM, Green PH, Taylor AK, Hellberg D, Ajamian M, Tan CZ, Kosofsky BE, Higgins JJ, Rajadhyaksha AM, Alaedini A. Markers of Celiac Disease and Gluten Sensitivity in Children with Autism. PLoS One. 2013 Jun 18;8(6):e66155. [PMID: 23823064]

McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. Mosaic copy number variation in human neurons. Science. 2013 Nov 1;342(6158):632-7. [PMID: 24179226]

Moreno-De-Luca A, Myers SM, Challman TD, Moreno-De-Luca D, Evans DW, Ledbetter DH. Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence. Lancet Neurol. 2013 Apr;12(4):406–414. [PMID: 23518333]

Mottron L, Dawson M. The autistic spectrum. Handb Clin Neurol. 2013 111:263–271. [PMID: 23622174]

Selected Article
Parikshak NN, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell. 2013 Nov 21;155(5):1008-21. [PMID: 24267887]

Robinson EB, Lichtenstein P, Anckarsäter H, Happé F, Ronald A. Examining and interpreting the female protective effect against autistic behavior. Proc Natl Acad Sci. 2013 Mar 26;110(13):5258-62. [PMID: 23431162]

Schroeder DI, Blair JD, Lott P, Yu HOK, Hong D, Crary F, Ashwood P, Walker C, Korf I, Robinson WP, LaSalle JM. The human placenta methylome. Proc Natl Acad Sci. 2013 Apr 9;110(15):6037–6042. [PMID: 23530188]

Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE. SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature. 2013 Nov 14;503(7475):267-71. [PMID: 24132240]

Siniscalco D, Cirillo A, Bradstreet JJ, Antonucci N. Epigenetic findings in autism: new perspectives for therapy. Int J Environ Res Public Health. 2013 Sep 11;10(9):4261-73. [PMID: 24030655]

Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubash Mi, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y,Tsujii M, Sugiyama T, Mori N. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry. 2013 Jan;70(1):49-58. [PMID: 23404112]

Tavassoli T, Miller LJ, Schoen SA, Nielsen DM, Baron-Cohen S. Sensory over-responsivity in adults with autism spectrum conditions. Autism Int J Res Pract. 2013 Oct 1. [Epub ahead of print] [PMID: 24085741]

Von dem Hagen EAH, Stoyanova RS, Rowe JB, Baron-Cohen S, Calder AJ. Direct Gaze Elicits Atypical Activation of the Theory-of-Mind Network in Autism Spectrum Conditions. Cereb Cortex. 2013 Jan 16. [Epub ahead of print] [PMID: 23324559]

Selected Article
Willsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N, State MW. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell. 2013 Nov 21;155(5):997-1007. [PMID: 24267886]

Question 3: What Caused This to Happen and Can It Be Prevented?

Selected Article
Bauman MD, Iosif AM, Ashwood P, Braunschweig D, Lee A, Schumann CM, Van de Water J, Amaral DG. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl Psychiatry. 2013 Jul 9;3:e278. [PMID: 23838889]

Selected Article
Frans EM, Sandin S, Reichenberg A, Långström N, Lichtenstein P, McGrath JJ, Hultman CM. Autism risk across generations: a population-based study of advancing grandpaternal and paternal age. JAMA Psychiatry. 2013 May;70(5):516-21. [PMID: 23553111]

Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M; Simons Simplex Collection Genetics Consortium, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH Jr, Devlin B, Morrow EM. Intellectual disability is associated with increased runs of homozygosity in simplex autism. Am J Hum Genet. 2013 Jul 11;93(1):103-9. [PMID: 23830515]

Geier DA, Hooker BS, Kern JK, King PG, Sykes LK, Geier MR. A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States. Transl Neurodegener. 2013 Dec;2(1):25. [PMID: 24354891]

He X, Sanders SJ, Liu L, De Rubeis S, Lim ET, Sutcliffe JS, Schellenberg GD, Gibbs RA, Daly MJ, Buxbaum JD, State MW, Devlin B, Roeder K. Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes. PLoS Genet. 2013 Aug;9(8):e1003671. [PMID: 23966865]

Lim ET, Raychaudhuri S, Sanders SJ, Stevens C, Sabo A, MacArthur DG, Neale BM, Kirby A, Ruderfer DM, Fromer M, Lek M, Liu L, Flannick J, Ripke S, Nagaswamy U, Muzny D, Reid JG, Hawes A, Newsham I, Wu Y, Lewis L, Dinh H, Gross S, Wang LS, Lin CF, Valladares O, Gabriel SB, dePristo M, Altshuler DM, Purcell SM; NHLBI Exome Sequencing Project, State MW, Boerwinkle E, Buxbaum JD, Cook EH, Gibbs RA, Schellenberg GD, Sutcliffe JS, Devlin B, Roeder K, Daly MJ. Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron. 2013 Jan 23;77(2):235-42. [PMID: 23352160]

Noh HJ, Ponting CP, Boulding HC, Meader S, Betancur C, Buxbaum JD, Pinto D, Marshall CR, Lionel AC, Scherer SW, Webber C. Network topologies and convergent aetiologies arising from deletions and duplications observed in individuals with autism. PLoS Genet. 2013 Jun;9(6):e1003523. [PMID: 23754953]

Roberts AL, Lyall K, Hart JE, Laden F, Just AC, Bobb JF, Koenen KC, Ascherio A, Weisskopf MG. Perinatal air pollutant exposures and autism spectrum disorder in the children of nurses' health study II participants. Environ Health Perspect. 2013 Aug;121(8):978–984. [PMID: 23816781]

Sharpe MA, Gist TL, Baskin DS. B-lymphocytes from a population of children with autism spectrum disorder and their unaffected siblings exhibit hypersensitivity to thimerosal. J Toxicol. 2013 Jun;(2013):801517. [PMID: 23843785]

Selected Article
Surén P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D, Lie KK, Lipkin WI, Magnus P, Reichborn-Kjennerud T, Schjølberg S, Davey Smith G, Øyen AS, Susser E, Stoltenberg C. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA. 2013 Feb 13;309(6):570-7. [PMID: 23403681]

van Wijngaarden E, Davidson PW, Smith TH, Evans K, Yost K, Love T, Thurston SW, Watson GE, Zareba G, Burns CM, Shamlaye CF, Myers GJ. Autism spectrum disorder phenotypes and prenatal exposure to methylmercury. Epidemiology. 2013 Sep;24(5):651-9. [PMID: 23873071]

Volk HE, Kerin T, Lurmann F, Hertz-Picciotto I, McConnell R, Campbell DB. Autism Spectrum Disorder: Interaction of Air Pollution with the MET Receptor Tyrosine Kinase Gene. Epidemiology. 2014 Jan;25(1):44-7. [PMID: 24240654]

Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry. 2013 Apr;19(4):495-503. [PMID: 23608919]

Yu TW, Chahrour MH, Coulter ME, Jiralerspong S, Okamura-Ikeda K, Ataman B, Schmitz-Abe K, Harmin DA, Adli M, Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J, Nasir RH, Ware J, Joseph RM, Hill RS, Kwan BY, Al-Saffar M, Mukaddes NM, Hashmi A, Balkhy S, Gascon GG, Hisama FM, LeClair E, Poduri A, Oner O, Al-Saad S, Al-Awadi SA, Bastaki L, Ben-Omran T, Teebi AS, Al-Gazali L, Eapen V, Stevens CR, Rappaport L, Gabriel SB, Markianos K, State MW, Greenberg ME, Taniguchi H, Braverman NE, Morrow EM, Walsh CA. Using whole-exome sequencing to identify inherited causes of autism. Neuron. 2013 Jan 23;77(2):259-73. [PMID: 23352163]

Question 4: Which Treatments and Interventions Will Help?

Emerson A, Dearden J. Accommodating to motor difficulties and communication impairments in people with autism: the MORE intervention model. Front Integr Neurosci. 2013 Jun;7:45. [PMID: 23785315]

Feinberg E, Augustyn M, Fitzgerald E, Sandler J, Ferreira-Cesar Suarez Z, Chen N, Cabral H, Beardslee W, Silverstein M. Improving maternal mental health after a child's diagnosis of autism spectrum disorder: results from a randomized clinical trial. JAMA Pediatr. 2014 Jan;168(1):40–46. [PMID: 24217336]

Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ. Effectiveness of methylcobalamin and folinic acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status. Autism Res Treat. 2013 Oct; 2013:609705. [PMID: 24224089]

Selected Article
Goods KS, Ishijima E, Chang Y-C, Kasari C. Preschool based JASPER intervention in minimally verbal children with autism: pilot RCT. J Autism Dev Disord. 2013 May;43(5):1050–1056. [PMID: 22965298]

Selected Article
Gordon I, Vander Wyk BC, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proc Natl Acad Sci. 2013 Dec;110(52):20953–20958. [PMID: 24297883]

Kasari C, Brady N, Lord C, Tager-Flusberg H. Assessing the minimally verbal school-aged child with autism spectrum disorder. Autism Res. 2013 Dec;6(6):479–493. [PMID: 24353165]

Kasari C, Smith T. Interventions in schools for children with autism spectrum disorder: Methods and recommendations. Autism. 2013 Apr;17(3):254–267. [PMID: 23592848]

Lawton, K, Kasari, C. Teacher implementation of joint attention intervention in preschool classrooms: fidelity and context. Autism. 2013 Feb;3(108).

Malow BA, Adkins KW, Reynolds A, Weiss SK, Loh A, Fawkes D, Katz T, Goldman SE, Madduri N, Hundley R, Clemons T. Parent-based sleep education for children with autism spectrum disorders. J Autism Dev Disord. 2014 Jan;44(1):216–228. [PMID: 23754339]

McMahon CM, Lerner MD, Britton N. Group-based social skills interventions for adolescents with higher-functioning autism spectrum disorder: a review and looking to the future. Adolesc Health Med Ther. 2013 Jan;2013(4):23–28. [PMID: 23956616]

Perry A, Blacklock K, Dunn Geier J. The relative importance of age and IQ as predictors of outcomes in Intensive Behavioral Intervention. Res Autism Spectr Disord. 2013 Sep;7(9):1142–1150.

Ruble LA, McGrew JH, Toland MD, Dalrymple NJ, Jung LA. A randomized controlled trial of COMPASS web-based and face-to-face teacher coaching in autism. J Consult Clin Psychol. 2013 Jun;81(3):566–572. [PMID: 23438314]

Schertz HH, Odom SL, Baggett KM, Sideris JH. Effects of Joint Attention Mediated Learning for toddlers with autism spectrum disorders: An initial randomized controlled study. Early Child. Res Q. 2013 Apr;28(2):249–258.

Schreibman L, Stahmer AC. A randomized trial comparison of the effects of verbal and pictorial naturalistic communication strategies on spoken language for young children with autism. J Autism Dev Disord. 2013 Nov. [Epub ahead of print] [PMID: 24272416]

Steiner AM, Gengoux GW, Klin A, Chawarska K. Pivotal response treatment for infants at-risk for autism spectrum disorders: a pilot study. J Autism Dev Disord. 2013 Jan;43(1):91–102. [PMID: 22573001]

Tager-Flusberg H, Kasari C. Minimally verbal school-aged children with autism spectrum disorder: the neglected end of the spectrum. Autism Res. 2013 Dec;6(6):468–478. [PMID: 24124067]

Williams K, Brignell A, Randall M, Silove N, Hazell P. Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2013 Aug;8:CD004677. [PMID: 23959778]

Woo CC, Leon M. Environmental enrichment as an effective treatment for autism: a randomized controlled trial. Behav Neurosci. 2013 Aug;127(4):487–497. [PMID: 23688137]

Yasuda H, Kobayashi M, Yasuda Y, Tsutsui T. Estimation of autistic children by metallomics analysis. Sci Rep. 2013 Feb;3:1199. [PMID: 23383369]

Teng BL, Nonneman RJ, Agster KL, Nikolova VD, Davis TT, Riddick NV, Baker LK, Pedersen CA, Jarstfer MB, Moy SS. Prosocial effects of oxytocin in two mouse models of autism spectrum disorders. Neuropharmacology. 2013 Sep;72187–196. [PMID: 23643748]

Question 5: Where Can I Turn for Services?

Selected Article
Boyd BA, Hume K, McBee MT, Alessandri M, Gutierrez A, Johnson L, Sperry L, Odom SL. Comparative efficacy of LEAP, TEACCH and non-model-specific special education programs for preschoolers with autism spectrum disorders. J Autism Dev Disord. 2014 Feb;44(2):366–380. [PMID: 23812661]

Broder-Fingert S, Shui A, Pulcini CD, Kurowski D, Perrin JM. Racial and ethnic differences in subspecialty service use by children with autism. Pediatrics. 2013 Jul;132(1):94–100. [PMID: 23776121]

Hill DA, Kearley R. Autism litigation: Outcomes for 2010, trends in decision making and changes in diagnostic criteria. Res Dev Disabil. 2013 May;34(5):1843–1848. [PMID: 23528441]

Selected Article
Nahmias AS, Kase C, Mandell DS. Comparing cognitive outcomes among children with autism spectrum disorders receiving community-based early intervention in one of three placements. Autism Int J Res Pract. 2014 Apr;18(3):311-320. [PMID: 23188885]

Warfield ME, Chiri G, Leutz WN, Timberlake M. Family well-being in a participant-directed autism waiver program: the role of relational coordination. J Intellect Disabil Res. 2013 Nov. [Epub ahead of print]

Question 6: What Does the Future Hold, Particularly for Adults?

Cheak-Zamora NC, Yang X, Farmer JE, Clark M. Disparities in transition planning for youth with autism spectrum disorder. Pediatrics. 2013 Mar;131(3):447–454. [PMID: 23400613]

Eack SM, Bahorik AL, Hogarty SS, Greenwald DP, Litschge MY, Mazefsky CA, Minshew NJ. Brief report: is cognitive rehabilitation needed in verbal adults with autism? Insights from initial enrollment in a trial of cognitive enhancement therapy. J Autism Dev Disord. 2013 Sep;43(9):2233–2237. [PMID: 23381484]

Eack SM, Greenwald DP, Hogarty SS, Bahorik AL, Litschge MY, Mazefsky CA, Minshew NJ. Cognitive enhancement therapy for adults with autism spectrum disorder: results of an 18-month feasibility study. J Autism Dev Disord. 2013 Dec;43(12):2866–2877. [PMID: 23619953]

Selected Article
Fein D, Barton M, Eigsti I-M, Kelley E, Naigles L, Schultz RT, Stevens M, Helt M, Orinstein A, Rosenthal M, Troyb E, Tyson K. Optimal outcome in individuals with a history of autism. J Child Psychol Psychiatry. 2013 Feb;54(2):195–205. [PMID: 23320807]

Howlin P, Savage S, Moss P, Tempier A, Rutter M. Cognitive and language skills in adults with autism: a 40-year follow-up. J Child Psychol Psychiatry. 2014 Jan;55(1):49–58. [PMID: 23848399]

Selected Article
Mavranezouli I, Megnin-Viggars O, Cheema N, Howlin P, Baron-Cohen S, Pilling S. The cost-effectiveness of supported employment for adults with autism in the United Kingdom. Autism Int J Res Pract. 2013 Oct. [Epub ahead of print] [PMID: 24126866]

Roux AM, Shattuck PT, Cooper BP, Anderson KA, Wagner M, Narendorf SC. Postsecondary employment experiences among young adults with an autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2013 Sep;52(9):931–939. [PMID: 23972695]

Taylor JL, Smith LE, Mailick MR. Engagement in vocational activities promotes behavioral development for adults with autism spectrum disorders. J Autism Dev Disord. 2013 Nov. [PMID: 24287880]

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Chlebowski C, Robins DL, Barton ML, Fein D. Large-scale use of the modified checklist for autism in low-risk toddlers. Pediatrics. 2013 Apr;131(4):e1121–1127. [PMID: 23530174]

Selected Article
Hewitt A, Gulaid A, Hamre K, Esler A, Punyko J, Reichle J, Reiff M. Minneapolis Somali autism spectrum disorder prevalence project: Community report 2013. (PDF – 2 MB) 2013 Dec.

Selected Article
Rice CE, Rosanoff M, Dawson G, Durkin MS, PhD, Croen LA, PhD, Singer A, Yeargin-Allsopp M. Evaluating changes in the prevalence of the autism spectrum disorders (ASDs). (PDF – 838 KB) Public Health Reviews. 2013 March;34(6):2.

Schendel DE, Bresnahan M, Carter KW, Francis RW, Gissler M, Grønborg TK, Gross R, Gunnes N, Hornig M, Hultman CM, Langridge A, Lauritsen MB, Leonard H, Parner ET, Reichenberg A, Sandin S, Sourander A, Stoltenberg C, Suominen A, Surén P, Susser E. The International Collaboration for Autism Registry Epidemiology (iCARE): multinational registry-based investigations of autism risk factors and trends. J Autism Dev Disord. 2013 Nov;43(11):2650–2663. [PMID: 23563868]

About the IACC

The Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating all activities concerning autism spectrum disorder (ASD) within the U.S. Department of Health and Human Services (HHS) and providing advice to the Secretary of HHS on issues related to autism. It was established by Congress under the Children's Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed under the Combating Autism Reauthorization Act (CARA) of 2011.

Membership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, parents of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. This makeup of the IACC membership is designed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by families and individuals affected by autism.

Under the CAA, the IACC is required to (1) develop and annually update a strategic plan for ASD research, (2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.

Through these and other activities, the IACC provides guidance to HHS and partners with the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.

IACC Member Roster

Chair

  • Thomas R. Insel, M.D.
    Director
    National Institute of Mental Health
    National Institutes of Health
    Bethesda, Maryland

Federal Members

  • James F. Battey, M.D., Ph.D.
    Director
    National Institute on Deafness and Other
    Communication Disorders
    National Institutes of Health
    Bethesda, Maryland
  • Linda Birnbaum, Ph.D.
    Director
    National Institute of Environmental Health
    Sciences and National Toxicology Program
    National Institutes of Health
    Research Triangle Park, North Carolina
  • Coleen Boyle, Ph.D., M.S. Hyg.
    Director
    National Center on Birth Defects and
    Developmental Disabilities
    Centers for Disease Control and Prevention
    Atlanta, Georgia
  • Francis S. Collins, M.D., Ph.D.
    Director
    National Institutes of Health
    Bethesda, Maryland
  • Tiffany R. Farchione, M.D.
    Medical Officer
    Division of Psychiatry Products
    Center for Drug Evaluation and Research
    U.S. Food and Drug Administration
    Silver Spring, Maryland
  • Alan E. Guttmacher, M.D.
    Director
    Eunice Kennedy Shriver National Institute
    of Child Health and Human Development
    National Institutes of Health
    Bethesda, Maryland
  • Laura Kavanagh, M.P.P.
    Director
    Division of Research, Training and Education
    Maternal and Child Health
    Health Resources and Service Administration
    Rockville, Maryland
  • Donna M. Kimbark, Ph.D.
    Program Manager
    Congressionally Directed Medical
    Research Programs
    U.S. Department of Defense
    Frederick, Maryland
  • Walter J. Koroshetz, M.D.
    Deputy Director
    National Institute of Neurological Disorders
    and Stroke
    National Institutes of Health
    Bethesda, Maryland
  • Sharon Lewis
    Senior Advisor on Disability Policy
    U.S. Department of Health and Human Services
    Principal Deputy Administrator
    Administration for Community Living
    Washington, DC
  • John P. O'Brien, M.A.
    Senior Policy Analyst
    Disabled and Elderly Health Programs Group
    Centers for Medicare & Medicaid Services
    Baltimore, Maryland
  • Linda K. Smith
    Deputy Assistant Secretary and
    Inter-Department Liaison for Early Childhood Development
    Administration for Children and Families
    Washington, DC
  • Michael K. Yudin
    Acting Assistant Secretary for Special Education and
    Rehabilitative Services
    Office of Special Education and Rehabiliative Services
    U.S. Department of Education
    Washington, DC

Public Members

  • Idil Abdull
    Parent
    Co-Founder
    Somali American Autism Foundation
    Minneapolis, Minnesota
  • James Ball, Ed.D., B.C.B.A.-D.
    President and CEO
    JB Autism Consulting
    Executive Chair, Board of Directors
    Autism Society
    Cranbury, New Jersey
  • Anshu Batra, M.D.
    Parent
    Developmental Pediatrician
    Our Special Kids
    Los Angeles, California
  • Noah Britton, M.A.
    Self Advocate
    Adjunct Professor of Psychology
    Bunker Hill Community College
    Salem, Massachusetts
  • Sally Burton-Hoyle, Ed.D.
    Family Member
    Associate Professor
    Department of Special Education
    Eastern Michigan University
    Ypsilanti, Michigan
  • Matthew J. Carey, Ph.D.
    Parent
    Contributor, Left Brain Right Brain Blog
    San Jose, California
  • Jose F. Cordero, M.D., M.P.H.
    Dean
    University of Puerto Rico
    Graduate School of Public Health
    Rio Piedras, Puerto Rico
  • Jan M. Crandy
    Parent
    Case Manager
    Nevada State Autism Treatment
    Assistance Program
    Chair
    Nevada Commission on Autism
    Spectrum Disorders
    Las Vegas, Nevada
  • Geraldine Dawson, Ph.D.
    Professor
    Department of Psychiatry and Behavioral Sciences
    Duke University Medical Center
    Durham, North Carolina
  • David S. Mandell, Sc.D.
    Associate Professor
    Department of Psychiatry and Pediatrics
    University of Pennsylvania
    School of Medicine
    Philadelphia, Pennsylvania
  • Lyn Redwood, R.N., M.S.N.
    Parent
    Co-Founder, Vice President
    and Board Member
    Coalition for SafeMinds
    Tyrone, Georgia
  • Scott Michael Robertson, Ph.D.
    Self Advocate
    President and Vice Chair of Development
    Autistic Self Advocacy Network
    University Park, Pennsylvania
  • John Elder Robison
    Neurodiversity Scholar in Residence
    College of William and Mary
    Williamsburg, Virginia

  • Alison Tepper Singer, M.B.A.
    Parent and Family Member
    Founder and President
    Autism Science Foundation
    New York, New York

Office of Autism Research Coordination (OARC) Staff List

  • Susan A. Daniels, Ph.D.
    Director, OARC
    Executive Secretary, IACC
  • Dawn A. Beraud, Ph.D.
    Science Policy Analyst
  • Emily B. Einstein, Ph.D.
    AAAS Science and
    Technology Policy Fellow
  • Nicole Jones, B.B.A.
    Senior Web Developer
  • Kipchumba Kitur, B.A.
    Operations Coordinator
  • Stephanie Mok, A.B.
    Science Policy Analyst
  • Miguelina Perez
    Management Analyst
  • Sarah E.V. Rhodes, Ph.D.
    Science Policy Analyst
  • Kerri Wachter
    Science Writer/Editor

Cover Design
NIH Medical Arts Branch

Copyright Information
All material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.

Suggested Citation
Interagency Autism Coordinating Committee (IACC). 2013 IACC Summary of Advances in Autism Spectrum Disorder Research. April 2014. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: http://iacc.hhs.gov/publications/summary-of-advances/2013/.

Appendices

 
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