Citation List – Articles Selected for the 2016 Summary of Advances

Question 1: When Should I Be Concerned?

Jones EJ, Venema K, Earl R, Lowy R, Barnes K, Estes A, Dawson G, Webb SJ. Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk. J Neurodev Disord. 2016 Mar 15;8:7. [PMID: 26981158]

Miller M, Iosif AM, Young GS, Hill M, Phelps Hanzel E, Hutman T, Johnson S, Ozonoff S. School-age outcomes of infants at risk for autism spectrum disorder. Autism Res. 2016 Jun;9(6):632-42. [PMID: 26451968]

Question 2: How Can I Understand What Is Happening?

Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs. Cell. 2016 Jul 14;166(2):299-313. [PMID: 27293187]

Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. 2016 Dec 15;540(7633):423-427. [PMID: 27919067]

Werling DM, Parikshak NN, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nat Commun. 2016 Feb 19;7:10717. [PMID: 26892004]

Question 3: What Caused This to Happen and Can It Be Prevented?

Eriksson JM, Lundström S, Lichtenstein P, Bejerot S, Eriksson E. Effect of co-twin gender on neurodevelopmental symptoms: a twin register study. Mol Autism. 2016 Jan 19;7:8. [PMID: 26793297]

Jokiranta-Olkoniemi E, Cheslack-Postava K, Sucksdorff D, Suominen A, Gyllenberg D, Chudal R, Leivonen S, Gissler M, Brown AS, Sourander A. Risk of psychiatric and neurodevelopmental disorders among siblings of probands with autism spectrum disorders. JAMA Psychiatry. 2016 Jun 1;73(6):622-9. [PMID: 27145529]

Zerbo O, Qian Y, Yoshida C, Fireman BH, Klein NP, Croen LA. Association between influenza infection and vaccination during pregnancy and risk of autism spectrum disorder. JAMA Pediatr. 2017 Jan 2;171(1):e163609. [Available online November 28, 2016] [PMID: 27893896]

Question 4: Which Treatments and Interventions Will Help?

Almirall D, DiStefano C, Chang YC, Shire S, Kaiser A, Lu X, Nahum-Shani I, Landa R, Mathy P, Kasari C. Longitudinal effects of adaptive interventions with a speech-generating device in minimally verbal children with ASD. J Clin Child Adolesc Psychol. 2016 Jul-Aug;45(4):442-56. [PMID: 26954267]

Chang YC, Shire SY, Shih W, Gelfand C, Kasari C. Preschool deployment of evidence-based social communication intervention: JASPER in the classroom. J Autism Dev Disord. 2016 Jun;46(6):2211-23. [PMID: 26936161]

Hampton LH, Kaiser AP. Intervention effects on spoken-language outcomes for children with autism: a systematic review and meta-analysis. J Intellect Disabil Res. 2016 May;60(5):444-63. [PMID: 27120988]

Kasari C, Dean M, Kretzmann M, Shih W, Orlich F, Whitney R, Landa R, Lord C, King B. Children with autism spectrum disorder and social skills groups at school: a randomized trial comparing intervention approach and peer composition. J Child Psychol Psychiatry. 2016 Feb;57(2):171-9. [PMID: 26391889]

Pickles A, Le Couteur A, Leadbitter K, Salomone E, Cole-Fletcher R, Tobin H, Gammer I, Lowry J, Vamvakas G, Byford S, Aldred C, Slonims V, McConachie H, Howlin P, Parr JR, Charman T, Green J. Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. Lancet. 2016 Nov 19;388(10059):2501-2509. [PMID: 27793431]

Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Transl Psychiatry. 2016 Nov 15;6(11):e948. [PMID: 27845779]

Question 5: Where Can I Turn for Services?

Leslie DL, Iskandarani K, Dick AW, Mandell DS, Yu H, Velott D, Agbese E, Stein BD. The effects of Medicaid home and community-based services waivers on unmet needs among children with autism spectrum disorder. Med Care. 2017 Jan;55(1):57-63. [Available online 2016] [PMID: 27547947]

Mandell DS, Barry CL, Marcus SC, Xie M, Shea K, Mullan K, Epstein AJ. Effects of autism spectrum disorder insurance mandates on the treated prevalence of autism spectrum disorder. JAMA Pediatr. 2016 Sep 1;170(9):887- 93. [PMID: 27399053]

Nguyen CT, Krakowiak P, Hansen R, Hertz-Picciotto I, Angkustsiri K. Sociodemographic disparities in intervention service utilization in families of children with autism spectrum disorder. J Autism Dev Disord. 2016 Dec;46(12):3729-3738. [PMID: 27639855]

Question 6: What Does the Future Hold, Particularly for Adults?

Hirvikoski T, Mittendorfer-Rutz E, Boman M, Larsson H, Lichtenstein P, Bölte S. Premature mortality in autism spectrum disorder. Br J Psychiatry. 2016 Mar;208(3):232-8. [PMID: 26541693]

Wehman P, Schall CM, McDonough J, Graham C, Brooke V, Riehle JE, Brooke A, Ham W, Lau S, Allen J, Avellone L. Effects of an employer-based intervention on employment outcomes for youth with significant support needs due to autism. Autism. 2016 May 5. [Epub ahead of print] [PMID: 27154907]

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

Christensen DL, Baio J, Van Naarden Braun K, Bilder D, Charles J, Constantino JN, Daniels J, Durkin MS, Fitzgerald RT, Kurzius-Spencer M, Lee LC, Pettygrove S, Robinson C, Schulz E, Wells C, Wingate MS, Zahorodny W, Yeargin-Allsopp M. Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2012. MMWR Surveill Summ. 2016 Apr 1;65(3):1-23. [PMID: 27031587]

Full Listing of Nominated Articles (Selected Articles Appear in *Bold)

Question 1: When Should I Be Concerned?

*Jones EJ, Venema K, Earl R, Lowy R, Barnes K, Estes A, Dawson G, Webb SJ. Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk. J Neurodev Disord. 2016 Mar 15;8:7. [PMID: 26981158]

McCormick C, Hepburn S, Young GS, Rogers SJ. Sensory symptoms in children with autism spectrum disorder, other developmental disorders and typical development: A longitudinal study. Autism. 2016 Jul;20(5):572-9. [PMID: 26395236]

*Miller M, Iosif AM, Young GS, Hill M, Phelps Hanzel E, Hutman T, Johnson S, Ozonoff S. School-age outcomes of infants at risk for autism spectrum disorder. Autism Res. 2016 Jun;9(6):632-42. [PMID: 26451968]

Question 2: How Can I Understand What Is Happening?

Dean DC 3rd, Travers BG, Adluru N, Tromp do PM, Destiche DJ, Samsin D, Prigge MB, Zielinski BA, Fletcher PT, Anderson JS, Froehlich AL, Bigler ED, Lange N, Lainhart JE, Alexander AL. Investigating the microstructural correlation of white matter in autism spectrum disorder. Brain Connect. 2016 Jun;6(5):415-33. [PMID: 27021440]

D’Mello AM, Moore DM, Crocetti D, Mostofsky SH, Stoodley CJ. Cerebellar gray matter differentiates children with early language delay in autism. Autism Res. 2016 Nov;9(11):1191-1204. [PMID: 27868392]

Falahpour M, Thompson WK, Abbott AE, Jahedi A, Mulvey ME, Datko M, Liu TT, Müller RA. Underconnected, but not broken? Dynamic functional connectivity MRI shows underconnectivity in autism is linked to increased intraindividual variability across time. Brain Connect. 2016 Jun;6(5):403-14. [PMID: 26973154]

Green SA, Hernandez L, Bookheimer SY, Dapretto M. Salience network connectivity in autism is related to brain and behavioral markers of sensory overresponsivity. J Am Acad Child Adolesc Psychiatry. 2016 Jul;55(7):618-626.e1. [PMID: 27343889]

Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria KC, Beltrao-Braga PC, Trujillo CA, Mendes AP, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand KJ, Pierce K, Eichenfield L, Pramparo T, Eyler LT, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2016 Jul 5. [Epub ahead of print] [PMID: 27378147]

Nordahl CW, Mello M, Shen AM, Shen MD, Vismara LA, Li D, Harrington K, Tanase C, Goodlin-Jones B, Rogers S, Abbeduto L, Amaral DG. Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation. J Neurodev Disord. 2016 May 5;8:20. [PMID: 27158271]

*Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs. Cell. 2016 Jul 14;166(2):299-313. [PMID: 27293187]

*Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. 2016 Dec 15;540(7633):423-427. [PMID: 27919067]

Shen MD, Li DD, Keown CL, Lee A, Johnson RT, Angkustsiri K, Rogers SJ, Müller RA, Amaral DG, Nordahl CW. Functional connectivity of the amygdala is disrupted in preschool-aged children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2016 Sep;55(9):817-24. [PMID: 27566123]

Tao J, Wu H, Coronado AA, de Laittre E, Osterweil EK, Zhang Y, Bear MF. Negative allosteric modulation of mGluR5 partially corrects pathophysiology in a mouse model of Rett syndrome. J Neurosci. 2016 Nov 23;36(47):11946- 11958. [PMID: 27881780]

*Werling DM, Parikshak NN, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nat Commun. 2016 Feb 19;7:10717. [PMID: 26892004]

Yi F, Danko T, Botelho SC, Patzke C, Pak C, Wernig M, Südhof TC. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science. 2016 May 6;352(6286):aaf2669. [PMID: 26966193]

Question 3: What Caused This to Happen and Can It Be Prevented?

Avella-Garcia CB, Julvez J, Fortuny J, Rebordosa C, García-Esteban R, Galán IR, Tardón A, Rodríguez-Bernal CL, Iñiguez C, Andiarena A, Santa-Marina L, Sunyer J. Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms. Int J Epidemiol. 2016 Jun 28. pii: dyw115. [Epub ahead of print] [PMID: 27353198]

Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike SI, Korf I, LaSalle JM. Cumulative impact of polychlorinated biphenyl and large chromosomal duplications on DNA methylation, chromatin, and expression of autism candidate genes. Cell Rep. 2016 Dec 13;17(11):3035-3048. [PMID: 27974215]

*Eriksson JM, Lundström S, Lichtenstein P, Bejerot S, Eriksson E. Effect of co-twin gender on neurodevelopmental symptoms: a twin register study. Mol Autism. 2016 Jan 19;7:8. [PMID: 26793297]

*Jokiranta-Olkoniemi E, Cheslack-Postava K, Sucksdorff D, Suominen A, Gyllenberg D, Chudal R, Leivonen S, Gissler M, Brown AS, Sourander A. Risk of psychiatric and neurodevelopmental disorders among siblings of probands with autism spectrum disorders. JAMA Psychiatry. 2016 Jun 1;73(6):622-9. [PMID: 27145529]

*Zerbo O, Qian Y, Yoshida C, Fireman BH, Klein NP, Croen LA. Association between influenza infection and vaccination during pregnancy and risk of autism spectrum disorder. JAMA Pediatr. 2017 Jan 2;171(1):e163609. [Available online November 28, 2016] [PMID: 27893896]

Question 4: Which Treatments and Interventions Will Help?

*Almirall D, DiStefano C, Chang YC, Shire S, Kaiser A, Lu X, Nahum-Shani I, Landa R, Mathy P, Kasari C. Longitudinal effects of adaptive interventions with a speech-generating device in minimally verbal children with ASD. J Clin Child Adolesc Psychol. 2016 Jul-Aug;45(4):442-56. [PMID: 26954267]

Anderson A, Locke J, Kretzmann M, Kasari C; AIR-B Network. Social network analysis of children with autism spectrum disorder: Predictors of fragmentation and connectivity in elementary school classrooms. Autism. 2016 Aug;20(6):700-9. [PMID: 26567264]

Camargo SPH, Rispoli M, Ganz J, Hong ER, Davis H, Mason R. Behaviorally based interventions for teaching social interaction skills to children with ASD in inclusive settings: A meta-analysis. J Behav Educ. 2016 Jun 1;25(2):223-48. [doi: 10.1007/s10864-015-9240-1]

*Chang YC, Shire SY, Shih W, Gelfand C, Kasari C. Preschool deployment of evidence-based social communication intervention: JASPER in the classroom. J Autism Dev Disord. 2016 Jun;46(6):2211-23. [PMID: 26936161]

Cihak DF, Moore EJ, Wright RE, McMahon DD, Gibbons MM, Smith CS. Evaluating augmented reality to complete a chain task for elementary students with autism. J Spec Educ Tech. 2016 May; 31(2):99-108. [doi: 10.1177/0162643416651724]

Corbett BA, Key AP, Qualls L, Fecteau S, Newsom C, Coke C, Yoder P. Improvement in social competence using a randomized trial of a theatre intervention for children with autism spectrum disorder. J Autism Dev Disord. 2016 Feb;46(2):658-72. [PMID: 26419766]

Flores MM, Schweck KB, Hinton V. Teaching language skills to preschool students with developmental delays and autism spectrum disorder using language for learning. Rural Spec Educ Q. 2016 Apr;35(1):3-12. [Link not available]

Garbacz SA, McIntyre LL. Conjoint behavioral consultation for children with autism spectrum disorder. Sch Psychol Q. 2016 Dec;31(4):450-466. [PMID: 25688808]

*Hampton LH, Kaiser AP. Intervention effects on spoken-language outcomes for children with autism: a systematic review and meta-analysis. J Intellect Disabil Res. 2016 May;60(5):444-63. [PMID: 27120988]

*Kasari C, Dean M, Kretzmann M, Shih W, Orlich F, Whitney R, Landa R, Lord C, King B. Children with autism spectrum disorder and social skills groups at school: a randomized trial comparing intervention approach and peer composition. J Child Psychol Psychiatry. 2016 Feb;57(2):171-9. [PMID: 26391889]

Park SY, Cervesi C, Galling B, Molteni S, Walyzada F, Ameis SH, Gerhard T, Olfson M, Correll CU. Antipsychotic use trends in youth with autism spectrum disorder and/or intellectual disability: a meta-analysis. J Am Acad Child Adolesc Psychiatry. 2016 Jun;55(6):456-468.e4. [PMID: 27238064]

*Pickles A, Le Couteur A, Leadbitter K, Salomone E, Cole-Fletcher R, Tobin H, Gammer I, Lowry J, Vamvakas G, Byford S, Aldred C, Slonims V, McConachie H, Howlin P, Parr JR, Charman T, Green J. Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial. Lancet. 2016 Nov 19;388(10059):2501-2509. [PMID: 27793431]

Srinivasan SM, Eigsti IM, Neelly L, Bhat AN. The effects of embodied rhythm and robotic interventions on the spontaneous and responsive social attention patterns of children with autism spectrum disorder (ASD): a pilot randomized controlled trial. Res Autism Spectr Disord. 2016 Jul;27:54-72. [PMID: 27453721]

Thiemann-Bourque K, Brady N, McGuff S, Stump K, Naylor A. Picture exchange communication system and pals: a peer-mediated augmentative and alternative communication intervention for minimally verbal preschoolers with autism. J Speech Lang Hear Res. 2016 Oct 1;59(5):1133-1145. [PMID: 27679841]

Yakubova G, Zeleke WA. A problem-solving intervention using iPads to improve transition-related task performance of students with autism spectrum disorder. J Spec Educ Tech. 2016;31(2):77-86. [Link not available]

*Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Transl Psychiatry. 2016 Nov 15;6(11):e948. [PMID: 27845779]

Young KR, Radley KC, Jenson WR, West RP, Clare SK. Peer-facilitated discrete trial training for children with autism spectrum disorder. Sch Psychol Q. 2016 Dec;31(4):507-521. [PMID: 27929320]

Question 5: Where Can I Turn for Services?

Kiely B, Migdal TR, Vettam S, Adesman A. Prevalence and correlates of elopement in a nationally representative sample of children with developmental disabilities in the United States. PLoS One. 2016 Feb 4;11(2):e0148337. [PMID: 26845701]

*Leslie DL, Iskandarani K, Dick AW, Mandell DS, Yu H, Velott D, Agbese E, Stein BD. The effects of Medicaid home and community-based services waivers on unmet needs among children with autism spectrum disorder. Med Care. 2017 Jan;55(1):57-63. [Available online 2016] [PMID: 27547947]

*Mandell DS, Barry CL, Marcus SC, Xie M, Shea K, Mullan K, Epstein AJ. Effects of autism spectrum disorder insurance mandates on the treated prevalence of autism spectrum disorder. JAMA Pediatr. 2016 Sep 1;170(9):887- 93. [PMID: 27399053]

*Nguyen CT, Krakowiak P, Hansen R, Hertz-Picciotto I, Angkustsiri K. Sociodemographic disparities in intervention service utilization in families of children with autism spectrum disorder. J Autism Dev Disord. 2016 Dec;46(12):3729-3738. [PMID: 27639855]

Question 6: What Does the Future Hold, Particularly for Adults?

*Hirvikoski T, Mittendorfer-Rutz E, Boman M, Larsson H, Lichtenstein P, Bölte S. Premature mortality in autism spectrum disorder. Br J Psychiatry. 2016 Mar;208(3):232-8. [PMID: 26541693]

Maisel ME, Stephenson KG, South M, Rodgers J, Freeston MH, Gaigg SB. Modeling the cognitive mechanisms linking autism symptoms and anxiety in adults. J Abnorm Psychol. 2016 Jul;125(5):692-703. [PMID: 27196436]

Strang JF, Meagher H, Kenworthy L, de Vries AL, Menvielle E, Leibowitz S, Janssen A, Cohen-Kettenis P, Shumer DE, Edwards-Leeper L, Pleak RR, Spack N, Karasic DH, Schreier H, Balleur A, Tishelman A, Ehrensaft D, Rodnan L, Kuschner ES, Mandel F, Caretto A, Lewis HC, Anthony LG. Initial clinical guidelines for co-occurring autism spectrum disorder and gender dysphoria or incongruence in adolescents. J Clin Child Adolesc Psychol. 2016 Oct 24:1-11. [PMID: 27775428]

*Wehman P, Schall CM, McDonough J, Graham C, Brooke V, Riehle JE, Brooke A, Ham W, Lau S, Allen J, Avellone L. Effects of an employer-based intervention on employment outcomes for youth with significant support needs due to autism. Autism. 2016 May 5. [Epub ahead of print] [PMID: 27154907]

Woodman AC, Mailick MR, Greenberg JS. Trajectories of internalizing and externalizing symptoms among adults with autism spectrum disorders. Dev Psychopathol. 2016 May;28(2):565-81. [PMID: 26612272]

Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?

*Christensen DL, Baio J, Van Naarden Braun K, Bilder D, Charles J, Constantino JN, Daniels J, Durkin MS, Fitzgerald RT, Kurzius-Spencer M, Lee LC, Pettygrove S, Robinson C, Schulz E, Wells C, Wingate MS, Zahorodny W, Yeargin- Allsopp M. Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2012. MMWR Surveill Summ. 2016 Apr 1;65(3):1-23. [PMID: 27031587]

Hewitt A, Hall-Lande J, Hamre K, Esler AN, Punyko J, Reichle J, Gulaid AA. Autism spectrum disorder (ASD) prevalence in Somali and non-Somali children. J Autism Dev Disord. 2016 Aug;46(8):2599-608. [PMID: 27106569]

About the IACC

The Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating all activities concerning autism spectrum disorder (ASD) within the U.S. Department of Health and Human Services (HHS) and providing advice to the Secretary of HHS on issues related to autism. It was established by Congress under the Children’s Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed under the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2014.

Membership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, family members of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. This IACC membership is composed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by families and individuals affected by autism.

Under the CAA and subsequent authorizations, the IACC is required to (1) develop and annually update a strategic plan for ASD research, (2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.

Through these and other activities, the IACC provides guidance to HHS and partners with the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.

For more information about the IACC, see http://www.iacc.hhs.gov.

Interagency Autism Coordinating Committee Member Roster

Federal Members

Public Members

Office of Autism Research Coordination Staff List

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All material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.

Suggested Citation
Interagency Autism Coordinating Committee (IACC). 2016 IACC Summary of Advances in Autism Spectrum Disorder Research. April 2017. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: http://iacc.hhs.gov/publications/summary-of-advances/2016/.