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Summary of Advances Cover 2017

Summary of Advances

In Autism Spectrum Disorder Research



Full Listing of Nominated Articles (Selected Articles Appear in *Bold)

Question 1: How Can I Recognize The Signs Of ASD, and Why Is Early Detection So Important?

*Donohue MR, Childs AW, Richards M, Robins DL. Race influences parent report of concerns about symptoms of autism spectrum disorder. Autism. 2017 Nov 1:1362361317722030. [Epub ahead of print] [PMID: 29100475]

*Emerson RW, Adams C, Nishino T, Hazlett HC, Wolff JJ, Zwaigenbaum L, Constantino JN, Shen MD, Swanson MR, Elison JT, Kandala S, Estes AM, Botteron KN, Collins L, Dager SR, Evans AC, Gerig G, Gu H, McKinstry RC, Paterson S, Schultz RT, Styner M; IBIS Network, Schlaggar BL, Pruett JR Jr, Piven J. Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci Transl Med. 2017 Jun 7;9(393). pii: eaag2882. [PMID: 28592562]

*Hazlett HC, Gu H, Munsell BC, Kim SH, Styner M, Wolff JJ, Elison JT, Swanson MR, Zhu H, Botteron KN, Collins DL, Constantino JN, Dager SR, Estes AM, Evans AC, Fonov VS, Gerig G, Kostopoulos P, McKinstry RC, Pandey J, Paterson S, Pruett JR, Schultz RT, Shaw DW, Zwaigenbaum L, Piven J; IBIS Network; Clinical Sites; Data Coordinating Center; Image Processing Core; Statistical Analysis. Early brain development in infants at high risk for autism spectrum disorder. Nature. 2017 Feb 15;542(7641):348-351. [PMID: 28202961]

Hull L, Mandy W, Petrides KV. Behavioural and cognitive sex/gender differences in autism spectrum condition and typically developing males and females. Autism. 2017 Aug;21(6):706-727. [PMID: 28749232]

Lewis JD, Evans AC, Pruett JR Jr, Botteron KN, McKinstry RC, Zwaigenbaum L, Estes AM, Collins DL, Kostopoulos P, Gerig G, Dager SR, Paterson S, Schultz RT, Styner MA, Hazlett HC, Piven J; Infant Brain Imaging Study Network. The emergence of network inefficiencies in infants with autism spectrum disorder. Biol Psychiatry. 2017 Aug 1;82(3):176-185.[PMID: 28460842]

Mandy W, Wang A, Lee I, Skuse D. Evaluating social (pragmatic) communication disorder. J Child Psychol Psychiatry. 2017 Oct;58(10):1166-1175. [PMID: 28741680]

*Mazurek MO, Lu F, Symecko H, Butter E, Bing NM, Hundley RJ, Poulsen M, Kanne SM, Macklin EA, Handen BL. A prospective study of the concordance of DSM-IV and DSM-5 diagnostic criteria for autism spectrum disorder.J Autism Dev Disord. 2017 Sep;47(9):2783-2794. [PMID: 28620892]

McIntyre NS, Solari EJ, Grimm RP, E Lerro L, E Gonzales J, Mundy PC. A comprehensive examination of reading heterogeneity in students with high functioning autism: distinct reading profiles and their relation to autism symptom severity. J Autism Dev Disord. 2017 Apr;47(4):1086-1101. [PMID: 28160222]

Moody EJ, Reyes N, Ledbetter C, Wiggins L, DiGuiseppi C, Alexander A, Jackson S, Lee LC, Levy SE, Rosenberg SA. Screening for autism with the SRS and SCQ: variations across demographic, developmental and behavioral factors in preschool children. J Autism Dev Disord. 2017 Nov;47(11):3550-3561. [PMID: 28856480]

Sabapathy T, Madduri N, Deavenport-Saman A, Zamora I, Schrager SM, Vanderbilt DL. Parent-reported strengths in children with autism spectrum disorders at the time of an interdisciplinary diagnostic evaluation. J Dev Behav Pediatr. 2017 Apr;38(3):181-186. [PMID: 28368969]

Shen MD, Kim SH, McKinstry RC, Gu H, Hazlett HC, Nordahl CW, Emerson RW, Shaw D, Elison JT, Swanson MR, Fonov VS, Gerig G, Dager SR, Botteron KN, Paterson S, Schultz RT, Evans AC, Estes AM, Zwaigenbaum L, Styner MA, Amaral DG, Piven J; Infant Brain Imaging Study Network; Infant Brain Imaging Study Network, The Infant Brain Imaging Study (IBIS) Network is a National Institutes of Health–funded Autism Center of Excellence project and consists of a consortium of eight universities in the United States and Canada, Piven J, Hazlett HC, Chappell C, Dager S, Estes A, Shaw D, Botteron K, McKinstry R, Constantino J, Pruett J, Schultz R, Zwaigenbaum L, Elison J, Evans AC, Collins DL, Pike GB, Fonov V, Kostopoulos P, Das S, Gerig G, Styner M, Gu H. Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism. Biol Psychiatry. 2017 Aug 1;82(3):186-193. [PMID: 28392081]

Wolff JJ, Swanson MR, Elison JT, Gerig G, Pruett JR Jr, Styner MA, Vachet C, Botteron KN, Dager SR, Estes AM, Hazlett HC, Schultz RT, Shen MD, Zwaigenbaum L, Piven J; IBIS Network. Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism. Mol Autism. 2017 Mar 4;8:8. [PMID: 28316772]

Question 2: What Is the Biology Underlying ASD?

Bruno JL, Romano D, Mazaika P, Lightbody AA, Hazlett HC, Piven J, Reiss AL. Longitudinal identification of clinically distinct neurophenotypes in young children with fragile X syndrome. Proc Natl Acad Sci. U S A. 2017 Oct 3;114(40):10767-10772. [PMID: 28923933]

*Constantino JN, Kennon-McGill S, Weichselbaum C, Marrus N, Haider A, Glowinski AL, Gillespie S, Klaiman C, Klin A, Jones W. Infant viewing of social scenes is under genetic control and is atypical in autism. Nature. 2017 Jul 20;547(7663):340-344. [PMID: 28700580]

Duvekot J, van der Ende J, Verhulst FC, Greaves-Lord K. Examining bidirectional effects between the autism spectrum disorder (ASD) core symptom domains and anxiety in children with ASD. J Child Psychol Psychiatry. 2017 Oct 27. [Epub ahead of print] [PMID: 29076153]

Ecker C, Andrews DS, Gudbrandsen CM, Marquand AF, Ginestet CE, Daly EM, Murphy CM, Lai MC, Lombardo MV, Ruigrok AN, Bullmore ET, Suckling J, Williams SC, Baron-Cohen S, Craig MC, Murphy DG; Medical Research Council Autism Imaging Multicentre Study (MRC AIMS) Consortium. Association between the probability of autism spectrum disorder and normative sex-related phenotypic diversity in brain structure. JAMA Psychiatry. 2017 Apr 1;74(4):329-338. [PMID: 28196230]

Eggebrecht AT, Elison JT, Feczko E, Todorov A, Wolff JJ, Kandala S, Adams CM, Snyder AZ, Lewis JD, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans A, Hazlett HC, Dager S, Paterson SJ, Schultz RT, Styner MA, Gerig G, Das S, Kostopoulos P; IBIS Network, Schlaggar BL, Petersen SE, Piven J, Pruett JR Jr. Joint attention and brain functional connectivity in infants and toddlers. Cereb Cortex. 2017 Mar 1;27(3):1709-1720. [PMID: 28062515]

Gupta AR, Westphal A, Yang DYJ, Sullivan CAW, Eilbott J, Zaidi S, Voos A, Vander Wyk BC, Ventola P, Waqar Z, Fernandez TV, Ercan-Sencicek AG, Walker MF, Choi M, Schneider A, Hedderly T, Baird G, Friedman H, Cordeaux C, Ristow A, Shic F, Volkmar FR, Pelphrey KA. Neurogenetic analysis of childhood disintegrative disorder. Mol Autism. 2017 Apr 4;8:19. [PMID: 28392909]

Khundrakpam BS, Lewis JD, Kostopoulos P, Carbonell F, Evans AC. Cortical thickness abnormalities in autism spectrum disorders through late childhood, adolescence, and adulthood: a large-scale MRI study. Cereb Cortex. 2017 Mar 1;27(3):1721-1731. [PMID: 28334080]

Palmer N, Beam A, Agniel D, Eran A, Manrai A, Spettell C, Steinberg G, Mandl K, Fox K, Nelson SF, Kohane I. Association of sex with recurrence of autism spectrum disorder among siblings. JAMA Pediatr. 2017 Nov 1;171(11):1107-1112. [PMID: 28973142]

Sethna F, Feng W, Ding Q, Robison AJ, Feng Y, Wang H. Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model. Nat Commun. 2017 Feb 20;8:14359. [PMID: 28218269]

Silverman LB, Eigsti IM, Bennetto L. I tawt i taw a puddy tat: Gestures in canary row narrations by high-functioning youth with autism spectrum disorder. Autism Res. 2017 Aug;10(8):1353-1363. [PMID: 28371492]

*Solomon M, Iosif AM, Reinhardt VP, Libero LE, Nordahl CW, Ozonoff S, Rogers SJ, Amaral DG. What will my child’s future hold? Phenotypes of intellectual development in 2-8-year-olds with autism spectrum disorder. Autism Res. 2017 Oct 27. [Epub ahead of print] [PMID: 29076255]

Weir RK, Bauman MD, Jacobs B, Schumann CM. Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains. J Comp Neurol. 2018 Feb 1;526(2):262-274. [Epub 2017 Oct 26] [PMID: 28929566]

Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?

*Andrews SV, Ellis SE, Bakulski KM, Sheppard B, Croen LA, Hertz-Picciotto I, Newschaffer CJ, Feinberg AP, Arking DE, Ladd-Acosta C, Fallin MD. Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder. Nat Commun. 2017 Oct 24;8(1):1011. [PMID: 29066808]

*Arora M, Reichenberg A, Willfors C, Austin C, Gennings C, Berggren S, Lichtenstein P, Anckarsäter H, Tammimies K, Bölte S. Fetal and postnatal metal dysregulation in autism. Nat Commun. 2017 Jun 1;8:15493. [PMID: 28569757]

Bishop SL, Farmer C, Bal V, Robinson EB, Willsey AJ, Werling DM, Havdahl KA, Sanders SJ, Thurm A. Identification of developmental and behavioral markers associated with genetic abnormalities in autism spectrum disorder. Am J Psychiatry. 2017 Jun 1;174(6):576-585. [PMID: 28253736]

*Brucato M, Ladd-Acosta C, Li M, Caruso D, Hong X, Kaczaniuk J, Stuart EA, Fallin MD, Wang X. Prenatal exposure to fever is associated with autism spectrum disorder in the Boston Birth Cohort. Autism Res. 2017 Nov;10(11):1878-1890. [PMID: 28799289]

Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier RA, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017 Aug;20(8):1043-1051. [PMID: 28628100]

Golding J, Ellis G, Gregory S, Birmingham K, Iles-Caven Y, Rai D, Pembrey M. Grand-maternal smoking in pregnancy and grandchild’s autistic traits and diagnosed autism. Sci Rep. 2017 Apr 27;7:46179. [PMID: 28448061]

Kim D, Volk H, Girirajan S, Pendergrass S, Hall MA, Verma SS, Schmidt RJ, Hansen RL, Ghosh D, Ludena- Rodriguez Y, Kim K, Ritchie MD, Hertz-Picciotto I, Selleck SB. The joint effect of air pollution exposure and copy number variation on risk for autism. Autism Res. 2017 Sep;10(9):1470-1480. [PMID: 28448694]

Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017 Sep 28;549(7673):528-532. [PMID: 28902840]

Kosmicki JA, Samocha KE, Howrigan DP, Sanders SJ, Slowikowski K, Lek M, Karczewski KJ, Cutler DJ, Devlin B, Roeder K, Buxbaum JD, Neale BM, MacArthur DG, Wall DP, Robinson EB, Daly MJ. Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples. Nat Genet. 2017 Apr;49(4):504-510. [PMID: 28191890]

Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D’Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM; Autism Sequencing Consortium Church GM, Scherer SW, Buxbaum JD, Walsh CA. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nat Neurosci. 2017 Sep;20(9):1217-1224. [PMID: 28714951]

Pardo CA, Farmer CA, Thurm A, Shebl FM, Ilieva J, Kalra S, Swedo S. Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study. Mol Autism. 2017 Jan 5;8:1. [PMID: 28070266]

*Raghavan R, Riley AW, Volk H, Caruso D, Hironaka L, Sices L, Hong X, Wang G, Ji Y, Brucato M, Wahl A, Stivers T, Pearson C, Zuckerman B, Stuart EA, Landa R, Fallin MD, Wang X. Maternal multivitamin intake, plasma folate and vitamin B12 levels and autism spectrum disorder risk in offspring. Paediatr Perinat Epidemiol. 2018 Jan;32(1):100- 111. [Epub 2017 Oct 6] [PMID: 28984369]

Tabet A, Rolland T, Ducloy M, Lévy J, Buratti J, Mathier A, Haye D, Perrin L, Dupont C, Passemard S, Capri Y, Verloes A, Drunat, S, Keren B, Mignot C, Marey I, Jacquette A, Whalen S, Pipras E, Benzacken B, Chantot- Bastaraud S, Afenjar A, Héron D, Le Caignec C, Beneteau C, Pichon O, Isidor B, David A, El Khattabi L, Kemeny S, Gouas L, Vago P, Mosca-Boidron A, Faivre L, Missirian C, Philip N, Sanlaville D, Edery P, Satre V, Coutton C, Devillard F, Dieterich K, Vuillaume M, Rooryck C, Lacombe D, Pinson L, Gatinois V, Puechberty J, Chiesa J, Lespinasse J, Dubourg C, Quelin C, Fradin M, Journel H, Toutain A, Martin D, Benmansour A, Leblond CS, Toro R, Amsellem F, Delome R, Bourgeron T. A framework to identify contributing genes in patients with Phelan-McDermid syndrome. NPJ Genom Med. 2017 Oct 23;2:32. [PMID: 29263841]

Turner TN, Coe BP, Dickel DE, Hoekzema K, Nelson BJ, Zody MC, Kronenberg ZN, Hormozdiari F, Raja A, Pennacchio LA, Darnell RB, Eichler EE. Genomic patterns of de novo mutation in simplex autism. Cell. 2017 Sep 27. pii: S0092-8674(17)31006-1. [PMID: 28965761]

*Viktorin A, Uher R, Reichenberg A, Levine SZ, Sandin S. Autism risk following antidepressant medication during pregnancy. Psychol Med. 2017 Dec;47(16):2787-2796. [PMID: 28528584]

*Wang M, Li K, Zhao D, Li L. The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis. Mol Autism. 2017 Oct 2;8:51. [PMID: 29026508]

Webb SJ, Garrison MM, Bernier R, McClintic AM, King BH, Mourad PD. Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound. Autism Res. 2017 Mar;10(3):472-484. [PMID: 27582229]

Weiner DJ, Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, Samocha KE, Goldstein JI, Okbay A, Bybjerg- Grauholm J, Werge T, Hougaard DM, Taylor J; iPSYCH-Broad Autism Group; Psychiatric Genomics Consortium Autism Group, Skuse D, Devlin B, Anney R, Sanders SJ, Bishop S, Mortensen PB, Børglum AD, Smith GD, Daly MJ, Robinson EB. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet. 2017 Jul;49(7):978-985. [PMID: 28504703]

Yuen RKC, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D’Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW. Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder. Nat Neurosci. 2017 Apr;20(4):602-611. [PMID: 28263302]

Question 4: Which Treatments and Interventions Will Help?

Brian JA, Smith IM, Zwaigenbaum L, Bryson SE. Cross-site randomized control trial of the Social ABCs caregiver-mediated intervention for toddlers with autism spectrum disorder. Autism Res. 2017 Oct;10(10):1700- 1711. [PMID: 28574669]

*Chatham CH, Taylor KI, Charman T, Liogier D’ardhuy X, Eule E, Fedele A, Hardan AY, Loth E, Murtagh L, Del Valle Rubido M, San Jose Caceres A, Sevigny J, Sikich L, Snyder L, Tillmann JE, Ventola PE, Walton-Bowen KL, Wang PP, Willgoss T, Bolognani F. Adaptive behavior in autism: minimal clinically important differences on the Vineland-II. Autism Res. 2017 Sep 21. [Epub ahead of print] [PMID: 28941213]

Corbett BA, Blain SD, Ioannou S, Balser M. Changes in anxiety following a randomized control trial of a theatre-based intervention for youth with autism spectrum disorder. Autism. 2017 Apr;21(3):333-343. [PMID: 27154909]

Drmic IE, Aljunied M, Reaven J. Feasibility, acceptability and preliminary treatment outcomes in a school-based CBT intervention program for adolescents with ASD and anxiety in Singapore. J Autism Dev Disord. 2017 Dec;47(12):3909-3929. [PMID: 28101845]

*Handen BL, Anagnostou E, Aman MG, Sanders KB, Chan J, Hollway JA, Brian J, Arnold LE, Capano L, Williams C, Hellings JA, Butter E, Mankad D, Tumuluru R, Kettel J, Newsom CR, Peleg N, Odrobina D, McAuliffe-Bellin S, Marler S, Wong T, Wagner A, Hadjiyannakis S, Macklin EA, Veenstra-VanderWeele J. A randomized, placebo-controlled trial of metformin for the treatment of overweight induced by antipsychotic medication in young people with autism spectrum disorder: open-label extension. J Am Acad Child Adolesc Psychiatry. 2017 Oct;56(10):849-856.e6. [PMID: 28942807]

*Jones EJ, Dawson G, Kelly J, Estes A, Webb SJ. Parent-delivered early intervention in infants at risk for ASD: effects on electrophysiological and habituation measures of social attention. Autism Res. 2017 May;10(5):961-972. [PMID: 28244271]

Keefer A, Kreiser NL, Singh V, Blakeley-Smith A, Duncan A, Johnson C, Klinger L, Meyer A, Reaven J, Vasa RA. Intolerance of uncertainty predicts anxiety outcomes following CBT in youth with ASD. J Autism Dev Disord. 2017 Dec;47(12):3949-3958. [PMID: 27405445]

Lake JK, Denton D, Lunsky Y, Shui AM, Veenstra-VanderWeele J, Anagnostou E. Medical conditions and demographic, service and clinical factors associated with atypical antipsychotic medication use among children with an autism spectrum disorder. J Autism Dev Disord. 2017 May;47(5):1391-1402. [PMID: 28210827]

Mruzek DW, McAleavey S, Loring WA, Butter E, Smith T, McDonnell E, Levato L, Aponte C, Travis RP, Aiello RE, Taylor CM, Wilkins JW, Corbett-Dick P, Finkelstein DM, York AM, Zanibbi K. A pilot investigation of an iOS-based app for toilet training children with autism spectrum disorder. Autism. 2017 Dec 1:1362361317741741. [Epub ahead of print] [PMID: 29212345]

Parker KJ, Oztan O, Libove RA, Sumiyoshi RD, Jackson LP, Karhson DS, Summers JE, Hinman KE, Motonaga KS, Phillips JM, Carson DS, Garner JP, Hardan AY. Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism. Proc Natl Acad Sci USA. 2017 Jul 25;114(30):8119-8124. [PMID: 28696286]

Sathe N, Andrews JC, McPheeters ML, Warren ZE. Nutritional and dietary interventions for autism spectrum disorder: a systematic review. Pediatrics. 2017 Jun;139(6). pii: e20170346. [PMID: 28562286]

Shire SY, Chang YC, Shih W, Bracaglia S, Kodjoe M, Kasari C. Hybrid implementation model of community-partnered early intervention for toddlers with autism: a randomized trial. J Child Psychol Psychiatry. 2017 May;58(5):612-622. [PMID: 27966784]

Strain PS. Four-year follow-up of children in the LEAP Randomized Trial: some planned and accidental findings. Top Early Childhood Sp Educ. 2017 Jun 23;1-6. [available at:]

Weitlauf AS, Sathe N, McPheeters ML, Warren ZE. Interventions targeting sensory challenges in children with autism spectrum disorder – an update [internet]. AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 May. Report No.: 17-EHC004-EF. [PMID: 29064644]

Question 5: What Kinds Of Services and Supports are Needed To Maximize Quality Of Life For People On The Autism Spectrum?

*Barry CL, Epstein AJ, Marcus SC, Kennedy-Hendricks A, Candon MK, Xie M, Mandell DS. Effects of state insurance mandates on health care use and spending for autism spectrum disorder. Health Affairs (Millwood). 2017 Oct 1; 36(10), 1754-1761. [PMID: 28971920]

Caron V, Bérubé A, Paquet A. Implementation evaluation of early intensive behavioral intervention programs for children with autism spectrum disorders: A systematic review of studies in the last decade. Eval Program Plann. 2017 Jun;62:1-8. [PMID: 28189054]

Chou Y, Wehmeyer ML, Palmer SB, Lee J. Comparisons of self-determination among students with autism, intellectual disability, and learning disabilities: a multivariate analysis. Foc on Autism and Other Dev Disabil. 2017 Jun 1;32(2):124-132. [available at:]]

*Cidav Z, Munson J, Estes A, Dawson G, Rogers S, Mandell D. Cost offset associated with Early Start Denver Model for children with autism. J Am Acad Child Adolesc Psychiatry. 2017 Sep;56(9):777-783. [PMID: 28838582]

Hepburn SL. Strengthening informal supports to promote behavioral health of youth with intellectual and/or developmental disabilities in rural communities. International Rev of Res in Dev Disabil. 2017;53:203-234. [available at:]

Jamison JM, Fourie E, Siper PM, Trelles MP, George-Jones J, Buxbaum Grice A, Krata J, Holl E, Shaoul J, Hernandez B, Mitchell L, McKay MM, Buxbaum JD, Kolevzon A. Examining the efficacy of a family peer advocate model for Black and Hispanic caregivers of children with autism spectrum disorder. J Autism Dev Disord. 2017 May;47(5):1314-1322. [PMID: 28168677]

Kuhlthau KA, McDonnell E, Coury DL, Payakachat N, Macklin E. Associations of quality of life with health-related characteristics among children with autism. Autism. 2017 Jul 1:1362361317704420. [Epub ahead of print] [PMID: 28691502]

Leslie DL, Iskandarani K, Velott DL, Stein BD, Mandell DS, Agbese E, Dick AW. Medicaid waivers targeting children with autism spectrum disorder reduce the need for parents to stop working. Health Aff (Millwood). 2017 Feb 1;36(2):282-288. [PMID: 28167717]

Odom SL, Cox A, Sideris J, Hume KA, Hedges S, Kucharczyk S, Shaw E, Boyd BA, Reszka S, Neitzel J. Assessing quality of program environments for children and youth with autism: Autism Program Environment Rating Scale (APERS). J Autism Dev Disord. 2017 Nov 20. [Epub ahead of print] [PMID: 29159578]

Zuckerman KE, Lindly OJ, Reyes NM, Chavez AE, Macias K, Smith KN, Reynolds A. Disparities in diagnosis and treatment of autism in Latino and non-Latino white families. Pediatrics. 2017 May;139(5). pii: e20163010. [PMID: 28557734]

Question 6: How Can We Meet The Needs Of People With ASD as They Progress Into and Through Adulthood?

Bishop-Fitzpatrick L, Smith DaWalt L, Greenberg JS, Mailick MR. Participation in recreational activities buffers the impact of perceived stress on quality of life in adults with autism spectrum disorder. Autism Res. 2017 May;10(5):973-982. [PMID: 28244233]

Chan W, Smith LE, Hong J, Greenberg JS, Lounds Taylor J, Mailick MR. Factors associated with sustained community employment among adults with autism and co-occurring intellectual disability. Autism. 2017 Jul 1:1362361317703760. [Epub ahead of print] [PMID: 28691500]

Ditchman NM, Miller JL, Easton AB. Vocational rehabilitation service patterns: an application of social network analysis to examine employment outcomes of transition-age individuals with autism. Rehabil Counseling Bull. 2017 May 31. [available at:

Eack SM, Hogarty SS, Greenwald DP, Litschge MY, Porton SA, Mazefsky CA, Minshew NJ. Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial. Autism Res. 2017 Dec 29. [Epub ahead of print] [PMID: 29286586]

*Guan J, Li G. Injury mortality in individuals with autism. Am J Public Healt. 2017 May;107(5):791-793. [PMID: 28323463]

Liu G, Pearl AM, Kong L, Leslie DL, Murray MJ. A profile on emergency department utilization in adolescents and young adults with autism spectrum disorders. J Autism Dev Disord. 2017 Feb;47(2):347-358. [PMID: 27844247]

Mandy W, Clarke K, McKenner M, Strydom A, Crabtree J, Lai MC, Allison C, Baron-Cohen S, Skuse D. Assessing autism in adults: an evaluation of the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult). J Autism Dev Disord. 2017 Nov 7. [Epub ahead of print] [PMID: 29116420]

Nathenson RA, Zablotsky B. The transition to the adult health care system among youths with autism spectrum disorder. Psychiatr Serv. 2017 Jul 1;68(7):735-738 [PMID: 28292222]

Sasson NJ, Morrison KE. First impressions of adults with autism improve with diagnostic disclosure and increased autism knowledge of peers. Autism. 2017 Oct 1:1362361317729526. [Epub ahead of print] [PMID: 29039208]

Taylor JL, DaWalt LS. Brief report: postsecondary work and educational disruptions for youth on the autism spectrum. J Autism Dev Disord. 2017 Dec;47(12):4025-4031 [PMID: 28889215]

van Schalkwyk GI, Marin CE, Ortiz M, Rolison M, Qayyum Z, McPartland JC, Lebowitz ER, Volkmar FR, Silverman WK. Social media use, friendship quality, and the moderating role of anxiety in adolescents with autism spectrum disorder. J Autism Dev Disord. 2017 Sep;47(9):2805-2813. [PMID: 2861685]

Question 7: How Do We Continue To Build, Expand, and Enhance the Infrastructure System To Meet the Needs of the ASD Community?

*Durkin MS, Maenner MJ, Baio J, Christensen D, Daniels J, Fitzgerald R, Imm P, Lee LC, Schieve LA, Van Naarden Braun K, Wingate MS, Yeargin-Allsopp M. Autism spectrum disorder among US children (2002-2010): socioeconomic, racial, and ethnic disparities. Am J Public Health. 2017 Nov;107(11):1818-1826. [PMID: 28933930]

Hoffman K, Weisskopf MG, Roberts AL, Raz R, Hart JE, Lyall K, Hoffman EM, Laden F, Vieira VM. Geographic patterns of autism spectrum disorder among children of participants in Nurses’ Health Study II. Am J Epidemiol. 2017 Oct 1;186(7):834-842. [PMID: 28525627]

Joseph RM, O’Shea TM, Allred EN, Heeren T, Hirtz D, Paneth N, Leviton A, Kuban KC. Prevalence and associated features of autism spectrum disorder in extremely low gestational age newborns at age 10 years. Autism Res. 2017 Feb;10(2):224-232. [PMID: 27220677]

*Loomes R, Hull L, Mandy WPL. What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2017 Jun;56(6):466-474. [PMID: 28545751]

IACC LogoAbout the IACC

The Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating all activities concerning autism spectrum disorder (ASD) within the U.S. Department of Health and Human Services (HHS) and providing advice to the Secretary of HHS on issues related to autism. It was established by Congress under the Children’s Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed under the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2014.

Membership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, family members of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. This IACC membership is composed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by families and individuals affected by autism.

Under the CAA and subsequent authorizations, the IACC is required to (1) develop and annually update a strategic plan for ASD research, (2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.

Through these and other activities, the IACC provides guidance to HHS and partners with the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.

For more information about the IACC, see

Interagency Autism Coordinating Committee Member Roster


  • Joshua Gordon, M.D., Ph.D. Director National Institute of Mental Health National Institutes of Health Bethesda, MD

Federal Members

  • James F. Battey, M.D., Ph.D. Director National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda, MD
  • Diana W. Bianchi, M.D. Director Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda, MD
  • Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director National Institute of Environmental Health Sciences and National Toxicology Program National Institutes of Health Research Triangle Park, NC
  • Francis S. Collins, M.D., Ph.D. Director National Institutes of Health Bethesda, MD
  • Ruth Etzel, M.D., Ph.D. Director Office of Children’s Health Protection Environmental Protection Agency Washington, DC
  • Tiffany R. Farchione, M.D. Deputy Director Division of Psychiatry Products U.S. Food and Drug Administration Silver Spring, MD
  • Melissa L. Harris Acting Deputy Director Disabled and Elderly Health Programs Group Centers for Medicaid and CHIP Services Center for Medicare and Medicaid Services Baltimore, MD
  • Jennifer Johnson, Ed.D. (alternate) Deputy Director, Administration on Intellectual and Developmental Disabilities Administration for Community Living Washington, DC
  • Laura Kavanagh, M.P.P. Deputy Associate Administrator Maternal and Child Health Health Resources and Services Administration Rockville, MD
  • Walter J. Koroshetz, M.D. Director National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, MD
  • Laura Pincock, Pharm.D., M.P.H. Pharmacist Officer Agency for Healthcare Research and Quality Rockville, MD
  • Marcella Ronyak, Ph.D., L.C.S.W., C.D.P. Deputy Director Division of Behavioral Health Indian Health Service Headquarters Rockville, MD
  • Stuart K. Shapira, M.D., Ph.D. Associate Director and Chief Medical Officer National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta, GA
  • Melissa Spencer Deputy Commissioner Office of Disability Policy Social Security Administration Baltimore, MD
  • Larry Wexler, Ed.D. Director Research to Practice Division     Office of Special Education Programs U.S. Department of Education Washington, DC
  • Nicole Williams, Ph.D. Program Manager Congressionally Directed Medical Research Programs U.S. Department of Defense Frederick, MD

Public Members

  • David Amaral, Ph.D. Distinguished Professor Department of Psychiatry & Behavioral Science University of California, Davis (UC) Research Director UC Davis MIND Institute Sacramento, CA
  • James Ball, Ed.D., B.C.B.A.-D. President and CEO JB Autism Consulting Cranbury, NJ
  • Samantha Crane, J.D. Legal Director and Director of Public Policy Autistic Self Advocacy Network Washington, DC
  • Geraldine Dawson, Ph.D. Professor Department of Psychiatry and Behavioral Science Duke University School of Medicine Director Duke Center for Autism and Brain Development Durham, NC
  • David S. Mandell, Sc.D. Director Center for Mental Health Policy and Services Research Associate Professor Psychiatry and Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia, PA
  • Kevin Pelphrey, Ph.D. Carbonell Family Professor and Director Autism and Neurodevelopmental Disorders Institute George Washington University Children's National Medical Center Washington, DC
  • Edlyn Peña, Ph.D. Assistant Professor of Educational Leadership Director of Doctoral Studies California Lutheran University Thousand Oaks, CA
  • Louis Reichardt, Ph.D. Director Simons Foundation Autism Research Initiative New York, NY
  • Robert H. Ring, Ph.D. Chief Executive Officer Vencerx Therapeutics New York, NY
  • John Elder Robison Neurodiversity Scholar in Residence College of William and Mary Amherst, MA
  • Alison Tepper Singer, M.B.A. President Autism Science Foundation Scarsdale, NY
  • Julie Lounds Taylor, Ph.D. Assistant Professor of Pediatrics and Special Education Vanderbilt University Investigator Vanderbilt Kennedy Center Nashville, TN
OARC logo
6001 Executive Boulevard, Room 6182A, Bethesda, MD 20892
National Institute of Mental Health
National Institutes of Health

Office of Autism Research Coordination Staff List

  • Susan Daniels, Ph.D. Director
  • Oni Celestin, Ph.D. Health Science Policy Analyst
  • Rebecca Martin, M.P.H. Public Health Analyst
  • Angelice Mitrakas, B.A. Management Analyst
  • Karen Mowrer, Ph.D. Health Science Policy Analyst
  • Julianna Rava, M.P.H. Health Science Policy Analyst
  • Matthew Vilnit, B.S. Operations Coordinator
  • Jeffrey Wiegand, B.S. Web Development Manager

Cover Design
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Copyright Information
All material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.

Suggested Citation
Interagency Autism Coordinating Committee (IACC). 2017 IACC Summary of Advances in Autism Spectrum Disorder Research. April 2018. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website:


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