Summary of Advances
In Autism Spectrum Disorder Research
Full Listing of Nominated Articles (Selected Articles Appear in *Bold)
Question 1: How Can I Recognize The Signs Of ASD, and Why Is Early Detection So Important?
*Bosl WJ, Tager-Flusberg H, Nelson CA. EEG Analytics for Early Detection of Autism Spectrum Disorder: A data-driven approach. Sci Rep. 2018 May 1;8(1):6828. [PMID: 29717196]
*Egger HL, Dawson G, Hashemi J, Carpenter KLH, Espinosa S, Campbell K, Brotkin S, Schaich-Borg J, Qiu Q, Tepper M, Baker JP, Bloomfield RA, and Sapiro G. Automatic Emotion and Attention Analysis of Young Children at Home: A ResearchKit Autism Feasibility Study. npj Digital Medicine. 2018 Jun 1;1(20). http://www.nature.com/articles/s41746-018-0024-6
Hirai AH, Kogan MD, Kandasamy V, Reuland C, Bethell C. Prevalence and Variation of Developmental Screening and Surveillance in Early Childhood. JAMA Pediatr. 2018 Jul 9 [PMID: 29987317]
Ozonoff S, Young GS, Brian J, Charman T, Shephard E, Solish A, Zwaigenbaum L. Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. J Am Acad Child Adolesc Psychiatry. 2018 Nov;57(11):849-857.e2. [PMID: 30392626]
Sacrey LR, Zwaigenbaum L, Bryson S, Brian J, Smith IM, Roberts W, Szatmari P, Vaillancourt T, Roncadin C, Garon N. Parent and clinician agreement regarding early behavioral signs in 12- and 18-month-old infants at-risk of autism spectrum disorder. Autism Res. [PMID: 29356441]
*Wolff JJ, Dimian AF, Botteron KN, Dager SR, Elison JT, Estes AM, Hazlett HC, Schultz RT, Zwaigenbaum L, Piven J; IBIS Network. A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism. Child Psychol Psychiatry. 2018 Oct 23. [PMID: 30350375]
Question 2: What Is the Biology Underlying ASD?
*Avino TA, Barger N, Vargas MV, Carlson EL, Amaral DG, Bauman MD, Schumann CM. Neuron numbers increase in the human amygdala from birth to adulthood, but not in autism. Proc Natl Acad Sci USA. 2018 Apr 3;115(14):3710-3715. [PMID: 29559529]
*Deneault E, White SH, Rodrigues DC, Ross PJ, Faheem M, Zaslavsky K, Wang Z, Alexandrova R, Pellecchia G, Wei W, Piekna A, Kaur G, Howe JL, Kwan V, Thiruvahindrapuram B, Walker S, Lionel AC, Pasceri P, Merico D, Yuen RKC, Singh KK, Ellis J, Scherer SW. Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons. Stem Cell Reports. Nov 13;11(5):1211-1225. [PMID: 30392976]
Greenblatt EJ, Spradling AC. Fragile X mental retardation 1 gene enhances the translation of large autismrelated proteins. Science 2018 Aug 17;361(6403):709-712. [PMID: 30115809]
Handen BL, Mazefsky CA, Gabriels RL, Pedersen KA, Wallace M, Siegel M; Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC). Risk Factors for Self-injurious Behavior in an Inpatient Psychiatric Sample of Children with Autism Spectrum Disorder: A Naturalistic Observation Study. Dev Disord. 2018 Jan 24. [PMID: 29368233]
Jones KL, Pride MC, Edmiston E, Yang M, Silverman JL, Crawley JN, Van de Water J. Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism. Mol Psychiatry. 2018 Jun 28. [PMID: 29955164]
Jung H, Park H, Choi Y, Kang H, Lee E, Kweon H, Roh JD, Ellegood J, Choi W, Kang J, Rhim I, Choi SY, Bae M, Kim SG, Lee J, Chung C, Yoo T, Park H, Kim Y, Ha S, Um SM, Mo S, Kwon Y, Mah W, Bae YC, Kim H, Lerch JP, Paik SB, Kim E. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nat Neurosci. 2018 Sep;21(9):1218-1228. [PMID: 30104731]
Karalunas SL, Hawkey E, Gustafsson H, Miller M, Langhorst M, Cordova M, Fair D, Nigg JT. Overlapping and Distinct Cognitive Impairments in Attention-Deficit/Hyperactivity and Autism Spectrum Disorder without Intellectual Disability. J Abnorm Child Psychol. 2018 Nov;46(8):1705-1716. [PMID: 29450820]
*Qin L, Ma K, Wang ZJ, Hu Z, Matas E, Wei J, Yan Z. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nat Neurosci. 2018 Apr;21(4):564-575. [PMID: 29531362]
Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?
Andrews SV, Sheppard B, Windham GC, Schieve LA, Schendel DE, Croen LA, Chopra P, Alisch RS, Newschaffer CJ, Warren ST, Feinberg AP, Fallin MD, Ladd-Acosta C. Case-control meta-analysis of blood DNA methylation and autism spectrum disorder. Mol Autism. 2018 Jun 28;9:40. [PMID: 29988321]
*The Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). [PMID: 29930110]
*Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, PangT, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 Apr 20;360(6386):327-331. [PMID: 29674594]
Brown AS, Cheslack-Postava K, Rantakokko P, Kiviranta H, Hinkka-Yli-Salomäki S, McKeague IW, Surcel HM, Sourander A. Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort. Am J Psychiatry. 2018 Nov 1;175(11):1094-1101. [PMID: 30111184]
Chen S, Fragoza R, Klei L, Liu Y, Wang J, Roeder K, Devlin B, Yu H. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Nat Genet. 2018 Jul;50(7):1032-1040. [PMID: 29892012]
Curtin P, Austin C, Curtin A, Gennings C, Arora M; (for the Emergent Dynamical Systems Group), Tammimies K, Willfors C, Berggren S, Siper P, Rai D, Meyering K, Kolevzon A, Mollon J, David AS, Lewis G, Zammit S, Heilbrun L, Palmer RF, Wright RO, Bölte S, Reichenberg A. Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Sci Adv. 2018 May 30;4(5):eaat1293. [PMID: 29854952]
*Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group, Horvath S, Geschwind DH. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science. 2018 Feb 9;359(6376):693-697. [PMID: 29439242]
*Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018 De c 14;362(6420). [PMID: 30545856]
Janecka M, Kodesh A, Levine SZ, Lusskin SI, Viktorin A, Rahman R, Buxbaum JD, Schlessinger A, Sandin S, Reichenberg A. Association of Autism Spectrum Disorder With Prenatal Exposure to Medication Affecting Neurotransmitter Systems. JAMA Psychiatry. 2018 Dec 1;75(12):1217-1224. [PMID: 30383108]
Kalkbrenner AE, Windham GC, Zheng C, McConnell R, Lee NL, Schauer JJ, Thayer B, Pandey J, Volk HE. Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a U.S. Family-Based Study. Environ Health Perspect. 2018 Mar 12;126(3):037004. [PMID: 29553459]
Schieve LA, Tian LH, Drews-Botsch C, Windham GC, Newschaffer C, Daniels JL, Lee LC, Croen LA, Fallin MD. Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED). Autism Res. 2018 Jan;11(1):81-94. [PMID: 29164825]
*Short PJ, McRae JF, Gallone G, Sifrim A, Won H, Geschwind DH, Wright CF, Firth HV, FitzPatrick DR, Barrett JC, Hurles ME. De novo mutations in regulatory elements in neurodevelopmental disorders. Nature. 2018 Mar 29;555(7698):611-616. [PMID: 29562236]
Tabouy L, Getselter D, Ziv O, Karpuj M, Tabouy T, Lukic I, Maayouf R, Werbner N, Ben-Amram H, Nuriel-Ohayon M, Koren O, Elliott E. Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders. Brain Behav Immun. 2018 Oct;73:310-319. [PMID: 29787855]
Werling DM, Brand H, An JY, Stone MR, Zhu L, Glessner JT, Collins RL, Dong S, Layer RM, MarkenscoffPapadimitriou E, Farrell A, Schwartz GB, Wang HZ, Currall BB, Zhao X, Dea J, Duhn C, Erdman CA, Gilson MC, Yadav R, Handsaker RE, Kashin S, Klei L, Mandell JD, Nowakowski TJ, Liu Y, Pochareddy S, Smith L, Walker MF, Waterman MJ, He X, Kriegstein AR, Rubenstein JL, Sestan N, McCarroll SA, Neale BM, Coon H, Willsey AJ, Buxbaum JD, Daly MJ, State MW, Quinlan AR, Marth GT, Roeder K, Devlin B, Talkowski ME, Sanders SJ. An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. Nat Genet. 2018 May;50(5):727-736. [PMID: 29700473]
Question 4: Which Treatments and Interventions Will Help?
*Morgan L, Hooker JL, Sparapani N, Reinhardt VP, Schatschneider C, Wetherby AM. Cluster randomized trial of the classroom SCERTS intervention for elementary students with autism spectrum disorder. J Consult Clin Psychol. 2018 Jul;86(7):631-644. [PMID: 29939056]
*Nevill RE, Lecavalier L, Stratis EA. Meta-analysis of parent-mediated interventions for young children with autism spectrum disorder. Autism. 2018 Feb;22(2):84-98 [PMID: 29490483]
*Stedman A, Taylor B, Erard M, Peura C, Siegel M. Are Children Severely Affected by Autism Spectrum Disorder Underrepresented in Treatment Studies? An Analysis of the Literature. J Autism Dev Disord. 2018 Dec 10. [PMID: 30536112]
Question 5: What Kinds Of Services and Supports are Needed To Maximize Quality Of Life For People On The Autism Spectrum?
*Kennedy-Hendricks A, Epstein AJ, Mandell DS, Candon MK, Marcus SC, Xie M, Barry CL. Effects of State Autism Mandate Age Caps on Health Service Use and Spending Among Adolescents. J Am Acad Child Adolesc Psychiatry. 2018 Feb;57(2):125-131. [PMID: 29413145]
Rubenstein E, Daniels J, Schieve LA, Christensen DL, Van Naarden Braun K, Rice CE, Bakian AV, Durkin MS, Rosenberg SA, Kirby RS, Lee LC. Trends in Special Education Eligibility Among Children With Autism Spectrum Disorder, 2002-2010. Public Health Rep. 2018 Jan/Feb;133(1):85-92. [PMID: 29257937]
Waters CF, Amerine Dickens M, Thurston SW, Lu X, Smith T. Sustainability of Early Intensive Behavioral Intervention for Children With Autism Spectrum Disorder in a Community Setting. Behav Modif. 2018 Jul 1:145445518786463. [PMID: 30009626]
*Zerbo O, Modaressi S, Goddard K, Lewis E, Fireman BH, Daley MF, Irving SA, Jackson LA, Donahue JG, Qian L, Getahun D, DeStefano F, McNeil MM, Klein NP. Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings. JAMA Pediatr. 2018 Mar 26. [PMID: 29582071]
Zerbo O, Qian Y, Ray T, Sidney S, Rich S, Massolo M, Croen LA. Healthcare Service Utilization and Cost Among Adults with Autism Spectrum Disorders in a U.S. Integrated Healthcare System. Autism in Adulthood. Published online 1 Apr 2018. [http://doi.org/10.1089/aut.2018.0004]
Question 6: How Can We Meet The Needs Of People With ASD as They Progress Into and Through Adulthood?
*Bal VH, Kim SH, Fok M, Lord C. Autism spectrum disorder symptoms from ages 2 to 19 years: Implications for diagnosing adolescents and young adults. Autism Res. 2018 Aug 12. [PMID: 30101492]
*Davignon MN, Qian Y, Massolo M, Croen LA. Psychiatric and Medical Conditions in Transition-Aged Individuals With ASD. Pediatrics. 2018 Apr;141(Suppl 4):S335-S345. [PMID: 29610415]
*Dudley KM, Klinger MR, Meyer A, Powell P, Klinger LG. Understanding Service Usage and Needs for Adults with ASD: The Importance of Living Situation. J Autism Dev Disord. 2018 Aug 25. [PMID: 30145735]
Question 7: How Do We Continue To Build, Expand, and Enhance the Infrastructure System To Meet the Needs of the ASD Community?
*Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, Durkin MS, Imm P, Nikolaou L, Yeargin-Allsopp M, Lee LC, Harrington R, Lopez M, Fitzgerald RT, Hewitt A, Pettygrove S, Constantino JN, Vehorn A, Shenouda J, Hall-Lande J, Van Naarden Braun K, Dowling NF. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR Surveill Summ. 2018 Apr 27;67(6):1-23. [PMID: 29701730]
Kogan MD, Vladutiu CJ, Schieve LA, Ghandour RM, Blumberg SJ, Zablotsky B, Perrin JM, Shattuck P, Kuhlthau KA, Harwood RL, Lu MC. The Prevalence of Parent-Reported Autism Spectrum Disorder Among US Children. Pediatrics. 2018 Dec;142(6). [PMID: 30478241]
McDonnell CG, Boan AD, Bradley CC, Seay KD, Charles JM, Carpenter LA. Child maltreatment in autism spectrum disorder and intellectual disability: results from a population-based sample. J Child Psychol Psychiatry. 2018 Oct 19. [PMID: 30368827]
Schendel DE, Thorsteinsson E. Cumulative Incidence of Autism Into Adulthood for Birth Cohorts in Denmark, 1980-2012. JAMA. 2018 Nov 6;320(17):1811-1813. [PMID: 30398592]
About the IACC
The Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating all activities concerning autism spectrum disorder (ASD) within the U.S. Department of Health and Human Services (HHS) and providing advice to the Secretary of HHS on issues related to autism. It was established by Congress under the Children’s Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed under the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2014.
Membership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, family members of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. This IACC membership is composed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by families and individuals affected by autism.
Under the CAA and subsequent authorizations, the IACC is required to (1) develop and annually update a strategic plan for ASD research, (2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.
Through these and other activities, the IACC provides guidance to HHS and partners with the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.
For more information about the IACC, see https://iacc.hhs.gov.
Interagency Autism Coordinating Committee Member Roster
- Joshua Gordon, M.D., Ph.D. Director National Institute of Mental Health National Institutes of Health Bethesda, MD
- Melinda Baldwin, Ph.D. Child Welfare Program Specialist Children’s Bureau Administration on Children, Youth, and Families Administration for Children and Families Washington, DC
- Diana W. Bianchi, M.D. Director Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda, MD
- Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director National Institute of Environmental Health Sciences and National Toxicology Program National Institutes of Health Research Triangle Park, NC
- Francis S. Collins, M.D., Ph.D. Director National Institutes of Health Bethesda, MD
- Judith A. Cooper, Ph.D. Acting Director National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda, MD
- Elaine Cohen Hubal, Ph.D. (alternate) Senior Science Advisor Office of Research and Development National Exposure Research Laboratory Environmental Protection Agency Washington, DC
- Tiffany R. Farchione, M.D. Deputy Director Division of Psychiatry Products U.S. Food and Drug Administration Silver Spring, MD
- Melissa L. Harris Acting Deputy Director Disabled and Elderly Health Programs Group Centers for Medicaid and CHIP Services Center for Medicare and Medicaid Services Baltimore, MD
- Jennifer Johnson, Ed.D. Deputy Director, Administration on Intellectual and Developmental Disabilities Administration for Community Living Washington, DC
- Laura Kavanagh, M.P.P. Deputy Associate Administrator Maternal and Child Health Health Resources and Services Administration Rockville, MD
- Walter J. Koroshetz, M.D. Director National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, MD
- Laura Pincock, Pharm.D., M.P.H. Pharmacist Officer Agency for Healthcare Research and Quality Rockville, MD
- Marcella Ronyak, Ph.D., L.C.S.W., C.D.P. Director Division of Clinical & Community Services Indian Health Service Headquarters Rockville, MD
- Stuart K. Shapira, M.D., Ph.D. Associate Director and Chief Medical Officer National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta, GA
- Melissa Spencer Deputy Commissioner Office of Disability Policy Social Security Administration Baltimore, MD
- Larry Wexler, Ed.D. Director Research to Practice Office of Special Education Programs U.S. Department of Education Washington, DC
- Nicole Williams, Ph.D. Program Manager Congressionally Directed Medical Research Programs U.S. Department of Defense Frederick, MD
- David Amaral, Ph.D. Distinguished Professor Department of Psychiatry & Behavioral Science University of California, Davis (UC) Research Director UC Davis MIND Institute Sacramento, CA
- James Ball, Ed.D., B.C.B.A.-D. President and CEO JB Autism Consulting Cranbury, NJ
- Samantha Crane, J.D. Legal Director and Director of Public Policy Autistic Self Advocacy Network Washington, DC
- Geraldine Dawson, Ph.D. Professor Department of Psychiatry and Behavioral Science Duke University School of Medicine Director Duke Center for Autism and Brain Development Durham, NC
- David S. Mandell, Sc.D. Director Center for Mental Health Policy and Services Research Associate Professor Psychiatry and Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia, PA
- Kevin Pelphrey, Ph.D. Harrison-Wood Jefferson Scholars Foundation Professor of Neurology & Professor Curry School of Education University of Virginia
- Edlyn Peña, Ph.D. Assistant Professor of Educational Leadership Director of Doctoral Studies California Lutheran University Thousand Oaks, CA
- Louis Reichardt, Ph.D. Director Simons Foundation Autism Research Initiative New York, NY
- Robert H. Ring, Ph.D. Chief Executive Officer Kaerus Bioscience Newtown, PA
- John Elder Robison Neurodiversity Scholar in Residence College of William and Mary Amherst, MA
- Alison Tepper Singer, M.B.A. President Autism Science Foundation Scarsdale, NY
- Julie Lounds Taylor, Ph.D. Associate Professor of Pediatrics Vanderbilt University Investigator Vanderbilt Kennedy Center Nashville, TN
Office of Autism Research Coordination Staff List
- Susan Daniels, Ph.D. Director
- Oni Celestin, Ph.D. Health Science Policy Analyst
- Rebecca Martin, M.P.H. Public Health Analyst
- Angelice Mitrakas, B.A. Management Analyst
- Julianna Rava, M.P.H. Health Science Policy Analyst
- Matthew Vilnit, B.S. Operations Coordinator
- Jeffrey Wiegand, B.S. Web Development Manager
NIH Medical Arts Branch
This report is a Work of the United States Government. A suggested citation follows.
Interagency Autism Coordinating Committee (IACC). 2018 IACC Summary of Advances in Autism Spectrum Disorder Research. April 2019. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: https://iacc.hhs.gov/publications/summary-of-advances/2018/.