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Summary of Advances Cover 2018

Summary of Advances

In Autism Spectrum Disorder Research


Articles Selected for the 2018 Summary of Advances

Question 1: How Can I Recognize The Signs Of ASD, and Why Is Early Detection So Important?

  • EEG analytics for early detection of autism spectrum disorder: a data-driven approach
  • Automatic emotion and attention analysis of young children at home: a ResearchKit autism feasibility study
  • A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism

Question 2: What Is the Biology Underlying ASD?

  • Neuron numbers increase in the human amygdala from birth to adulthood, but not in autism
  • Complete disruption of autism-susceptibility genes by gene editing predominantly reduces functional connectivity of isogenic human neurons
  • Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?

  • Analysis of shared heritability in common disorders of the brain
  • Paternally inherited cis-regulatory structural variants are associated with autism
  • Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
  • Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
  • De novo mutations in regulatory elements in neurodevelopmental disorders

Question 4: Which Treatments and Interventions Will Help?

  • Cluster randomized trial of the classroom SCERTS intervention for elementary students with autism spectrum disorder
  • Meta-analysis of parent-mediated interventions for young children with autism spectrum disorder
  • Are children severely affected by autism spectrum disorder underrepresented in treatment studies? An analysis of the literature

Question 5: What Kinds Of Services and Supports are Needed To Maximize Quality Of Life For People On The Autism Spectrum?

  • Effects of state autism mandate age caps on health service use and spending among adolescents
  • Vaccination patterns in children after autism spectrum disorder diagnosis and in their younger siblings

Question 6: How Can We Meet The Needs Of People With ASD as They Progress Into and Through Adulthood?

  • Autism spectrum disorder symptoms from ages 2 to 19 years: implications for diagnosing adolescents and young adults
  • Psychiatric and medical conditions in transition-aged Individuals with ASD
  • Understanding service usage and needs for adults with ASD: the importance of living situation

Question 7: How Do We Continue To Build, Expand, and Enhance the Infrastructure System To Meet the Needs of the ASD Community?

  • Prevalence of autism spectrum disorder among children aged 8 years — Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2014.

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