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Summary of Advances Cover 2019

Summary of Advances

In Autism Spectrum Disorder Research

2019

Appendices

Articles Selected for the 2019 Summary Of Advances


Question 1: How Can I Recognize the Signs of ASD, and Why is Early Detection So Important?

Guthrie W, Wallis K, Bennett A, Brooks E, Dudley J, Gerdes M, Pandey J, Levy SE, Schultz RT, Miller JS. Accuracy of Autism Screening in a Large Pediatric Network. Pediatrics. 2019 Oct;144(4). pii: e20183963. [PMID: 31562252]

Pierce K, Gazestani VH, Bacon E, Barnes CC, Cha D, Nalabolu S, Lopez L, Moore A, Pence-Stophaeros S, Courchesne E. Evaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months. JAMA Pediatr. 2019 Jun 1;173(6):578-587. [PMID: 31034004]

Wiggins LD, Durkin M, Esler A, Lee LC, Zahorodny W, Rice C, Yeargin-Allsopp M, Dowling NF, Hall-Lande J, Morrier MJ, Christensen D, Shenouda J, Baio J. Disparities in Documented Diagnoses of Autism Spectrum Disorder Based on Demographic, Individual, and Service Factors. Autism Res. 2020 Mar;13(3):464-473. [PMID: 31868321]


Question 2: What Is the Biology Underlying ASD?

Bal VH, Fok M, Lord C, Smith IM, Mirenda P, Szatmari P, Vaillancourt T, Volden J, Waddell C, Zwaigenbaum L, Bennett T, Duku E, Elsabbagh M, Georgiades S, Ungar WJ, Zaidman-Zait A. Predictors of Longer-Term Development of Expressive Language in Two Independent Longitudinal Cohorts of Language-Delayed Preschoolers with Autism Spectrum Disorder. J Child Psychol Psychiatry. 2019 Aug 19. [PMID: 31429087]


Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?

Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H, Gissler M, Buxbaum JD, Wong K, Schendel D, Kodesh A, Breshnahan M, Levine SZ, Parner ET, Hansen SN, Hultman C, Reichenberg A, Sandin S. Association of Genetic and Environmental Factors with Autism in a 5-Country Cohort. JAMA Psychiatry. 2019 Jul 17. [PMID: 31314057]

Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD. Identification of Common Genetic Risk Variants for Autism Spectrum Disorder. Nat Genet. 2019 Mar;51(3):431-444. [PMID: 30804558]

Hviid A, Hansen JV, Frisch M, Melbye M. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Ann Intern Med. 2019 Apr 16;170(8):513-520. [PMID: 30831578]

McGuinn LA, Windham GC, Messer LC, Di Q, Schwartz J, Croen LA, Moody EJ, Rappold AG, Richardson DB, Neas LM, Gammon MD, Schieve LA, Daniels JL. Air Pollution, Neighborhood Deprivation, and Autism Spectrum Disorder in the Study to Explore Early Development. Environmental Epidemiology. 2019 October;3(5):e067. [https://doi.org/10.1097/EE9.0000000000000067]

Schmidt RJ, Iosif AM, Guerrero Angel E, Ozonoff S. Association of Maternal Prenatal Vitamin Use with Risk for Autism Spectrum Disorder Recurrence in Young Siblings. JAMA Psychiatry. 2019 Apr 1;76(4):391-398. [PMID: 30810722]


Question 4: Which Treatments and Interventions Will Help?

Nahmias AS, Pellecchia M, Stahmer AC, Mandell DS. Effectiveness of Community-Based Early Intervention for Children with Autism Spectrum Disorder: A Meta-Analysis. Child Psychol Psychiatry. 2019 Nov;60(11):1200-1209. [PMID: 31206690]

Rogers SJ, Estes A, Lord C, Munson J, Rocha M, Winter J, Greenson J, Colombi C, Dawson G, Vismara LA, Sugar CA, Hellemann G, Whelan F, Talbott M. A Multisite Randomized Controlled Two-Phase Trial of the Early Start Denver Model Compared to Treatment as Usual. J Am Acad Child Adolesc Psychiatry. 2019 Sep;58(9):853-865. [PMID: 30768394]

Voss C, Schwartz J, Daniels J, Kline A, Haber N, Washington P, Tariq Q, Robinson TN, Desai M, Phillips JM, Feinstein C, Winograd T, Wall DP. Effect of Wearable Digital Intervention for Improving Socialization in Children with Autism Spectrum Disorder: A Randomized Clinical Trial. JAMA Pediatr. 2019 May 1;173(5): 446-454. [PMID: 30907929]


Question 5: What Kinds Of Services and Supports are Needed to Maximize Quality of Life for People on the Autism Spectrum?

Brookman-Frazee L, Roesch S, Chlebowski C, Baker-Ericzen M, Ganger W. Brookman-Frazee L, Roesch S, Chlebowski C, Baker-Ericzen M, Ganger W. Effectiveness of Training Therapists to Deliver an Individualized Mental Health Intervention for Children with ASD in Publicly Funded Mental Health Services: A Cluster Randomized Clinical Trial. JAMA Psychiatry. 2019 Jun 1;76(6):574-583. [PMID: 30840040]

LaClair M, Mandell DS, Dick AW, Iskandarani K, Stein BD, Leslie DL. The Effect of Medicaid Waivers on Ameliorating Racial/Ethnic Disparities Among Children with Autism. Health Serv Res. 2019 Aug;54(4):912-919. [PMID: 31132161]


Question 6: How Can We Meet the Needs of People With ASD as They Progress Into and Through Adulthood?

Kirby AV, Bakian AV, Zhang Y, Bilder DA, Keeshin BR, Coon H. A 20-Year Study of Suicide Death in a Statewide Autism Population. Autism Res. 2019 Apr;12(4):658-666. [PMID: 30663277]

Laxman DJ, Taylor JL, DaWalt LS, Greenberg JS, Mailick MR. Loss in Services Precedes High School Exit for Teens with Autism Spectrum Disorder: A Longitudinal Study. Autism Res. 2019 Jun;12(6):911-921. [PMID: 31033222]

Rast JE, Roux AM, Shattuck PT. Use of Vocational Rehabilitation Supports for Postsecondary Education Among Transition-Age Youth on the Autism Spectrum. Autism Dev Disord. 2019 Mar 8. [PMID: 30848406]

Wehman P, Schall C, McDonough J, Sima A, Brooke A, Ham W, Whittenburg H, Brooke V, Avellone L, Riehle E. Competitive Employment for Transition-Aged Youth with Significant Impact from Autism: A Multi-Site Randomized Clinical Trial. J Autism Dev Disord. 2019 Mar 1. [PMID: 30825082]


Question 7: How Do We Continue to Build, Expand, and Enhance the Infrastructure System to Meet the Needs of the ASD Community?

Christensen DL, Maenner MJ, Bilder D, Constantino JN, Daniels J, Durkin MS, Fitzgerald RT, Kurzius-Spencer M, Pettygrove SD, Robinson C, Shenouda J, White T, Zahorodny W, Pazol K, Dietz P. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years—Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014. MMWR Surveill Summ. 2019 Apr 12;68(2):1-19. [PMID: 30973853]

Russell G, Mandy W, Elliott D, White R, Pittwood T, Ford T. Selection Bias on Intellectual Ability in Autism Research: A Cross-Sectional Review and Meta-Analysis. Mol Autism. 2019 Mar 1;10:9. [PMID: 30867896]


Full Listing of Nominated Articles (Selected Articles Start With *)


Question 1: How Can I Recognize the Signs of ASD, and Why is Early Detection So Important?

*Guthrie W, Wallis K, Bennett A, Brooks E, Dudley J, Gerdes M, Pandey J, Levy SE, Schultz RT, Miller JS. Accuracy of Autism Screening in a Large Pediatric Network. Pediatrics. 2019 Oct;144(4). pii: e20183963. [PMID: 31562252]

*Pierce K, Gazestani VH, Bacon E, Barnes CC, Cha D, Nalabolu S, Lopez L, Moore A, Pence-Stophaeros S, Courchesne E. Evaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months. JAMA Pediatr. 2019 Jun 1;173(6):578-587. [PMID: 31034004]

Rødgaard EM, Jensen K, Vergnes JN, Soulières I, Mottron L. Temporal Changes in Effect Sizes of Studies Comparing Individuals With and Without Autism: A Meta-Analysis. JAMA Psychiatry. 2019 Aug 21. [PMID: 31433441]

Shapira SK, Tian LH, Aylsworth AS, Elias ER, Hoover-Fong JE, Meeks NJL, Souders MC, Tsai AC, Zackai EH, Alexander AA, Yeargin-Allsopp M, Schieve LA. A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development. J Autism Dev Disord. 2019 May;49(5):2184-2202. [PMID: 30783897]

*Wiggins LD, Durkin M, Esler A, Lee LC, Zahorodny W, Rice C, Yeargin-Allsopp M, Dowling NF, Hall-Lande J, Morrier MJ, Christensen D, Shenouda J, Baio J. Disparities in Documented Diagnoses of Autism Spectrum Disorder Based on Demographic, Individual, and Service Factors. Autism Res. 2020 Mar;13(3):464-473. [PMID: 31868321]

Wiggins LD, Rice CE, Barger B, Soke GN, Lee LC, Moody E, Edmondson-Pretzel R, Levy SE. DSM-5 Criteria for Autism Spectrum Disorder Maximizes Diagnostic Sensitivity and Specificity in Preschool Children. Soc Psychiatry Psychiatr Epidemiol. 2019 Jun;54(6):693-701. [PMID: 30850887]


Question 2: What is the Biology Underlying ASD?

Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, Williams M, Heussler H, de Vrij FMS, Mientjes EJ, van Woerden GM, Kushner SA, Distel B, Elgersma Y. Loss of Nuclear UBE3A Causes Electrophysiological and Behavioral Deficits in Mice And is Associated with Angelman Syndrome. Nat Neurosci. 2019 Aug;22(8):1235-1247. [PMID: 31235931]

*Bal VH, Fok M, Lord C, Smith IM, Mirenda P, Szatmari P, Vaillancourt T, Volden J, Waddell C, Zwaigenbaum L, Bennett T, Duku E, Elsabbagh M, Georgiades S, Ungar WJ, Zaidman-Zait A. Predictors of Longer-Term Development of Expressive Language in Two Independent Longitudinal Cohorts of Language-Delayed Preschoolers with Autism Spectrum Disorder. J Child Psychol Psychiatry. 2019 Aug 19. [PMID: 31429087]

Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L. Structure and Mechanism of the Cation-Chloride Cotransporter NKCC1. Nature. 2019 Aug;572(7770):488-492. [PMID: 31367042]

Fröhlich H, Kollmeyer ML, Linz VC, Stuhlinger M, Groneberg D, Reigl A, Zizer E, Friebe A, Niesler B, Rappold G. Gastrointestinal Dysfunction in Autism Displayed by Altered Motility and Achalasia in Foxp1+/- Mice. Proc Natl Acad Sci. U S A. 2019 Oct 29;116(44):22237-22245. [PMID: 31611379]

Ingiosi A, Schoch H, Wintler TP, Singletary KG, Righelli D, Roser L, Medina E, Risso D, Frank MG, Peixoto L. Shank3 Modulates Sleep and Expression of Circadian Transcription Factors. eLife. 2019 Apr 11;8. pii: e42819. [PMID: 30973326]

Pagani M, Bertero A, Liska A, Galbusera A, Sabbioni M, Barsotti N, Colenbier N, Marinazzo D, Scattoni ML, Pasqualetti M, Gozzi A. Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity. J Neurosci. 2019 Jul 3;39(27):5299-5310. [PMID: 31061091]

Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick NG, Agnello E, O'Connell R, Stratton MM, Yasuda R, Hayashi Y. Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP. Neuron. 2019 Jun 19;102(6):1199-1210.e6. [PMID: 31078368]

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH. Pathological Priming Causes Developmental Gene Network Heterochronicity in Autistic Subject-Derived Neurons. Nat Neurosci. 2019 Feb;22(2):243-255. [PMID: 30617258]

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, Moradian A, Borenstein E, Jansson JK, Knight R, Metz TO, Lois C, Geschwind DH, Krajmalnik-Brown R, Mazmanian SK. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 2019 May 30;177(6):1600-1618.e17. [PMID: 31150625]

Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR. Single-Cell Genomics Identifies Cell Type-Specific Molecular Changes in Autism. Science. 2019 May 17; 364(6441):685-689. [PMID: 31097668]


Question 3: What Causes ASD, and Can Disabling Aspects of ASD be Prevented or Preempted?

Al-Haddad BJS, Jacobsson B, Chabra S, Modzelewska D, Olson EM, Bernier R, Enquobahrie DA, Hagberg H, Östling S, Rajagopal L, Adams Waldorf KM, Sengpiel V. Long-Term Risk of Neuropsychiatric Disease After Exposure to Infection In Utero. JAMA Psychiatry. 2019 Jun 1;76(6):594-602. [PMID: 30840048]

*Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H, Gissler M, Buxbaum JD, Wong K, Schendel D, Kodesh A, Breshnahan M, Levine SZ, Parner ET, Hansen SN, Hultman C, Reichenberg A, Sandin S. Association of Genetic and Environmental Factors with Autism in a 5-Country Cohort. JAMA Psychiatry. 2019 Jul 17. [PMID: 31314057]

Breuss MW, Antaki D, George RD, Kleiber M, James KN, Ball LL, Hong O, Mitra I, Yang X, Wirth SA, Gu J, Garcia CAB, Gujral M, Brandler WM, Musaev D, Nguyen A, McEvoy-Venneri J, Knox R, Sticca E, Botello MCC, Uribe Fenner J, Pérez MC, Arranz M, Moffitt AB, Wang Z, Hervás A, Devinsky O, Gymrek M, Sebat J, Gleeson JG. Autism Risk in Offspring Can Be Assessed through Quantification of Male Sperm Mosaicism. Nat Med. 2020 Jan;26(1):143-150. [PMID: 31873310]

Castelbaum L, Sylvester CM, Zhang Y, Yu Q, Constantino JN. On the Nature of Monozygotic Twin Concordance and Discordance for Autistic Trait Severity: A Quantitative Analysis. Behav Genet. 2019 Dec 18. [PMID: 31853901]

Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric Disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11. [PMID: 31835028]

D'Abate L, Walker S, Yuen RKC, Tammimies K, Buchanan JA, Davies RW, Thiruvahindrapuram B, Wei J, Brian J, Bryson SE, Dobkins K, Howe J, Landa R, Leef J, Messinger D, Ozonoff S, Smith IM, Stone WL, Warren ZE, Young G, Zwaigenbaum L, Scherer SW. Predictive Impact of Rare Genomic Copy Number Variations in Siblings of Individuals with Autism Spectrum Disorders. Nat Commun. 2019 Dec 5;10(1):5519 [PMID: 31801954]

*Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD. Identification of Common Genetic Risk Variants for Autism Spectrum Disorder. Nat Genet. 2019 Mar;51(3):431-444. [PMID: 30804558]

*Hviid A, Hansen JV, Frisch M, Melbye M. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Ann Intern Med. 2019 Apr 16;170(8):513-520. [PMID: 30831578]

Jo H, Eckel SP, Wang X, Chen JC, Cockburn M, Martinez MP, Chow T, Molshatzki N, Lurmann FW, Funk WE, Xiang AH, McConnell R. Sex-Specific Associations of Autism Spectrum Disorder with Residential Air Pollution Exposure in a Large Southern California Pregnancy Cohort. Environ Pollut. 2019 Nov;254(Pt A):113010. [PMID: 31554142]

*McGuinn LA, Windham GC, Messer LC, Di Q, Schwartz J, Croen LA, Moody EJ, Rappold AG, Richardson DB, Neas LM, Gammon MD, Schieve LA, Daniels JL. Air Pollution, Neighborhood Deprivation, and Autism Spectrum Disorder in the Study to Explore Early Development. Environmental Epidemiology. 2019 October;3(5):e067. [https://doi.org/10.1097/EE9.0000000000000067]

*Schmidt RJ, Iosif AM, Guerrero Angel E, Ozonoff S. Association of Maternal Prenatal Vitamin Use with Risk for Autism Spectrum Disorder Recurrence in Young Siblings. JAMA Psychiatry. 2019 Apr 1;76(4):391-398. [PMID: 30810722]

Septier M, Peyre H, Amsellem F, Beggiato A, Maruani A, Poumeyreau M, Amestoy A, Scheid I, Gaman A, Bolognani F, Honey G, Bouquet C, Ly-Le Moal M, Bouvard M, Leboyer M, Bourgeron T, Delorme R. Increased Risk of ADHD in Families with ASD. Eur Child Adolesc Psychiatry. 2019 Feb;28(2):281-288. [PMID: 30267210]

Zhou J, Park CY, Theesfeld CL, Wong AK, Yuan Y, Scheckel C, Fak JJ, Funk J, Yao K, Tajima Y, Packer A, Darnell RB, Troyanskaya OG. Whole-Genome Deep-Learning Analysis Identifies Contribution of Noncoding Mutations to Autism Risk. Nat Genet. 2019 Jun;51(6):973-980. [PMID: 31133750]


Question 4: Which Treatments and Interventions Will Help?

*Nahmias AS, Pellecchia M, Stahmer AC, Mandell DS. Effectiveness of Community-Based Early Intervention for Children with Autism Spectrum Disorder: A Meta-Analysis. Child Psychol Psychiatry. 2019 Nov;60(11):1200-1209. [PMID: 31206690]

*Rogers SJ, Estes A, Lord C, Munson J, Rocha M, Winter J, Greenson J, Colombi C, Dawson G, Vismara LA, Sugar CA, Hellemann G, Whelan F, Talbott M. A Multisite Randomized Controlled Two-Phase Trial of the Early Start Denver Model Compared to Treatment as Usual. J Am Acad Child Adolesc Psychiatry. 2019 Sep;58(9):853-865. [PMID: 30768394]

Sam AM, Cox AW, Savage MN, Waters V, Odom SL. Disseminating Information on Evidence-Based Practices for Children and Youth with Autism Spectrum Disorder: AFIRM. J Autism Dev Disord. 2019 Feb 28. [PMID: 30820727]

Tang X, Drotar J, Li K, Clairmont CD, Brumm AS, Sullins AJ, Wu H, Liu XS, Wang J, Gray NS, Sur M, Jaenisch R. Pharmacological Enhancement of KCC2 Gene Expression Exerts Therapeutic Effects on Human Rett Syndrome Neurons and Mecp2 Mutant Mice. Sci Transl Med. 2019 Jul 31;11(503). pii: eaau0164. [PMID: 31366578]

*Voss C, Schwartz J, Daniels J, Kline A, Haber N, Washington P, Tariq Q, Robinson TN, Desai M, Phillips JM, Feinstein C, Winograd T, Wall DP. Effect of Wearable Digital Intervention for Improving Socialization in Children with Autism Spectrum Disorder: A Randomized Clinical Trial. JAMA Pediatr. 2019 May 1;173(5): 446-454. [PMID: 30907929]


Question 5: What Kinds Of Services and Supports are Needed To Maximize Quality of Life for People on the Autism Spectrum?

Barry CL, Kennedy-Hendricks A, Mandell D, Epstein AJ, Candon M, Eisenberg M. State Mandate Laws for Autism Coverage and High-Deductible Health Plans. Pediatrics. 2019 Jun;143(6). [PMID: 31092588]

*Brookman-Frazee L, Roesch S, Chlebowski C, Baker-Ericzen M, Ganger W. Brookman-Frazee L, Roesch S, Chlebowski C, Baker-Ericzen M, Ganger W. Effectiveness of Training Therapists to Deliver an Individualized Mental Health Intervention for Children with ASD in Publicly Funded Mental Health Services: A Cluster Randomized Clinical Trial. JAMA Psychiatry. 2019 Jun 1;76(6):574-583. [PMID: 30840040]

*LaClair M, Mandell DS, Dick AW, Iskandarani K, Stein BD, Leslie DL. The Effect of Medicaid Waivers on Ameliorating Racial/Ethnic Disparities Among Children with Autism. Health Serv Res. 2019 Aug;54(4):912-919. [PMID: 31132161]

Monz BU, Houghton R, Law K, Loss G. Treatment Patterns in Children with Autism in the United States. Autism Res. 2019 Mar;12(3):517-526. [PMID: 30629336]


Question 6: How Can We Meet The Needs of People With ASD as They Progress Into and Through Adulthood?

*Kirby AV, Bakian AV, Zhang Y, Bilder DA, Keeshin BR, Coon H. A 20-Year Study of Suicide Death in a Statewide Autism Population. Autism Res. 2019 Apr;12(4):658-666. [PMID: 30663277]

*Laxman DJ, Taylor JL, DaWalt LS, Greenberg JS, Mailick MR. Loss in Services Precedes High School Exit for Teens with Autism Spectrum Disorder: A Longitudinal Study. Autism Res. 2019 Jun;12(6):911-921. [PMID: 31033222]

*Rast JE, Roux AM, Shattuck PT. Use of Vocational Rehabilitation Supports for Postsecondary Education Among Transition-Age Youth on the Autism Spectrum. J Autism Dev Disord. 2019 Mar 8. [PMID: 30848406]

*Wehman P, Schall C, McDonough J, Sima A, Brooke A, Ham W, Whittenburg H, Brooke V, Avellone L, Riehle E. Competitive Employment for Transition-Aged Youth with Significant Impact from Autism: A Multi-Site Randomized Clinical Trial. J Autism Dev Disord. 2019 Mar 1. [PMID: 30825082]


Question 7: How Do We Continue to Build, Expand, and Enhance the Infrastructure System to Meet the Needs of the ASD Community?

*Christensen DL, Maenner MJ, Bilder D, Constantino JN, Daniels J, Durkin MS, Fitzgerald RT, Kurzius-Spencer M, Pettygrove SD, Robinson C, Shenouda J, White T, Zahorodny W, Pazol K, Dietz P. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 4 Years—Early Autism and Developmental Disabilities Monitoring Network, Seven Sites, United States, 2010, 2012, and 2014. MMWR Surveill Summ. 2019 Apr 12;68(2):1-19. [PMID: 30973853]

*Russell G, Mandy W, Elliott D, White R, Pittwood T, Ford T. Selection Bias on Intellectual Ability in Autism Research: A Cross-Sectional Review and Meta-Analysis. Mol Autism. 2019 Mar 1;10:9. [PMID: 30867896]


IACC LogoAbout the IACC

The Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating Federal activities concerning autism spectrum disorder (ASD) and providing advice to the Secretary of Health and Human Services (HHS) on issues related to autism. The Committee was established by Congress under the Children's Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed most recently under the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2019.

Membership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, family members of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. The IACC membership is composed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by individuals and families affected by autism.

Under the CAA and subsequent reauthorizations, the IACC is required to (1) develop and annually update a strategic plan for ASD research, (2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.

Through these and other activities, the IACC provides guidance to HHS and partners with other Federal departments, Federal agencies, research and advocacy organizations, and the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.

For more information about the IACC, see https://iacc.hhs.gov.


Interagency Autism Coordinating Committee Member Roster


Chair

  • Joshua Gordon, M.D., Ph.D. Director National Institute of Mental Health National Institutes of Health Bethesda, MD

Federal Members

  • Melinda Baldwin, Ph.D. Child Welfare Program Specialist Children’s Bureau Administration on Children, Youth, and Families Administration for Children and Families Washington, DC
  • Diana W. Bianchi, M.D. Director Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda, MD
  • Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director National Institute of Environmental Health Sciences and National Toxicology Program National Institutes of Health Research Triangle Park, NC
  • Francis S. Collins, M.D., Ph.D. Director National Institutes of Health Bethesda, MD
  • Judith A. Cooper, Ph.D. Deputy Director National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda, MD
  • Elaine Cohen Hubal, Ph.D. (alternate) Senior Science Advisor Office of Research and Development National Exposure Research Laboratory Environmental Protection Agency Washington, DC
  • Tiffany R. Farchione, M.D. Deputy Director Division of Psychiatry Products U.S. Food and Drug Administration Silver Spring, MD
  • Melissa L. Harris Acting Deputy Director Disabled and Elderly Health Programs Group Centers for Medicaid and CHIP Services Center for Medicare and Medicaid Services Baltimore, MD
  • Jennifer Johnson, Ed.D. Deputy Director, Administration on Intellectual and Developmental Disabilities Administration for Community Living Washington, DC
  • Laura Kavanagh, M.P.P. Deputy Associate Administrator Maternal and Child Health Bureau Health Resources and Services Administration Rockville, MD
  • Walter J. Koroshetz, M.D. Director National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, MD
  • Laura Pincock, Pharm.D., M.P.H. Pharmacist Officer Agency for Healthcare Research and Quality Rockville, MD
  • Marcella Ronyak, Ph.D., L.C.S.W., C.D.P. Director Division of Clinical & Community Services Indian Health Service Headquarters Rockville, MD
  • Stuart K. Shapira, M.D., Ph.D. Associate Director for Science and Chief Medical Officer National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta, GA
  • Cheryl Williams Director Office of Medical Policy Office of Disability Policy Social Security Administration Baltimore, MD
  • Larry Wexler, Ed.D. Director Research to Practice      Office of Special Education Programs U.S. Department of Education Washington, DC
  • Nicole Williams, Ph.D. Program Manager Congressionally Directed Medical Research Programs U.S. Department of Defense Frederick, MD

Public Members

  • David Amaral, Ph.D. Distinguished Professor Department of Psychiatry & Behavioral Science University of California, Davis (UC) Research Director UC Davis MIND Institute Sacramento, CA
  • James Ball, Ed.D., B.C.B.A.-D. President and CEO JB Autism Consulting Cranbury, NJ
  • Samantha Crane, J.D. Legal Director and Director of Public Policy Autistic Self Advocacy Network Washington, DC
  • Geraldine Dawson, Ph.D. Professor Department of Psychiatry and Behavioral Science Duke University School of Medicine Director Duke Center for Autism and Brain Development Durham, NC
  • David S. Mandell, Sc.D. Director Center for Mental Health Policy and Services Research Associate Professor Psychiatry and Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia, PA
  • Kevin Pelphrey, Ph.D. Harrison-Wood Jefferson Scholars Foundation Professor of Neurology & Professor Curry School of Education University of Virginia
  • Edlyn Peña, Ph.D. Assistant Professor of Educational Leadership Director of Doctoral Studies California Lutheran University Thousand Oaks, CA
  • Louis Reichardt, Ph.D. Director Simons Foundation Autism Research Initiative New York, NY
  • Robert H. Ring, Ph.D. Chief Executive Officer Kaerus Bioscience Newtown, PA
  • John Elder Robison Neurodiversity Scholar in Residence College of William and Mary Amherst, MA
  • Alison Tepper Singer, M.B.A. President Autism Science Foundation Scarsdale, NY
  • Julie Lounds Taylor, Ph.D. Assistant Professor of Pediatrics Investigator Vanderbilt Kennedy Center Vanderbilt University Medical Center Nashville, TN
OARC logo
6001 Executive Boulevard, Room 7215, Bethesda, MD 20892
National Institute of Mental Health
National Institutes of Health
Email: IACCPublicInquiries@mail.nih.gov
Website: https://iacc.hhs.gov

Office of Autism Research Coordination Staff List


  • Susan Daniels, Ph.D. Director
  • Oni Celestin, Ph.D. Health Science Policy Analyst
  • Katrina Ferrara, Ph.D. Health Science Policy Analyst
  • Rebecca Martin, M.P.H. Public Health Analyst
  • Angelice Mitrakas, B.A. Management Analyst
  • Julianna Rava, M.P.H. Health Science Policy Analyst
  • Matthew Vilnit, B.S. Operations Coordinator
  • Jeffrey Wiegand, B.S. Web Development Manager

Cover Design
NIH Medical Arts Branch

Copyright Information
All material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.

Suggested Citation
Interagency Autism Coordinating Committee (IACC). 2019 IACC Summary of Advances in Autism Spectrum Disorder Research. May 2020. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website https://iacc.hhs.gov/publications/summary-of-advances/2019/.

Appendices

 
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